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Topic Review
Voltage-Source-Converter-Based High Voltage Direct Current Transmission System
Long-distance offshore wind power transmission systems utilize multi-terminal high voltage direct current (MT-HVDC) connections based on voltage source converters (VSCs). In addition to having the potential to work around restrictions, the VSC-based MT-HVDC transmission system has significant technical and economic merits over the HVAC transmission system. Offshore wind farms (OWFs) will inevitably grow because of their outstanding resistance to climate change and ability to provide sustainable energy without producing hazardous waste. Due to stronger and more persistent sea winds, the OWF often has a higher generation capacity with less negative climate effects. The majority of modern installations are distant from the shore and produce more power than the early OWF sites, which are situated close to the shore. 
  • 371
  • 20 Nov 2023
Topic Review
Voltage-Gated Sodium Channel in Neurodegenerative Diseases
The pore-forming subunits (α subunits) of voltage-gated sodium channels (VGSC) are encoded in humans by a family of nine highly conserved genes. Among them, SCN1A, SCN2A, SCN3A, and SCN8A are primarily expressed in the central nervous system. The encoded proteins Nav1.1, Nav1.2, Nav1.3, and Nav1.6, respectively, are important players in the initiation and propagation of action potentials and in turn of the neural network activity. In the context of neurological diseases, mutations in the genes encoding Nav1.1, 1.2, 1.3 and 1.6 are responsible for many forms of genetic epilepsy and for Nav1.1 also of hemiplegic migraine. Conversely, VGSCs seem to have a modulatory role in the most common neurodegenerative diseases such as Alzheimer’s, where SCN8A expression has been shown to be negatively correlated with disease severity.
  • 451
  • 30 May 2023
Topic Review
Voltage-Gated K+ Channels
Voltage-gated K+ (Kv) channels are intrinsic plasma membrane proteins mediating the selective flow of potassium ions in response to depolarization of the transmembrane electric field. Their ionic selectivity and voltage dependence allow Kv channels to be central players in virtually all physiological functions, including the maintenance and modulation of neuronal and muscular (both cardiac and skeletal) excitability, regulation of calcium signaling cascades, control of cell volume, immune response, hormonal secretion, and others.
  • 1.0K
  • 29 Jan 2022
Topic Review
Voltage-Gated Calcium Channels for the Treatment of Pain
The voltage-gated calcium channels (VGCCs) are classified in low- (T-type or Cav3) or high-voltage activation (L or Cav1, N, P/Q, and R-type or Cav2). They can be further subclassified by structural similarities (channel-forming α1-subunit) where L-(Cav1.1, Cav1.2, Cav1.3, and Cav1.4), P/Q-(Cav2.1), N-(Cav2.2), and R-(Cav2.3) channels form heteromultimers (along with auxiliary β-, α2δ, and γ-subunits) and T-type (Cav3.1, Cav3.2, and Cav3.3) channels, which are α1-subunit monomers. Pain perception is a sensory and emotionally unpleasant experience; moreover, it represents a huge personal, medical, and economic burden that pharmacotherapy targeting brain pathways is now being researched for and developed in the medical field. Obviously, acute pain does not carry the load of chronic pain that is conceived as a disease on its own and as secondary to an underlying disease (like a symptom). Chronic pain is related to neuronal adaptations and is high risk for psychological distress and sleep deprivation, among other consequences impairing the quality of life. 
  • 400
  • 08 Jun 2023
Topic Review
Voltage-Dependent Anion Selective Channel
VDAC (voltage-dependent anion selective channel) proteins, also known as mitochondrial porins, are the most abundant proteins of the outer mitochondrial membrane (OMM) where they play a vital role in various cellular processes, in the regulation of metabolism, and in survival pathways.
