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Topic Review
Magnesium Oxide in Constipation
Magnesium oxide has been widely used as an osmotic laxative for a long time especially in East Asia. 
  • 1.1K
  • 04 Mar 2021
Topic Review
Esophageal and Gastric Tumors
Gastric and esophageal tumors are diverse neoplasms that involve mucosal and submucosal tissue layers and include squamous cell carcinomas, adenocarcinomas, spindle cell neoplasms, neuroendocrine tumors, marginal B cell lymphomas, along with less common tumors. The worldwide burden of esophageal and gastric malignancies is significant, with esophageal and gastric cancer representing the ninth and fifth most common cancers, respectively. The approach to diagnosis and staging of these lesions is multimodal and includes a combination of gastrointestinal endoscopy, endoscopic ultrasound, and cross-sectional imaging. Likewise, therapy is multidisciplinary and combines therapeutic endoscopy, surgery, radiotherapy, and systemic chemotherapeutic tools. Future directions for diagnosis of esophageal and gastric malignancies are evolving rapidly and will involve advances in endoscopic and endosonographic techniques including tethered capsules, optical coherence tomography, along with targeted cytologic and serological analyses. 
  • 628
  • 23 Feb 2021
Topic Review
Antimicrobial Resistance in Escherichia coli
Public healthcare systems all over the world are faced with a great challenge in this respect. Obviously, there are many bacteria that can cause infections in humans and animals alike, but somehow it seems that the greatest threat nowadays comes from the Enterobacteriaceae members, especially Escherichia coli.
  • 909
  • 08 Feb 2021
Topic Review
Large Intestine and Its Microbiota
The large intestine (intestinum crassum) is the last part of the digestive tract ensuring the resorption of water, amino acids, bile acids, salts, vitamins and removes unabsorbed residues such as feces. This organ is 1.3–1.4 m long and 5–8 cm wide.
  • 1.2K
  • 07 Feb 2021
Topic Review
Fecal Markers of Inflammation
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the gastrointestinal tract whose etiology is unknown. Pathogenesis of IBD is attributed to the complex interaction of genetic susceptibility, environmental factors (such as smoking, diet, and infections), and the gut microbiota. This results in an uncontrolled immune response leading to mucosal damage. IBDs are characterized by a relapsing and remitting course and require lifelong treatment. Therapy aims to induce remission, maintain remission, and avoid disease progression. Fecal markers are a heterogeneous group of biological substances formed by the inflamed intestinal mucosa or pass through it and enter the intestinal lumen and feces, where they can be measured. The advantage of fecal markers of inflammation over blood markers is that they provide information about the inflammatory process’s location, particularly the location along the gastrointestinal tract. Still, they also are not specific to IBD.
  • 987
  • 05 Feb 2021
Topic Review
CtDNA for Colorectal Cancer
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. While there have been significant developments in the treatments for patients with metastatic CRC in recent years, improving outcomes in the adjuvant setting has been more challenging. Recent technological advances in circulating tumour DNA (ctDNA) assay with the ability to detect minimal residual disease (MRD) after curative intent surgery will fundamentally change how we assess recurrence risk and conduct adjuvant trials. Studies in non-metastatic CRC have now demonstrated the prognostic impact of ctDNA analysis after curative intent surgery over and above current standard of care clinicopathological criteria.
  • 591
  • 03 Feb 2021
Topic Review
Machine Learning in Gastroenterology/Endoscopy
Over time, machine learning (ML), a component of artificial intelligence (AI), has been implemented in a variety of medical specialties, such as radiology, pathology, gastroenterology, neurology, obstetrics and gynecology, ophthalmology, and orthopedics, with the goal of improving the quality of healthcare and medical diagnosis. In clinical gastroenterology practice, due to technological developments, estimates show that AI could have the ability to create a predictive model; for instance, it could develop an ML model that can stratify the risk in patients with upper gastrointestinal bleeding, establish the existence of a specific gastrointestinal disease, define the best treatment, and offer prognosis and prediction of the therapeutic response. In this context, by applying ML or deep learning (DL) (AI using neural networks), clinical management in gastroenterology can begin to focus on more personalized treatment centered on the patient and based on making the best individual decisions, instead of relying mostly on guidelines developed for a specific condition. Moreover, the goal of implementing these AI-based algorithms is to increase the possibility of diagnosing a gastrointestinal disease at early stage or the ability to predict the development of a particular condition in advance. Because both AI and gastroenterology encompass many subdomains, the interaction between them might take on various forms. In recent years, we have witnessed a large explosion of research in attempts to improve various fields of gastroenterology, such as endoscopy, hepatology, inflammatory bowel diseases, and many others, with the aid of ML. We also note that, because of the requirement to diagnose more patients with gastrointestinal cancers at an early stage of the disease, which is associated with curative treatment and better prognosis, many studies were developed to address improvement of the detection of these tumors with the aid of AI. The term ML, introduced for the first time in 1959 by Arthur Samuel from the IBM company, refers to an IT domain whereby a computer system can acquire the ability to “learn” by using data without specific programming and can therefore develop a predictive mathematical algorithm based on input data, using recognition of “features”. The ML “model” is subsequently able to adapt to new situations in which it becomes able to predict and make decisions.
  • 1.1K
  • 02 Feb 2021
Topic Review
Vitamin D, microbiome, and IBD
Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract (GIT), including Crohn’s disease (CD) and ulcerative colitis (UC), which differ in the location and lesion extensions. Both diseases are associated with microbiota dysbiosis, with a reduced population of butyrate-producing species, abnormal inflammatory response, and micronutrient deficiency (e.g., vitamin D hypovitaminosis). Vitamin D (VitD) is involved in immune cell differentiation, gut microbiota modulation, gene transcription, and barrier integrity. Vitamin D receptor (VDR) regulates the biological actions of the active VitD (1α,25-dihydroxyvitamin D3), and is involved in the genetic, environmental, immune, and microbial aspects of IBD. VitD deficiency is correlated with disease activity and its administration targeting a concentration of 30 ng/mL may have the potential to reduce disease activity. Moreover, VDR regulates functions of T cells and Paneth cells and modulates release of antimicrobial peptides in gut microbiota-host interactions. Meanwhile, beneficial microbial metabolites, e.g., butyrate, upregulate the VDR signaling.
  • 798
  • 31 Jan 2021
Topic Review
Okara and Gut
Okara is a white-yellow fibrous residue consisting of the insoluble fraction of the soybean seeds remaining after extraction of the aqueous fraction during the production of tofu and soymilk, and is generally considered a waste product. It is packed with a significant number of proteins, isoflavones, soluble and insoluble fibers, soyasaponins, and other mineral elements, which are all attributed with health merits. With the increasing production of soy beverages, huge quantities of this by-product are produced annually, which poses significant disposal problems and financial issues for producers. Extensive studies have been done on the biological activities, nutritional values, and chemical composition of okara as well as its potential utilization. Owing to its peculiar rich fiber composition and low cost of production, okara might be potentially useful in the food industry as a functional ingredient or good raw material and could be used as a dietary supplement to prevent varied ailments such as prevention of diabetes, hyperlipidemia, obesity, as well as to stimulate the growth of intestinal microbes and production of microbe-derived metabolites (xenometabolites), since gut dysbiosis (imbalanced microbiota) has been implicated in the progression of several complex diseases.
  • 3.6K
  • 31 Jan 2021
Topic Review
MoRAL-AI: AI-based Liver Transplantation Model
Novel model to predict HCC recurrence after liver transplantation based on deep learning
  • 764
  • 29 Jan 2021
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