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Topic Review
Applications of Heterocyclic Compounds
Fluorescently labelled heterocyclic compounds are useful in bioanalytical applications, including in vivo imaging, high throughput screening, diagnostics, and light-emitting diodes. These compounds have various therapeutic properties, including antifungal, antitumor, antimalarial, anti-inflammatory, and analgesic activities. Different neutral fluorescent markers containing nitrogen heterocycles (quinolones, azafluoranthenes, pyrazoloquinolines, etc.) have several electrochemical, biological, and nonlinear optic applications. Photodynamic therapy (PDT), which destroys tumors and keeps normal tissues safe, works in the presence of molecular oxygen with light and a photosensitizing drugs (dye) to obtain a therapeutic effect. 
  • 5.7K
  • 18 Oct 2022
Topic Review
Queer Theory
Queer theory is a field of critical theory that emerged in the early 1990s out of the fields of queer studies and women's studies. Queer theory includes both queer readings of texts and the theorization of 'queerness' itself. Heavily influenced by the work of Lauren Berlant, Leo Bersani, Judith Butler, Lee Edelman, Jack Halberstam, and Eve Kosofsky Sedgwick, queer theory builds both upon feminist challenges to the idea that gender is part of the essential self and upon gay/lesbian studies' close examination of the socially constructed nature of sexual acts and identities. Whereas gay/lesbian studies focused its inquiries into natural and unnatural behavior with respect to homosexual behavior, queer theory expands its focus to encompass any kind of sexual activity or identity that falls into normative and deviant categories. Italian feminist and film theorist Teresa de Lauretis coined the term "queer theory" for a conference she organized at the University of California, Santa Cruz in 1990 and a special issue of Differences: A Journal of Feminist Cultural Studies she edited based on that conference. Through the context of heterosexuality being the origin and foundation of society’s heteronormative stability, the concept of queerness focuses on, “mismatches between sex, gender and desire” Queerness has been associated most prominently with bisexual, lesbian and gay subjects, but its analytic framework also includes such topics as cross-dressing, intersex bodies and identities, gender ambiguity and gender-corrective surgery. Queer theory holds that individual sexuality is a fluid, fragmented, and dynamic collectivity of possible sexualities and it may vary at different points of his life. Its attempted debunking of stable (and correlated) sexes, genders, and sexualities develops out of the specifically lesbian and gay reworking of the post-structuralist figuring of identity as a constellation of multiple and unstable positions. Queer theory also examines the discourses of homosexuality developed in the last century in order to place the "queer" into historical context, deconstructing contemporary arguments both for and against this latest terminology.
  • 5.7K
  • 17 Oct 2022
Topic Review
Agorism
Agorism is a libertarian social philosophy that advocates creating a society in which all relations between people are voluntary exchanges by means of counter-economics, thus engaging with aspects of peaceful revolution. It was first proposed by libertarian philosopher Samuel Edward Konkin III at two conferences, CounterCon I in October 1974 and CounterCon II in May 1975, both conferences organized by J. Neil Schulman.
  • 5.7K
  • 23 Nov 2022
Topic Review
Atomic Units
Atomic units (au or a.u.) form a system of natural units which is especially convenient for atomic physics calculations. There are two different kinds of atomic units, Hartree atomic units and Rydberg atomic units, which differ in the choice of the unit of mass and charge. This article deals with Hartree atomic units, where the numerical values of the following four fundamental physical constants are all unity by definition: In Hartree units, the speed of light is approximately [math]\displaystyle{ 137 }[/math]. Atomic units are often abbreviated "a.u." or "au", not to be confused with the same abbreviation used also for astronomical units, arbitrary units, and absorbance units in different contexts.
  • 5.7K
  • 10 Nov 2022
Topic Review
2015–16 Stock Market Selloff
The 2015–16 stock market selloff, also known as The Great Fall of China, was the period of decline in the value of stock prices globally that occurred between June 2015 to June 2016. It included the 2015–16 Chinese stock market turbulence, in which the SSE Composite Index fell 43% in just over 2 months between June 2015 and August 2015, which culminated in the devaluation of the yuan. Investors sold shares globally as a result of slowing growth in the GDP of China, a fall in petroleum prices, the Greek debt default in June 2015, the effects of the end of quantitative easing in the United States in October 2014, a sharp rise in bond yields in early 2016, and finally, in June 2016, the 2016 United Kingdom European Union membership referendum, in which Brexit was voted upon. By July 2016, the Dow Jones Industrial Average (DJIA) recovered and achieved record highs. The FTSE 100 Index did not do so until later in 2016.
