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All Topic Review Biography
Topic Review
Novel Antituberculosis Agents
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a curable airborne disease currently treated using a drug regimen consisting of four drugs.
  • 537
  • 21 May 2021
Topic Review
Novel 1,2,4-Oxadiazole Derivatives
Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently accessible drugs containing 1,2,4-oxadiazole unit. It is worth noting that the interest in a 1,2,4-oxadiazoles’ biological application has been doubled in the last fifteen years. Herein, after a concise historical introduction, we present a comprehensive overview of the recent achievements in the synthesis of 1,2,4-oxadiazole-based compounds and the major advances in their biological applications in the period of the last five years as well as brief remarks on prospects for further development.
  • 1.2K
  • 03 Jun 2021
Topic Review
Nonribosomal Peptide and Polyketide Against Human Pathogens
Antibiotics are majorly important molecules for human health. Following the golden age of antibiotic discovery, a period of decline ensued, characterised by the rediscovery of the same molecules. At the same time, new culture techniques and high-throughput sequencing enabled the discovery of new microorganisms that represent a potential source of interesting new antimicrobial substances to explore. 
  • 618
  • 15 Nov 2021
Topic Review
Nonalcoholic Steatohepatitis and Atherosclerosis
Nonalcoholic steatohepatitis (NASH) is the most severe manifestation of nonalcoholic fatty liver disease (NAFLD), a common complication of type 2 diabetes, and may lead to cirrhosis and hepatocellular carcinoma. Oxidative stress and liver cell damage are the major triggers of the severe hepatic inflammation that characterizes NASH, which is highly correlated with atherosclerosis and coronary artery disease. 
  • 332
  • 27 Jun 2022
Topic Review
Non-Viral Gene Delivery Systems
Non-viral materials, such as polymers and lipids, have been developed to create ‘synthetic artificial viruses’ for the delivery of genes into cells in vitro and in vivo. Owing to their limitations in overcoming extra- and intracellular obstacles, these synthetic materials can exhibit poor delivery efficiency relative to viral vectors. However, considering their biocompatibility, high loading capacity, facile fabrication, and potential large-scale production, non-viral vectors have shown great progress in the delivery of gene cargos, especially small interfering RNA (siRNA) molecules.
  • 459
  • 26 Oct 2021
Topic Review
Non-Steroidal CYP17A1 Inhibitors and Prostate Cancer
Abiraterone is the only (as of 2021) CYP17A1 inhibitor approved for the treatment of castrate resistant prostate cancer. It is a molecule based on a steroidal scaffold.
  • 315
  • 18 Feb 2022
Topic Review
Non-Steroidal Anti-Inflammatory Drugs
The non-steroidal anti-inflammatory drugs (NSAIDs) are the most used drugs in knee OA (osteoarthritis) treatment. Despite their efficiency in pain and inflammation alleviation, NSAIDs accumulate in the environment as chemical pollutants and have numerous genetic, morphologic, and functional negative effects on plants and animals. Ultrasound (US) therapy can improve pain, inflammation, and function in knee OA, without impact on environment, and with supplementary metabolic beneficial effects on cartilage compared to NSAIDs. These features recommend US therapy as alternative for NSAIDs use in knee OA treatment. 
  • 523
  • 01 Jun 2021
Topic Review
Non-Dopaminergic Antipsychotic Mechanisms of Neuroleptic Drugs
In 1957, Arvid Carlsson discovered that dopamine, at the time believed to be nothing more than a norepinephrine precursor, was a brain neurotransmitter in and of itself. By 1963, postsynaptic dopamine blockade had become the cornerstone of psychiatric treatment as it appeared to have deciphered the “chlorpromazine enigma”, a 1950s term, denoting the action mechanism of antipsychotic drugs.
  • 121
  • 23 Jan 2024
Topic Review
Non-Alkaloid Cholinesterase Inhibitory Compounds
The classes of cholinesterase inhibitors discussed here are mainly terpenoids, phenolic compounds, and coumarins, and some of these compounds have shown high potency. In order to consider which classes are most suitable, based on the benefits and drawbacks, certain structural features of each class will be of great importance. Using chalcones as an example, it is believed that besides economical and cost-effective production, small molecular size and flexibility for modifications to improve lipophilicity necessary for blood-brain barrier permeability are important to consider for a preferred potential therapeutic candidate for AD.
  • 404
  • 29 Sep 2021
Topic Review
Nod-Like Receptors
The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection.
  • 772
  • 29 Jun 2021
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