Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Acute Myocardial Infarction in COVID-19
Coronavirus disease 2019 (COVID-19) has quickly become a worldwide health crisis. Although respiratory disease remains the main cause of morbidity and mortality in COVID patients, myocardial damage is a common finding. Many possible biological pathways may explain the relationship between COVID-19 and acute myocardial infarction (AMI). Increased immune and inflammatory responses, and procoagulant profile have characterized COVID patients. All these responses may induce endothelial dysfunction, myocardial injury, plaque instability, and AMI. Disease severity and mortality are increased by cardiovascular comorbidities. However, a marked fall in AMI admissions has been observed during lockdown, likely due, almost in part, to fear of in-hospital infection. Thus, attention should be also directed to psychological distress and fear, as COVID19 indirect effects on no-COVID diseases can be more harmful than the infection itself.
  • 815
  • 26 Oct 2020
Topic Review
Photocatalysis of COVID-19 in Wastewater
The coronavirus (COVID-19) pandemic is currently posing a significant threat to the world’s public health and social-economic growth. Despite the rigorous international lockdown and quarantine efforts, the rate of COVID-19 infectious cases remains exceptionally high. Notwithstanding, the end route of COVID-19, together with emerging contaminants’ (antibiotics, pharmaceuticals, nanoplastics, pesticide, etc.) occurrence in wastewater treatment plants (WWTPs), poses a great challenge in wastewater settings.
  • 815
  • 09 Oct 2020
Topic Review
Homologous Recombination Deficiency in Cancer
Homologous Recombination Deficiency (HRD) is associated with sensitivity towards PARP inhibitors (PARPi) and its determination is used as a biomarker for therapy decision making.
  • 815
  • 26 Jul 2021
Topic Review
Optical Coherence Tomography in Myopia and Pathologic Myopia
Myopia represents a growing and significantly global public health problem, with a prevalence of over two billion people (28.3% of the global population), including 277 million individuals (4.0%) with high myopia. Pathologic myopia is defined by the presence of myopic lesions in the posterior segment of the eye (posterior staphyloma or myopic maculopathy equal to or more serious than diffuse choroidal atrophy). Advances in imaging with optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) technology, including the development of swept source OCT/OCTA, widefield or ultra-widefield systems, have greatly improved the understanding, diagnosis, and treatment of myopia and myopia-related complications.
  • 815
  • 17 Jun 2022
Topic Review
Hearing Impairment
Hearing impairment (HI), also referred to as hearing loss, is the partial or total loss of hearing. GJB2 is the most common gene associated with HI and it belongs to a family of genes that encodes connexin proteins. Over seven connexins (GJB3, GJB4, GJC3, GJC1, GJB2, GJB6, and GJA1) have been globally studied for their association with HI, however, the majority did not have a clearly established association with the condition. Although there were studies that reported variants in  GJB3, GJB4, GJC3, and GJC1 in hearing-impaired patients, there is a need for more studies to clearly describe their role in the development of HI. GJB2, GJB6, and GJA1 on the other hand have been identified as HI genes that should be considered in routine clinical investigations. Recent data has shown that the coding region variants of GJB6 (except the large genomic deletions) do not contribute to the development of HI.
  • 815
  • 12 Nov 2020
Topic Review Peer Reviewed
SARS, MERS and COVID-19-Associated Renal Pathology
Coronaviruses are a large group of RNA viruses, the most notable representatives of which are SARS-CoV, MERS-CoV and SARS-CoV-2. Human coronavirus infections were first documented in the 1960s, when members causing seasonal common colds were successfully replicated in human embryonal trachea and kidney cell cultures and classified based on electron microscopy. The history of coronaviruses stretched far back to that point, however, with some representatives causing disease in animals identified several decades prior and evolutionary data pointing towards the origin of this viral group more than 55 million years ago. In the short time period of research since they were discovered, coronaviruses have shown significant diversity, genetic peculiarities and varying tropism, resulting in the three identified causative agents of severe disease in humans—SARS, MERS and the most recent one, COVID-19, which has surpassed the previous two due to causing a pandemic resulting in significant healthcare, social and political consequences. Coronaviruses are likely to have caused pandemics long before, such as the so-called Asian or Russian influenza. Despite being epitheliotropic viruses and predominantly affecting the respiratory system, these entities affect multiple systems and organs, including the kidneys. In the kidneys, they actively replicate in glomerular podocytes and epithelial cells of the tubules, resulting in acute kidney injury, seen in a significant percentage of severe and fatal cases. Furthermore, the endothelial affinity of the viruses, resulting in endotheliitis, increases the likelihood of thrombotic microangiopathy, damaging the kidneys in a two-hit mechanism. As such, recently, COVAN has been a suggested nomenclature change indicating renal involvement in coronavirus infections and its long-lasting consequences. 
  • 815
  • 10 Oct 2022
Topic Review
Sperm Selection for Intracytoplasmic Sperm Injection
Intracytoplasmic sperm injection (ICSI) is the method that has definitely revolutionized the field of ART since normal fertilization and ongoing pregnancies can be achieved even with low quality sperm samples and affected spermatozoa. By injecting a single sperm cell in the oocyte, the technique bypasses several biological barriers that naturally select the gametes to achieve optimal embryonic and fetal development.
  • 814
  • 10 Jan 2022
Topic Review
Nutritional Therapies on the Intestinal Microbiome
Inflammatory bowel disease (IBD) is a chronic, autoimmune disorder of the gastrointestinal tract with numerous genetic and environmental risk factors. Patients with Crohn’s disease (CD) or ulcerative colitis (UC) often demonstrate marked disruptions of their gut microbiome. The intestinal microbiota is strongly influenced by diet. The association between the increasing incidence of IBD worldwide and increased consumption of a westernized diet suggests host nutrition may influence the progression or treatment of IBD via the microbiome. Several nutritional therapies have been studied for the treatment of CD and UC. While their mechanisms of action are only partially understood, existing studies do suggest that diet-driven changes in microbial composition and function underlie the diverse mechanisms of nutritional therapy. Despite existing therapies for IBD focusing heavily on immune suppression, nutrition is an important treatment option due to its superior safety profile, potentially low cost, and benefits for growth and development. These benefits are increasingly important to patients. In this entry, we will describe the clinical efficacy of the different nutritional therapies that have been described for the treatment of CD and UC. 
  • 814
  • 05 Jan 2022
Topic Review
Epithelial to Mesenchymal Transition
Pancreatic ductal adenocarcinoma (PDAC) is one of the malignancies with the worst prognosis despite a decade of efforts. The effectiveness of PDAC therapies is challenged by the early and widespread metastasis. Epithelial to mesenchymal transition (EMT) is a major driver of cancer progression and metastasis. 
  • 814
  • 05 Aug 2021
Topic Review
Astrocytes in Depression and Alzheimer’s Disease
Astrocytes play a key role in the functioning of neurons in norm and pathology, being a target for stress and glucocorticoids, are a promising target for the treatment of stress-dependent depression and Alzheimer’s disease (AD). Depression, as a mental disorder, is characterized by two core symptoms, depressed mood and loss of interest or pleasure in nearly all activities, and may be accompanied by other symptoms such as cognitive impairments, sleep disturbance, psychomotor retardation or agitation, feelings of worthlessness or excessive or inappropriate guilt.
  • 814
  • 20 May 2022
  • Page
  • of
  • 1353
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback