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Topic Review
Thin-Layer Chromatography Bioautography
Thin-layer chromatography (TLC) bioautography is a methodological technique that integrates the separation and analysis technology of TLC with biological activity detection technology, which is used to isolate, locate and evaluate the active constituents of natural creatures based on the guidance of activity.
  • 1.6K
  • 06 Aug 2021
Topic Review
Mesenchymal Stem Cell-Derived Extracellular Vesicles for Neurodegenerative Disabilities
Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of biologically active elements, making them a promising approach for therapeutics and diagnostics. 
  • 1.6K
  • 01 Sep 2023
Topic Review
Benefits of Mass Vaccination Programs
Since the late 1940s, mass vaccination programs in the USA have contributed to the significantly reduced morbidity and mortality of infectious diseases. To assist the evaluation of the benefits of mass vaccination programs, the number of individuals who would have suffered death or permanent disability in the USA in 2014, had mass vaccination never been implemented, was estimated for measles, mumps, rubella, tetanus, diphtheria, pertussis, polio, Haemophilus influenzae type b (Hib), hepatitis B, varicella, and human papillomavirus (HPV). The estimates accounted for mortality and morbidity trends observed for these infections prior to mass vaccination and the impact of advances in standard of living and health care. The estimates also considered populations with and without known factors leading to an elevated risk of permanent injury from infection. Mass vaccination prevented an estimated 20 million infections and 12,000 deaths and permanent disabilities in 2014, including 10,800 deaths and permanent disabilities in persons at elevated risk. Though 9000 of the estimated prevented deaths were from liver cirrhosis and cancer, mass vaccination programs have not, at this point, shown empirical impacts on the prevalence of those conditions. Future studies can refine these estimates, assess the impact of adjusting estimation assumptions, and consider additional risk factors that lead to heightened risk of permanent harm from infection.
  • 1.6K
  • 16 Oct 2020
Topic Review
Euphorbia neriifolia Linn.
Medicinal plants have considerable potential as antimicrobial agents due to the presence of secondary metabolites. Researchers aim to summarize the classification, morphology, and ethnobotanical uses of Euphorbia neriifolia L. and its derived phytochemicals with the recent updates on the pharmacological properties against emerging infectious diseases, mainly focusing on bacterial, viral, fungal, and parasitic infections. 
  • 1.6K
  • 14 Jul 2022
Topic Review
Arbutin
Arbutin is a compound with a structure in which one molecule of D-glucose is bound to hydroquinone.
  • 1.6K
  • 18 Aug 2021
Topic Review
Antifungal Therapy
Antifungals (also referred to as antimycotics) are the type of antibiotics used to treat fungal infections. In contrast to bacteria, fungi are eukaryotic organisms; thus fungal cells are very similar to our own cells. Because of this there is a limited number of selective targets and the current arsenal of antifungal drugs is very limited, which contributes to high mortality rates. In addition, development of resistance against current antifungals poses additional challenges. Clearly, new antifungal agents are urgently needed. 
  • 1.6K
  • 22 Oct 2020
Topic Review
Recent Advances in Pterostilbene
Pterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in Dalbergia and Vaccinium spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. Pterostilbene can easily pass through the blood-brain barrier because of its low molecular weight and good liposolubility. In this review, the studies performed in the last three years on resources, synthesis, bioactivity, and pharmacokinetics of pterostilbene are summarized.
  • 1.5K
  • 19 Nov 2020
Topic Review
Lipid and Polymeric Nanoparticles for Brain Drug Delivery
Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety. Nanoparticles have been studied as possible alternatives to conventional formulations, with the objective of improving drug bioavailability.
  • 1.5K
  • 15 Dec 2022
Topic Review
Analytical Assessment of Biosimilars
The analytical assessment includes testing physicochemical and functional attributes to establish a claim of biosimilarity. How closely a biosimilar candidate should match the reference product will remain questionable since a reference product is approved based on whatever quality attributes it presents; a biosimilar candidate, on the other hand, must match these quality attributes, even if the reference product’s attributes are not the most desirable.
  • 1.5K
  • 27 Apr 2022
Topic Review
Sodium Benzoate in Therapies for Nervous System Disorders
One of the compounds known as a preservative with a high safety profile is sodium benzoate. While some studies show that it can be used to treat conditions such as depression, pain, schizophrenia, autism spectrum disorders, and neurodegenerative diseases, others report its harmfulness. For example, it was found to cause mutagenic effects, generate oxidative stress, disrupt hormones, and reduce fertility. 
  • 1.5K
  • 29 Jun 2022
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