  • 576
  • 19 Apr 2022
Topic Review
Voltage Lifting Techniques for Non-Isolated DC/DC Converters
The conventional boost DC/DC converter is used to step up the input voltage to a desired higher level within the practical limit required by the load with very few components. Stepping up the voltage is achieved by storing the energy in the inductor and releasing it to the output at a higher voltage. The boost converter is very popular for capacitive load applications such as photo-flashers and battery chargers. It is also used in automotive applications, power amplifiers, adaptive control applications, battery power systems, consumer electronics, DC motor drives and power factor correction circuits.
  • 1.5K
  • 02 Mar 2023
Topic Review
Voltage Gated Ion Channels
Safety Pharmacology is one of the most dynamically developing disciplines, whose objective is to assess the potential risks of improperly conducted pharmacotherapy. Evaluation of a potential risks in the use of a given substance is vital for placing a new medicine on the market. The Organisation for Economic Co-operation and Development (OECD) has issued a number of guidelines for drug safety testing [1, 2]. However, the continuous development of medicine demands the extension and refinement of the test panel that a new molecule must undergo before it can be released for use by patients. Toxic effects of compounds on the most important organs are among the most frequent reasons of elimination of substances from further tests. Additionally, safety tests are also performed for medicines already approved for use. Such trials are required, e.g., to register new indications for "old" drugs.  The above mentioned activities require a suitable identifications of the antitargets which are commonly defined as undesirable molecular targets that play an essential role in the proper functioning of cells. Down modulation of an antitarget results in clinically unacceptable side effects, initiation of disease, or deleterious alterations in disease progression. This results in shorter onset time of the disease, increased disease burden, poorer patient outcome, or decreased survival time.
  • 752
  • 27 Jan 2021
Topic Review
Volkswagen Passat NMS
The 2012 Volkswagen Passat (internally designated Volkswagen New Midsize Sedan, or NMS while under development) is a mid-sized sedan that debuted in January 2011 at the Detroit Auto Show, is manufactured at the Volkswagen Chattanooga Assembly Plant, replaces the Passat B6 in the North American market, and is marketed also in South Korea. At its introduction, the Passat NMS was part of Volkswagen Group's strategy to sell over 800,000 vehicles per year in the North American market. The vehicle was developed by Shanghai Volkswagen Automotive and Volkswagen Passenger Cars, and is partially based on the PQ46 platform used by the European Passat.
  • 2.3K
  • 18 Oct 2022
Topic Review
Volkswagen Golf Estate
Volkswagen has marketed estate/station wagon variants of its Golf model since its third generation in 1993, through its current seventh generation. Volkswagen marketed the station wagon as Jetta Sportwagen and later the Golf Sportwagen in the United States, the Bora Sportwagen in Mexico, Golf Break and later Golf SW in France, Jetta Variant in Brazil, Vento Variant in Argentina, Jetta Wagon in Canada (only for 2009), Golf Wagon in Canada (onwards from 2010), Golf Estate in the United Kingdom and prominently as the Golf Variant in the domestic market in Germany and most other markets.
  • 970
  • 30 Oct 2022
Topic Review
Volcanology of Venus
The surface of Venus is dominated by volcanic features and has more volcanoes than any other planet in the Solar System. It has a surface that is 90% basalt, and about 65% of the planet consists of a mosaic of volcanic lava plains, indicating that volcanism played a major role in shaping its surface. There are more than 1,000 volcanic structures and possible periodic resurfacing of Venus by floods of lava. The planet may have had a major global resurfacing event about 500 million years ago, from what scientists can tell from the density of impact craters on the surface. Venus has an atmosphere rich in carbon dioxide, with a density that is 90 times greater than Earth's atmosphere. Even though there are over 1,600 major volcanoes on Venus, none are known to be erupting at present and most are probably long extinct. However, radar sounding by the Magellan probe revealed evidence for comparatively recent volcanic activity at Venus's highest volcano Maat Mons, in the form of ash flows near the summit and on the northern flank. Although many lines of evidence suggest that Venus is likely to be volcanically active, present-day eruptions at Maat Mons have not been confirmed. Nevertheless, other more recent studies, in January 2020, suggests Venus is currently volcanically active.
  • 1.3K
  • 22 Nov 2022
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