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Topic Review
X-linked Cardiac Valvular Dysplasia
X-linked cardiac valvular dysplasia is a condition characterized by the abnormal development (dysplasia) of heart (cardiac) valves. The normal heart has four valves, two on the left side of the heart and two on the right side, that allow blood to move through the heart and prevent blood from flowing backward. In X-linked cardiac valvular dysplasia, one or more of the four heart valves is thickened and cannot open and close completely when the heart beats and pumps blood. These malformed valves can cause abnormal blood flow and an irregular heart sound during a heartbeat (heart murmur).  
  • 531
  • 24 Dec 2020
Topic Review
X-linked Agammaglobulinemia
X-linked agammaglobulinemia (XLA) is a condition that affects the immune system and occurs almost exclusively in males.
  • 522
  • 24 Dec 2020
Topic Review
X-linked Adrenoleukodystrophy
X-linked adrenoleukodystrophy is a genetic disorder that occurs primarily in males. It mainly affects the nervous system and the adrenal glands, which are small glands located on top of each kidney. In this disorder, the fatty covering (myelin) that insulates nerves in the brain and spinal cord is prone to deterioration (demyelination), which reduces the ability of the nerves to relay information to the brain. In addition, damage to the outer layer of the adrenal glands (adrenal cortex) causes a shortage of certain hormones (adrenocortical insufficiency). Adrenocortical insufficiency may cause weakness, weight loss, skin changes, vomiting, and coma.  
  • 532
  • 24 Dec 2020
Topic Review
X-linked adrenal Hypoplasia Congenita
X-linked adrenal hypoplasia congenita is a disorder that mainly affects males. It involves many hormone-producing (endocrine) tissues in the body, particularly a pair of small glands on top of each kidney called the adrenal glands. These glands produce a variety of hormones that regulate many essential functions in the body.
  • 562
  • 24 Dec 2020
Topic Review
X-linked Acrogigantism
X-linked acrogigantism (X-LAG) is a condition that causes abnormally fast growth beginning early in life. Babies with this condition are a normal size at birth but begin to grow rapidly in infancy or early childhood, and affected children are taller than their peers.  
  • 550
  • 24 Dec 2020
Topic Review
X Display Manager (Program Type)
In the X Window System, an X display manager is a graphical login manager which starts a session on an X server from the same or another computer. A display manager presents the user with a login screen. A session starts when a user successfully enters a valid combination of username and password. When the display manager runs on the user's computer, it starts the X server before presenting the user the login screen, optionally repeating when the user logs out. In this condition, the DM realizes in the X Window System the functionality of getty and login on character-mode terminals. When the display manager runs on a remote computer, it acts like a telnet server, requesting username and password and starting a remote session. X11 Release 3 introduced display managers in October 1988 with the aim of supporting the standalone X terminals, just coming onto the market. Various display managers continue in routine use to provide a graphical login prompt on standalone computer workstations running X. X11R4 introduced the X Display Manager Control Protocol (XDMCP) in December 1989 to fix problems in the X11R3 implementation.
  • 549
  • 29 Sep 2022
Topic Review
X Chromosome
The X chromosome is one of the two sex chromosomes in humans (the other is the Y chromosome). The sex chromosomes form one of the 23 pairs of human chromosomes in each cell.
  • 1.1K
  • 24 Dec 2020
Topic Review
X 2000
X 2000, also called SJ X2 or simply as X2, is a tilting train operated by SJ in Sweden. It was constructed by Kalmar Verkstad in Kalmar, Sweden (prior to the company being bought by Adtranz in 1996) and launched in 1990 as a first-class only train with a meal included in the ticket price, and free use of the train's fax machine. There is a bistro on board that serves snack bar-style dishes. From 1995 second class was introduced. All trains are equipped with Wi-Fi for passenger access to the Internet and were repainted grey as of 2005. The trains also have electric power supply sockets at all seats in both first and second class. The trains have been fitted with repeaters to improve mobile phone reception. It has a top commercial speed of 200 km/h (120 mph), but has reached 276 km/h (171 mph) in a test. The reason the X2 was chosen was that Sweden (like most other countries) has very curved railways, and not enough traffic to justify building special high-speed railway lines (at least before 1990). As a result, a Swedish tilting train had to be developed. A tilting train provided the advantages of high speed and comfort for the passengers, as tilting trains can run through sharp (short radius or tight) curves up to 15% faster than non-tilting trains. The X2 was designed and built by ASEA (later ABB Asea Brown Boveri, Adtranz ABB Daimler Benz Transportation and now Bombardier Transportation). SJ ordered 20 trainsets in August 1986 and planned to order further 30 trainsets. However, this figure was later reduced to only 43 trainsets.
  • 853
  • 29 Sep 2022
Topic Review
WWOX Impairment in Neurological Disorders
There is an emerging role of the transcriptional regulator WW domain containing oxidoreductase (WWOX) in a number of neurological disorders including early-onset epilepsy, autism spectrum disorder (ASD), multiple sclerosis (MS), and Alzheimer’s disease. However, the underlying mechanism of WWOX function is still currently unknown.  
  • 557
  • 21 Apr 2021
Topic Review
WWOX Controls Cell Survival, Immune Response, Disease Progression
Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer’s disease (AD) progression. Supporting evidence shows that the more strongly WWOX binds intracellular protein partners, the weaker is cancer cell growth in vivo. Whether this correlates with retardation of AD progression is unknown. Two functional forms of WWOX exhibit opposite functions. pY33-WWOX is proapoptotic and anticancer, and is essential for maintaining normal physiology. 
  • 574
  • 14 Jul 2022
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