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Topic Review
1-C Metabolism in AML
One-carbon (1-C) metabolism is essential for numerous cancer cell functions, including protein and nucleic acid synthesis and maintaining cellular redox balance, and inhibition of the 1-C pathway has yielded several highly active drugs, such as methotrexate and 5-FU. 
  • 671
  • 07 Jul 2021
Topic Review
1,2,4-Triazoles
Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity.
  • 1.8K
  • 23 Aug 2021
Topic Review
1,3-Butadiene
1,3-Butadiene is the organic compound with the formula (CH2=CH)2. It is a colorless gas that is easily condensed to a liquid. It is important industrially as a monomer in the production of synthetic rubber. The molecule can be viewed as the union of two vinyl groups. It is the simplest conjugated diene. Although butadiene breaks down quickly in the atmosphere, it is nevertheless found in ambient air in urban and suburban areas as a consequence of its constant emission from motor vehicles. The name butadiene can also refer to the isomer, 1,2-butadiene, which is a cumulated diene with structure H2C=C=CH−CH3. This allene has no industrial significance.
  • 1.0K
  • 17 Oct 2022
Topic Review
1,3,4-oxadiazol-2-one derivatives as FAAH Inhibitors
The fatty acid amide hydrolase enzyme (FAAH) belongs to the serine hydrolase superfamily. It is involved in the degradation of biologically active lipids. Enzyme inhibitors may exhibit analgesic, anti-inflammatory, anxiolytic, and antidepressant activity. Importantly, blockade of FAAH does not cause undesirable side effects of direct cannabinoid agonists. Due to that fact, its blockade became an emerging strategy in the treatment of several central nervous system (CNS) and peripheral diseases. The development of novel effective FAAH inhibitors became a key focus in drug design. 
  • 535
  • 24 Sep 2021
Topic Review
1,3,4-Oxadiazole
Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity.
  • 1.4K
  • 13 Sep 2021
Topic Review
100,000-Year Problem
The 100,000-year problem ("100 ky problem", "100 ka problem") of the Milankovitch theory of orbital forcing refers to a discrepancy between the reconstructed geologic temperature record and the reconstructed amount of incoming solar radiation, or insolation over the past 800,000 years. Due to variations in the Earth's orbit, the amount of insolation varies with periods of around 21,000, 40,000, 100,000, and 400,000 years. Variations in the amount of incident solar energy drive changes in the climate of the Earth, and are recognised as a key factor in the timing of initiation and termination of glaciations. While there is a Milankovitch cycle in the range of 100,000 years, related to Earth's orbital eccentricity, its contribution to variation in insolation is much smaller than those of precession and obliquity. The 100,000-year-problem refers to the lack of an obvious explanation for the periodicity of ice ages at roughly 100,000 years for the past million years, but not before, when the dominant periodicity corresponded to 41,000 years. The unexplained transition between the two periodicity regimes is known as the Mid-Pleistocene Transition, dated to some 800,000 years ago. The related "400,000-year-problem" refers to the absence of a 400,000-year periodicity due to orbital eccentricity in the geological temperature record over the past 1.2 million years. The transition in periodicity from 41,000 years to 100,000 years can now be reproduced in numerical simulations that include a decreasing trend in carbon dioxide and glacially induced removal of regolith, as explained in more detail in the article Mid-Pleistocene Transition.
  • 908
  • 08 Oct 2022
Topic Review
100% Renewable Electricity in Indonesia
Researchers investigate an Indonesian energy decarbonization pathway using mostly solar photovoltaics. An hourly energy balance analysis using ten years of meteorological data was performed for a hypothetical solar-dominated Indonesian electricity system for the consumption of 3, 6 and 10 megawatt-hours (MWh) per capita per year (compared with current consumption of 1 MWh per capita per year). This research showed that Indonesia’s vast solar potential combined with its vast capacity for off-river pumped hydro energy storage could readily achieve 100% renewable electricity at low cost. The levelized cost of electricity (LCOE) for a balanced solar-dominated system in Indonesia was found to be in the range of 77–102 USD/MWh.
  • 408
  • 29 Jan 2024
Topic Review
100% Renewable Energy: Concepts and Progresses
Some advanced countries’ rapid population, economic growth, and energy consumption expansion contribute significantly to global CO2 emissions. And while developed countries have achieved 100% universal access to electricity, mainly from non-renewable sources, many developing countries still lack it. This presents challenges and opportunities for achieving the United Nations’ Sustainable Development Goals (SDGs) 7 and 13 of generating all energy from cleaner or low-carbon sources to reduce CO2 emissions in all countries and combating climate change consequences. Renewable energies have been widely acknowledged to greatly advance this endeavour, resulting in many studies and about 30 countries already with over 70% of their national electricity mix from RE. It has birthed a new paradigm and an emerging field of 100% RE for all purposes, receiving much attention from academia and in public discourse. 
  • 625
  • 20 Sep 2023
Topic Review
105×617mm
The 105×617mm (4.1 inch) also known as 105 × 617 R is a common, NATO-standard, tank gun cartridge used in 105mm guns such as those derived from the Royal Ordnance L7. The 105 × 617 R cartridge was originally developed from the 84 mm (3.3 in) calibre Ordnance QF 20-pounder 84 × 618R cartridge as part of the development of the L7 105 mm rifled gun.
  • 1.7K
  • 03 Nov 2022
Topic Review
10q26 Deletion Syndrome
10q26 deletion syndrome is a condition that results from the loss (deletion) of a small piece of chromosome 10 in each cell. The deletion occurs on the long (q) arm of the chromosome at a position designated 10q26.
  • 2.4K
  • 26 Aug 2021
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