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Topic Review
Vitamin A Transporters in Visual Function
Vitamins are essential compounds obtained through diet that are necessary for normal development and function in an organism. One of the most important vitamins for human physiology is vitamin A, a group of retinoid compounds and carotenoids, which generally function as a mediator for cell growth, differentiation, immunity, and embryonic development, as well as serving as a key component in the phototransduction cycle in the vertebrate retina. 
  • 529
  • 25 Nov 2021
Topic Review
Vitamin A in Retinal Diseases
Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is essential for several physiological processes. Either hyper- or hypovitaminosis can be harmful. One of the most important vitamin A functions is its involvement in visual phototransduction, where it serves as the crucial part of photopigment, the first molecule in the process of transforming photons of light into electrical signals. In this process, large quantities of vitamin A in the form of 11-cis-retinal are being isomerized to all-trans-retinal and then quickly recycled back to 11-cis-retinal. Complex machinery of transporters and enzymes is involved in this process (i.e., the visual cycle). Any fault in the machinery may not only reduce the efficiency of visual detection but also cause the accumulation of toxic chemicals in the retina. 
  • 1.5K
  • 10 Feb 2022
Topic Review
Vitamin A Deficiency and Poultry Health
Vitamin A, a critical micronutrient, plays a vital role in maintaining poultry health and maximizing productivity. Vitamin A deficiency can have severe consequences on poultry health, compromising growth, reproduction, immune competence, and overall productivity.
  • 306
  • 04 Dec 2023
Topic Review
Vitamin A and Pregnancy
Vitamin A is a crucial micronutrient for pregnant women and their fetuses. In addition to being essential for morphological and functional development and for ocular integrity, vitamin A exerts systemic effects on several fetal organs and on the fetal skeleton. 
  • 898
  • 09 Aug 2022
Topic Review
Vitamin A and Bladder Cancer
Bladder cancer (BC) is the tenth most common cancer worldwide with a high recurrence rate, morbidity and mortality. Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC risk. In addition, retinoids, natural and synthetic derivatives of vitamin A, are intensively studied in cancer research due to their antioxidant properties and their ability to regulate cell growth, differentiation, and apoptosis. Findings from in vivo and in vitro models of BC show great potential for the use of retinoids in the chemoprevention and treatment of BC. However, translation to the clinical practice is limited.
  • 491
  • 25 Apr 2021
Biography
Vitaly Alexandrovich Khonik
Khonik Vitaly Alexandrovich (Russian: Хоник Виталий Александрович; born 17 December 1955) is a Russian physicist, doctor of physics and mathematics, professor, head of a laboratory researching the physics of non-crystalline materials, and head of the Department of General Physics at Voronezh State Pedagogical University (VSPU). He was born in Kemerovo, USSR. [1] His lab
  • 391
  • 15 Nov 2022
Topic Review
Vital Echocardiographic Data Prior to Ventricular Arrhythmia Ablation
Ventricular arrhythmias (VA) are a major cause of sudden cardiac death (SCD). Echocardiography is the first widely available imaging tool which guides VA management strategies. Along with other invasive and noninvasive imaging techniques, it provides essential information for identification of VA substrate such as differentiation between ischemic and non-ischemic etiology and identification of structural heart disease. Both classic as well as novel echocardiographic techniques such as left ventricular strain measurement and mechanical dispersion assessment provide prognostic information and assist in risk stratification. Furthermore, intracardiac echocardiography may have an adjunctive role for the VA ablation by providing real-time visualization of cardiac structures, continuous monitoring of catheter location and early recognition of procedural complications.
  • 346
  • 21 Oct 2022
Topic Review
Visually Impaired Persons’ Assistance
The development of new solutions to assist blind people is a major research domain having great potential to enhance the daily lives of such people. These innovative solutions aim to augment the perception of the surrounding environment for the blind and severely visually impaired. 
  • 245
  • 06 Dec 2023
Topic Review
Visually Impaired People
Blind and Visually impaired people (BVIP) face a range of practical difficulties when undertaking outdoor journeys as pedestrians. Over the past decade, a variety of assistive devices have been researched and developed to help BVIP navigate more safely and independently. In addition, research in overlapping domains are addressing the problem of automatic environment interpretation using computer vision and machine learning, particularly deep learning, approaches. Our aim in this article is to present a comprehensive review of research directly in, or relevant to, assistive outdoor navigation for BVIP. We breakdown the navigation area into a series of navigation phases and tasks. We then use this structure for our systematic review of research, analysing articles, methods, datasets and current limitations by task. We also provide an overview of commercial and non-commercial navigation applications targeted at BVIP. Our review contributes to the body of knowledge by providing a comprehensive, structured analysis of work in the domain, including the state of the art, and guidance on future directions. It will support both researchers and other stakeholders in the domain to establish an informed view of research progress. 
  • 682
  • 17 May 2021
Topic Review
Visualizing Collagen Tissue Microarchitecture Using Contrast-Enhanced MicroCT
Micro-computed tomography (microCT) is a common tool for the visualization of the internal composition of organic tissues. Collagen comprises approximately 25–35% of the whole-body protein content in mammals, and the structure and arrangement of collagen fibers contribute significantly to the integrity of tissues. Collagen type I is also frequently used as a key structural component in tissue-engineered and bioprinted tissues. However, the imaging of collagenous tissues is limited by their inherently low X-ray attenuation, which makes them indistinguishable from most other soft tissues. An imaging contrast agent that selectively alters X-ray attenuation is thus essential to properly visualize collagenous tissue using a standard X-ray tube microCT scanner.  The entry provides basic understanding of the physical and chemical aspects of contrast agents that are specific for collagen and some of the key biological factors in selecting these agents for microCT.
  • 85
  • 18 Jul 2024
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