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Topic Review
Clostridioides difficile Mouse Model
Clostridioides difficile is an anaerobic, spore-forming bacterium associated with intestinal infection, manifesting a broad spectrum of gastrointestinal symptoms, ranging from mild diarrhea to severe colitis. A primary risk factor for the development of C. difficile infection (CDI) is antibiotic exposure. Elderly and immunocompromised individuals are particularly vulnerable to CDI. A pivotal aspect for comprehending the complexities of this infection relies on the utilization of experimental models that mimic human CDI transmission, pathogenesis, and progression. These models offer invaluable insights into host–pathogen interactions and disease dynamics, and serve as essential tools for testing potential therapeutic approaches.
  • 237
  • 23 Feb 2024
Topic Review
Cochliobolus, Bipolaris, and Curvularia Species
Cochliobolus, Bipolaris, and Curvularia genera contain various devastating plant pathogens that cause severe crop losses worldwide. The species belonging to these genera also perform a variety of diverse functions, including the remediation of environmental contaminations, beneficial phytohormone production, and maintaining their lifestyle as epiphytes, endophytes, and saprophytes. Research has revealed that despite their pathogenic nature, these fungi also play an intriguing role in agriculture. They act as phosphate solubilizers and produce phytohormones, such as indole acetic acid (IAA) and gibberellic acid (GAs), to accelerate the growth of various plants. Some species have also been reported to play a significant role in plant growth promotion during abiotic stresses, such as salinity stress, drought stress, heat stress, and heavy metal stress, as well as act as a biocontrol agent and a potential mycoherbicide. Similarly, these species have been reported in numerous industrial applications to produce different types of secondary metabolites and biotechnological products and possess a variety of biological properties, such as antibacterial, antileishmanial, cytotoxic, phytotoxic, and antioxidant activities.
  • 478
  • 06 Mar 2023
Topic Review
Coxiella burnetii Infection in Cats
Coxiella burnetii is the etiologic agent of the zoonosis called Q fever. The disease was first described in Australia in 1935 by Edward Holbrook Derrick who investigated a disease in a group of abattoir workers in Brisbane, Queensland, Australia. The “Q” comes from “query” fever, as named by Derrick.
  • 163
  • 12 Dec 2023
Topic Review
Crossiella in Caves
The genus Crossiella contains two species, C. equi, causing nocardioform placentitis in horses, and C. cryophila, an environmental bacterium.
  • 578
  • 19 Jun 2023
Topic Review
Cryptococcus neoformans/C. gattii Complex
The epidemiology of the Cryptococcus species complex (SC) is well known and briefly summarized below. Among these species, most clinical isolates are C. neoformans; C. gattii has been isolated in the U.S., mostly in the Pacific Northwest area.
  • 313
  • 29 May 2023
Topic Review
Cutibacterium acnes Dysbiosis
This research presents the virulence factors, clinical relevance, and current treatments of C. acnes, highlighting its association with AV, post-surgical infections, and other diseases. It also explores alternative innovative therapies such as phage therapy in development/research that are gaining prominence, with a growing focus on personalized medical approaches.
  • 242
  • 17 Nov 2023
Topic Review
Dactylospongia elegans as A Promising Drug Source
Dactylospongia elegans Thiele (Thorectidae) is a wealth pool of various classes of sesquiterpenes, including hydroquinones, quinones, and tetronic acid derivatives. These metabolites possessed a wide array of potent bioactivities such as antitumor, cytotoxicity, antibacterial, and anti-inflammatory. 
  • 501
  • 31 Mar 2022
Topic Review
Datura Species
Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes necessary to be aware of the toxic aspects and the potential risks accompanying its use.
  • 1.7K
  • 25 Apr 2022
Topic Review
Dehydrogenases involved in Reduction of CO2 to CH3OH
The three dehydrogenase enzymes involved in the CO2 to methanol conversion are: Formate dehydrogenase, Formaldehyde dehydrogenase and Alcohol dehydrogenase.
  • 623
  • 26 Aug 2022
Topic Review
Democracy and the Common Wealth
Democracy and the Common Wealth: Breaking the Stranglehold of the Special Interests is a 2010 book by urban designer, policy analyst and artist Michael E. Arth. Arth attempts to expose what he calls the "dirty secrets" of America's electoral system, and provides a list of solutions that he believes will result in a "truly representative democracy." This democracy would be led by effective, trustworthy leaders, who would be elected by a majority, and who would not have to spend their time raising campaign funds, or catering to paid lobbyists. It also tells the story of the first year of Florida's 2010 gubernatorial race, from his point of view as an outsider, lacking in personal wealth or party backing. In the main text, and in the postscript, Arth writes about how he became an independent candidate for governor after being "frozen out" of the "undemocratic" Florida Democratic Party for not having millions of dollars, and for suggesting that campaigns be about issues instead of money. The first edition of the book has 480 pages including 72 illustrations and charts and was first published in both e-book and print in May 2010. The e-book version also includes a postscript about the BP Oil Spill and energy policy, and a section on Arth’s switch to No Party Affiliation.
  • 328
  • 22 Nov 2022
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