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Topic Review
Adzuki Bean Alleviates Obesity
Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied. Mice were fed a low-fat diet, a HFD, and a HFD supplemented with 15% adzuki bean (HFD-AB) for 12 weeks. Adzuki bean supplementation significantly reduced obesity, lipid accumulation, and serum lipid and lipopolysaccharide (LPS) levels induced by HFD. It also mitigated liver function damage and hepatic steatosis. In particular, adzuki bean supplementation improved glucose homeostasis by increasing insulin sensitivity. In addition, it significantly reversed HFD-induced gut microbiota imbalances. Adzuki bean significantly reduced the ratio of Firmicutes/Bacteroidetes (F/B); enriched the occurrence of Bifidobacterium, Prevotellaceae, Ruminococcus_1, norank_f_Muribaculaceae, Alloprevotella, Muribaculum, Turicibacter, Lachnospiraceae_NK4A136_group, and Lachnoclostridium; and returned HFD-dependent taxa (Desulfovibrionaceae, Bilophila, Ruminiclostridium_9, Blautia, and Ruminiclostridium) back to normal status. PICRUSt2 analysis showed that the changes in gut microbiota induced by adzuki bean supplementation may be associated with the metabolism of carbohydrates, lipids, sulfur, and cysteine and methionine; and LPS biosynthesis; and valine, leucine, and isoleucine degradation. 
  • 594
  • 28 Sep 2021
Topic Review
Aerobic Exercise Facilitate Vaping and Smoking Cessation
Cigarette smokers try to quit using several strategies including electronic cigarette use (vaping). An alternative, easy and cheap method is exercise. However, little is known about the efficacy of aerobic exercise (AE) to augment smoking and vaping cessation. One such potential alternative smoking cessation (SC) intervention is aerobic exercise. Exercise interventions are categorised as, e.g., aerobic, strengthening or relaxation exercises. Exercise is easy to access and cheap and therefore one may consider exercise as a viable intervention to facilitate SC, particularly via the reduction in nicotine withdrawal symptoms and cigarette craving
  • 440
  • 10 Nov 2022
Topic Review
Aeroterrestrial and Extremophilic Microalgae as Sources in Cosmetics
Microscopic prokaryotic and eukaryotic algae (microalgae), which can be effectively grown in mass cultures, are gaining increasing interest in cosmetics. Up to now, the main attention was on aquatic algae, while species from aeroterrestrial and extreme environments remained underestimated. In these habitats, algae accumulate high amounts of some chemical substances or develop specific compounds, which cause them to thrive in inimical conditions. Among such biologically active molecules is a large family of lipids, which are significant constituents in living organisms and valuable ingredients in cosmetic formulations. Therefore, natural sources of lipids are increasingly in demand in the modern cosmetic industry and its innovative technologies. Among novelties in skin care products is the use of lipid nanoparticles as carriers of dermatologically active ingredients, which enhance their penetration and release in the skin strata. 
  • 615
  • 29 Mar 2022
Topic Review
Aesthetic Medicine Safety for Autoimmune Thyroid Disease patients
Autoimmune thyroid diseases are the most common organ-specific autoimmune diseases, affecting 2–5% of the world’s population. Due to the autoimmune background of thyroid diseases, we analyzed a wide range of cosmetic procedures, from minimally invasive cosmetic injections (mesotherapy) to highly invasive procedures, such as lifting threads. Out of the seven categories of treatments in aesthetic medicine analyzed by us—hyaluronic acid, botulinum toxin, autologous platelet-rich plasma, autologous fat grafting, lifting threads, IPL and laser treatment and mesotherapy—only two, mesotherapy and lifting threads, are not recommended.
  • 440
  • 19 Jan 2022
Topic Review
Aetiology and Pathogenesis of Vitiligo
Vitiligo is an acquired, chronic condition characterised by depigmentation of the epidermis or by destruction/loss of melanin. Skin cells (melanocytes) are responsible for producing melanin, the substance that gives pigmentation to the skin. Although there is no specific ethnic group, gender, or skin type that is more prone to vitiligo than others, it can affect anyone. Even though vitiligo is typically thought of as a cosmetic disorder, its effects on the physical and psychosocial health of sufferers cannot be ignored.
  • 389
  • 09 Jun 2023
Topic Review
Aetiology and Pathophysiology of Parkinson’s and Alzheimer’s Disease
Neurodegeneration is hallmarked by the progressive loss of dopaminergic neurons and/or a significant increase in protein aggregates in the brain. Neurodegenerative diseases are a leading cause of death worldwide with over 15 million people currently suffering from either Parkinson’s disease (PD) or Alzheimer’s disease (AD). PD is often characterized by both motor and non-motor symptoms, including muscle rigidity, tremors and bradykinesia, with AD displaying symptoms of confusion and dementia.
  • 680
  • 22 Mar 2023
Topic Review
Aetiology of Bicuspid Aortic Valve
BAV (Bicuspid Aortic Valve) stands as the most prevalent congenital heart condition closely linked to critical and potentially life-threatening cardiac and aortic ailments, including aortic stenosis, aortic insufficiency, aortic aneurysms, and aortic dissection. It is believed that both genetic and epigenetic factors influence the etiology of BAV. Gaining insight into this underlying causative framework is paramount in guiding treatment strategies for BAV and its associated pathologies.
  • 447
  • 12 Oct 2023
Topic Review
Affect and Personality in Fibromyalgia
Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread and persistent musculoskeletal pain, which is usually associated with other symptoms such as fatigue, tiredness, insomnia, stiffness, cognitive deficits, and emotional comorbidities (i.e., depression and anxiety). FMS patients usually display a high rate of psychiatric disorders compared to the general population. FMS has been also associated with higher levels of negative affect and lower levels of positive affect. High levels of stress, pain catastrophizing, and angry rumination have been also reported in FMS patients. Additionally, there are a tendency to internalize and suppress anger in FMS patients. Regarding personality in FMS, some studies have observed some FMS features (e.g., high impulsivity, harm avoidance, self-transcendence and neuroticism, and low conscientiousness, cooperativeness and self-directedness), while other authors had not found any particular personality trait. Some personality disorders (i.e., obsessive-compulsive personality disorder, borderline personality, avoidant personality disorder, and histrionic personality disorder) seem to be more frequent in FMS patients than in general population. Moreover, previous research has reported a greater presence of the type D personality and high levels of alexithymia in a significant proportion of FMS patients. It is necessary to improve the understanding of the role of affect and personality in the clinical practice with chronic pain patients, in order to improve the success of a personalized oriented treatment and increase their health-related quality of life.
  • 6.7K
  • 27 Oct 2020
Topic Review
Affective Disturbance in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic, inflammatory synovitis-based systemic immune disease of unknown etiology. In addition to joint pathological damage, RA has been linked to neuropsychiatric comorbidities, including depression, schizophrenia, and anxiety, increasing the risk of neurodegenerative diseases in life.
  • 663
  • 04 Aug 2022
Topic Review
Aflatoxins
Aflatoxins family includes a great number of lipophilic molecules produced by aerobic micro fungi belonging to the genus Aspergillus. Aflatoxins are secondary metabolites produced by the microfungi.
  • 1.2K
  • 06 Nov 2020
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