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Topic Review
Updated Understanding of Cancer
       Cancer is a tumorigenesis process that forms a mass of cells that we call a tumor. During tumorigenesis, the cells that compose the tumor can be benign or malignant. When the cells in the tumor are normal but old, the tumor is termed benign. When the cells in the tumor are abnormal and can grow uncontrollably, the tumor is malignant. Sometimes a benign tumor can transform into a malign one if the normal old cells begin to develop abnormalities, such as DNA mutations, and grow rapidly. - by Cristian Muresanu
  • 1.3K
  • 30 Oct 2020
Topic Review
Updated Principles of Sustainable Engineering
Sustainable engineering refers to the integration of social, environmental, and economic considerations into product, process, and energy system design methods. Additionally, sustainable engineering encourages the consideration of the complete product and process lifecycle during the design effort. 
  • 8.4K
  • 24 Jun 2022
Topic Review
Update on Domestic Violence and Traumatic Brain Injury
Traumatic brain injury (TBI), which is the leading cause of all deaths for Americans less than 44 years old, is defined as “an alteration in brain function, or other evidence of brain pathology, caused by an external force that may result in cognitive impairment". Intimate partner violence (IPV) is a type of domestic violence that is defined as “behaviors that are intended to exert power and control over another individual, including physical, sexual, verbal, emotional, and financial abuse, and/or stalking".
  • 725
  • 21 Feb 2022
Topic Review
Update on Cyber Health Psychology
In recent years, there has been more and more talk of cyber health psychology and the implication that new technologies can have in the diagnosis, treatment, and rehabilitation of psychopathological issues in the field of mental health, ranging from post-traumatic stress disorder (PTSD) to addiction to substances of abuse.
  • 645
  • 25 Mar 2022
Topic Review
Update on Cellular Models of Striated Muscle Laminopathies
The lamin A/C gene (LMNA) codes for nuclear intermediate filaments constitutive of the nuclear lamina. LMNA has 12 exons and alternative splicing of exon 10 results in two major isoforms of the A-type lamins - lamins A and C. Mutations found throughout LMNA cause a group of diseases collectively known as laminopathies, of which the type, diversity, penetrance, and severity of phenotypes can vary from one individual to the other, even between individuals carrying the same mutation. The majority of laminopathies affect the cardiac and/or skeletal muscles. The underlying molecular mechanisms contributing to such tissue-specific phenotypes caused by mutations in a ubiquitously expressed gene are not yet well elucidated.
  • 493
  • 21 Feb 2023
Topic Review
Upcycling of Brewers' Spent Grains
Brewers' spent grains (BSGs) are the most important by-product of the brewing industry and are rich in protein and fiber. However, abundant amounts of BSGs are discarded annually worldwide. This project aimed to employ and compare innovative drying techniques to introduce snacks with protein sources derived from leftover BSGs. This study explored the dehydration kinetics of BSGs and the effect of three different drying methods—oven drying (OD), freeze drying (FD), and vacuum microwave drying (VMD)—on their protein content and functionality. Then, an energy and exergy analysis for the drying methods was given. Accordingly, a snack product (baked chips) using the dehydrated BSGs was developed by a sensory panel study to assess consumer acceptability of the final products. It was found that the VMD process took less drying time (48 min) compared to OD (50 min), with higher effectiveness as a drying process. VMD-treated BSG also showed moderate protein functionality and the highest overall acceptability when used in baked chips. Thus, VMD might be used as a sustainable drying technology for thermal treatment and valorization of BSG. In addition to having implications for dietary health, findings can help improve the economy of the breweries and other industries that deal with the processing of grains by valorizing their process waste and contributing to sustainability.
  • 1.1K
  • 28 Oct 2020
Topic Review
Upāsaka and Upāsikā
Upāsaka (masculine) or Upāsikā (feminine) are from the Sanskrit and Pāli words for "attendant". This is the title of followers of Buddhism (or, historically, of Gautama Buddha) who are not monks, nuns, or novice monastics in a Buddhist order, and who undertake certain vows. In modern times they have a connotation of dedicated piety that is best suggested by terms such as "lay devotee" or "devout lay follower".
  • 2.2K
  • 23 Nov 2022
Topic Review
Up-Frameshift Protein 1 in Human Disorders
Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism. It is well known as one of the key elements involved in mRNA decay pathways and participates in transcript and protein quality control in several different aspects. Firstly, UPF1 specifically degrades premature termination codon (PTC)-containing products in a nonsense-mediated mRNA decay (NMD)-coupled manner. Additionally, UPF1 can potentially act as an E3 ligase and degrade target proteins independently from mRNA decay pathways. Thus, UPF1 protects cells against the accumulation of misfolded polypeptides. However, this multitasking protein may still hide many of its functions and abilities.
  • 379
  • 18 May 2023
Topic Review
Up-Flow Anaerobic Sludge Blanket
The interest in research on up-flow anaerobic sludge blanket (UASB) reactors is growing. Although the state of research on UASB is to be considered advanced, there are still several points that will be developed in future research such as the consolidation of the results obtained on a semi-industrial or real scale, the use of real matrices instead of synthetic ones.
  • 924
  • 21 Oct 2021
Topic Review
Up Series
Lua error in package.lua at line 80: module 'Module:Television infoboxes disambiguation check' not found. The Up Series is a series of documentary films produced by Granada Television for ITV that have followed the lives of fourteen British children since 1964, when they were seven years old. So far the documentary has had eight episodes spanning 49 years (one episode every seven years) all of which were broadcast on ITV, apart from the 6th episode which was broadcast on BBC One. In a 2005 Channel 4 programme, the series topped the list of The 50 Greatest Documentaries. The children were selected to represent the range of socio-economic backgrounds in Britain at that time, with the explicit assumption that each child's social class predetermines their future. Every seven years, the director, Michael Apted, films material from those of the fourteen who choose to participate. The last installment, 56 Up, premiered in May 2012; Apted has stated that filming for 63 Up will occur in late 2018, for release in spring 2019. Apted has also been reported as saying: "I hope to do 84 Up when I'll be 99." The aim of the series is stated at the beginning of 7 Up as: "Why do we bring these children together? Because we want to get a glimpse of England in the year 2000. The shop steward and the executive of the year 2000 are now seven years old."
  • 1.4K
  • 14 Oct 2022
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