  • 5.7K
  • 29 Nov 2022
Topic Review
Chinese Polearms
The three most common types of Chinese polearms are the ge (戈), qiang (槍), and ji (戟). They are translated into English as dagger-axe, spear, and halberd. Dagger-axes were originally a short slashing weapon with a 0.9 to 1.8 m long shaft, but around the 4th century BC a spearhead was added to the blade, and it became a halberd. The spear is also sometimes called a mao (矛), which is sometimes used to designate polearms with a wavy snake-like spearhead. There was another polearm weapon known as the pi (鈹), translated into English as either sword-staff or long lance, that was used from ancient times until the Han dynasty. It was essentially a short sword attached to a stick. From the Warring States period onward, the length of Chinese polearms varied from around 2.8 m to 5.5 m, however there is no specific designation for a pike in the traditional Chinese lexicon. A very long spear is just called a long spear.
  • 5.7K
  • 13 Oct 2022
Topic Review
Preterism
Preterism, a Christian eschatological view, interprets some (partial preterism) or all (full preterism) prophecies of the Bible as events which have already happened. This school of thought interprets the Book of Daniel as referring to events that happened from the 7th century BC until the first century AD, while seeing the prophecies of the Book of Revelation as events that happened in the first century AD. Preterism holds that Ancient Israel finds its continuation or fulfillment in the Christian church at the destruction of Jerusalem in AD 70. The term preterism comes from the Latin praeter, which is a prefix denoting that something is "past" or "beyond". Adherents of preterism are known as preterists. Preterism teaches that either all (full preterism) or a majority (partial preterism) of the Olivet discourse had come to pass by AD 70. Historically, preterists and non-preterists have generally agreed that the Jesuit Luis de Alcasar (1554–1613) wrote the first systematic preterist exposition of prophecy Vestigatio arcani sensus in Apocalypsi (published in 1614) during the Counter-Reformation.
  • 5.7K
  • 11 Oct 2022
Topic Review
Melatonin Protects Mitochondria and Adenosine Triphosphate Production
Melatonin (N-acetyl-5-methoxytryptamine) is a ubiquitous, mitochondria-targeted molecule present in all tested eukarya and bacteria. In March 2022, the first discovery of the serotonin N-acetyltransferase (SNAT) gene—responsible for the penultimate formation of N-acetylserotonin (NAS) before its final conversion into melatonin — in archaea further consolidates the status of melatonin as a regulator of biomolecular condensates in all three domains of life in the cellular empire. RNA viruses including SARS-CoV-2 contain proteins with intrinsically disordered regions that undergo liquid-liquid phase separation (LLPS). Liquid-liquid phase separation (LLPS) of these proteins form membraneless condensates that act as “viral factories” to facilitate and enhance replication. Phase separation of the SARS-CoV-2 nucleocapsid (N) protein is associated with mitochondrial dysfunction and rewiring of energy production away from oxidative phosphorylation (OXPHOS) to favor aerobic glycolysis in cytoplasm. Increased adenosine triphosphate (ATP) in cytoplasm supports viral replication. Melatonin protects mitochondria from damage, maintains adequate levels to disassemble “viral factories”, and prevents suppression of host antiviral immune responses by inhibiting nucleocapsid phase separation via antioxidant-dependent and -independent means.
  • 5.6K
  • 05 Sep 2022
Topic Review
Visual-SLAM Algorithms
The visual-based simultaneous localization and mapping (SLAM) techniques use one or more cameras in the sensor system, receiving 2D images as the source of information. In general, the visual-based SLAM algorithms are divided into three main threads: initialization, tracking, and mapping.
  • 5.7K
  • 23 Mar 2022
Topic Review
Intercropping
Intercropping ensures multiple benefits like enhancement of yield, environmental security, production sustainability and greater ecosystem services. In intercropping, two or more crop species are grown concurrently such that they coexist for a significant part of the crop cycle and interact among themselves and with agro-ecosystems.
  • 5.6K
  • 09 Jan 2022
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