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Topic Review
Biography
Topic Review
Multi-Drug-Resistant Bacterial Infections
Antimicrobial resistance (AMR) remains one of the top public health issues of global concern. Among the most important strategies for AMR control there is the correct and appropriate use of antibiotics, including those available for the treatment of AMR pathogens.
442
15 Jun 2021
Topic Review
Multi-Omic Approaches to Breast Cancer
Breast cancer (BC) is the most frequently diagnosed tumor and the leading cause of cancer deaths in women worldwide.
458
24 Sep 2021
Topic Review
Multicomponent Mixtures and Single Compounds from
Lentinula edodes
Apart from the isolation of single substances, complexly composed products, so-called multicomponent mixtures (more than one constituent substances, MOCSs), are obtained from the natural materials. A multicomponent mixture contains numerous individual constituents with different functionalities. By using the example of Lentinula edodes (Berk.) Pegler, shiitake, it is shown that this is the case not only for plants but also for medicinal mushrooms. Lentinan, a polysaccharide isolated from the mycelium, is used as a single compound as part of an integrated tumor therapy.
119
28 Feb 2024
Topic Review
Multifaceted Effects of Lycopene
Lycopene is a pigment belonging to the group of carotenoids and it is among the most carefully studied antioxidants found especially in fruit and vegetables. As a carotenoid, lycopene exerts beneficial effects on human health by protecting lipids, proteins, and DNA from damage by oxidation. Lycopene is a powerful oxygen inactivator in the singlet state.
630
17 Nov 2021
Topic Review
Multifaceted Potential of Sulforaphane
Sulforaphane (SFN) is a naturally occurring compound found in cruciferous vegetables such as broccoli and cauliflower. It has been widely studied for its potential as a neuroprotective and anticancer agent. SFN has been shown to exert neuroprotective effects through the activation of the Nrf2 pathway, the modulation of neuroinflammation, and epigenetic mechanisms. In cancer treatment, SFN has demonstrated the ability to selectively induce cell death in cancer cells, inhibit histone deacetylase, and sensitize cancer cells to chemotherapy. SFN has also shown chemoprotective properties through inhibiting phase I metabolizing enzymes, modulating phase II xenobiotic-metabolizing enzymes, and targeting cancer stem cells.
271
18 Dec 2023
Topic Review
Multimodal and Parenteral Analgesia
The combination of non-steroidal anti-inflammatory drugs (NSAIDs) with non-opioid analgesics is common in clinical practice for the treatment of acute painful conditions like post-operative and post-traumatic pain. Despite the satisfactory results achieved by oral analgesics, parenteral analgesia remains a key tool in the treatment of painful conditions when the enteral routes of administration are inconvenient. Parenteral ready-to-use fixed-dose combinations of non-opioid analgesics combinations, including NSAIDs and paracetamol or metamizole, could play a central role in the treatment of painful conditions by combining the advantages of multimodal and parenteral analgesia in a single formulation.
380
14 Aug 2023
Topic Review
Multiple Functions of Melatonin in the Military Setting
Melatonin is a technique that is being increasingly employed to manage growing psycho-physical loads. In this context, melatonin, a pleotropic and regulatory molecule, has a potential preventive and therapeutic role in maintaining the operational efficiency of military personnel. In battlefield conditions in particular, the time to treatment after an injury is often a major issue since the injured may not have immediate access to medical care. Any drug that would help to stabilize a wounded individual, especially if it can be immediately administered (e.g., per os) and has a very high safety profile over a large range of doses (as melatonin does) would be an important asset to reduce morbidity and mortality.
606
06 Feb 2023
Topic Review
Mushrooms as Therapeutic Adjuvant of Cancer Therapies
Mushrooms may act as a potentiator of host defense mechanisms and decrease adverse events in patients with cancer undergoing conventional therapies.
348
21 Feb 2022
Topic Review
MUTYH Gene
The MUTYH gene is located on the short arm of chromosome 1 (1p34.1) and encodes instructions for the MYH glycosylase enzyme.
630
02 Feb 2021
Topic Review
Mycotoxins
Mycotoxins are secondary metabolites produced by fungal species that commonly have a toxic effect on human and animal health. Different foodstuff can be contaminated and are considered the major source of human exposure to mycotoxins, but occupational and environmental exposure can also significantly contribute to this problem.
781
19 Feb 2021
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