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Topic Review
Tea and Its Active Constituents in Cosmetics
Tea plant itself and its extracts together with their centuries-old tradition of use play an important role on the cosmetics market. In general, cosmetics products containing tea extracts rich in polyphenols have a positive effect on the skin appearance and ameliorate skin damage, erythema and lipid peroxidation following UV exposure.
  • 1.2K
  • 29 Mar 2022
Topic Review
Lockdown, Clinical Characteristics and Diagnostic Challenges of COVID-19
The entire world is facing lockdown due to coronaviruses has been noticed.  The outbreak of such coronavirus, known as COVID-19 came existence since late 2019 and early 2020. The first reported coronavirus patient was from Wuhan, China, on December 31, 2019. It was very rapidly spread across the world and killed several lives. Coronavirus looks very dangerous because there is no specific treatment and no vaccine came on this planet earth. It has been reported that coronaviruses appear to attack lung cells. Cells infected the coronaviruses generate more virus particles. These virus particles can then spread to other people by means of coughing and even aerosol transmission was also noticed in two Wuhan hospitals during the outbreak of COVID-19 in the months of February and March 2020.
  • 1.2K
  • 06 Mar 2021
Topic Review
The Coming of Age of Biosimilars
The first biosimilar, Sandoz’s Omnitrope  (human growth hormone), was approved in 2006 by both the FDA and EMA; it was approved by the FDA under the 505(b)(2) generic product legislation and by the EU as a biosimilar. Later, Sandoz received the first licensing of Zarzio/Zarxio (filgrastim) in 2015; this was the first biosimilar product approved under the 351(k) BLA legislation in the US. Biosimilars have come of age from 2005 to the present, with 84 approvals in the EU and 35 in the US, representing almost 90% of the world market. While the acceptance of biosimilars in the US is catching up with that in the EU, the cost benefits remain elusive due to the high development barrier and complex distribution system involved, mainly in the US. In the EU, the cost of biosimilars has already dropped 70% or more, and interchangeability is a routine in some European jurisdictions, unlike in the US, where a separate regulatory approval is required.
  • 1.2K
  • 27 Apr 2022
Topic Review
Brain Barriers
Barriers between the brain and systemic circulation are dynamic and highly specialized to strictly regulate the access of a wide variety of molecules to the brain. These barriers allow for the delivery of nutrients and other molecules necessary for neuronal functioning, but often limit the permeation of xenobiotics, including drugs. In brain tumors, these barrier functions may be disrupted or altered. However, this disruption is often heterogeneous and not reliable to guaranteee the delivery of efficacious concentrations of antineoplastic agents to brain tumors.
  • 1.2K
  • 11 Jan 2021
Topic Review
Health and Oral Health Coaching
Health-related behavior based on diet is an important determinant of oral health in independent elderly. Aging impairs senses, mastication, oral status, and function, causing nutritional needs and diet insufficiencies that contribute to a vicious circle of impairment. But the present needs of independent older adults suggest that health research and oral health care should shift from disease management and therapy to integral customized and personal treatment plans, including lifestyle, psychological, nutritional, and oral health coaching approaches. In this paper health coaching approaches in medical and dental settings are valued as to their effectiveness for older adults. Furthermore, coaching approaches for seniors are discussed and coaching models for better senior patient-dentist cooperation on the diet issue are suggested. Diet and oral health coaching is proven to be a modern senior patient-centered approach that needs to be incorporated at all relevant settings. It should aim to empower older adults in co-management of their oral diseases or bad diet habits affecting their oral health. This can be carried out through an incorporated educational plan for dentists either at the postgraduate or professional level since advantages seem to enhance the quality of life of the independent elderly.
  • 1.2K
  • 31 Jan 2022
Topic Review
Extracellular Matrix in Breast Cancer
The role of extracellular matrix in breast cancer progression has recently been realized. Here, the effect of various ECM properties including fiber structure, stiffness and biochemical composition are reviewed, with a special emphasis on the extracellular vesicles. 
  • 1.2K
  • 16 Oct 2020
Topic Review
DUBs Activating Hedgehog Signaling Pathway
The Hedgehog (HH) pathway governs cell proliferation and patterning during embryonic development and is involved in regeneration, homeostasis and stem cell maintenance in adult tissues. The activity of this signaling is finely modulated at multiple levels and its dysregulation contributes to the onset of several human cancers. Ubiquitylation is a coordinated post-translational modification that controls a wide range of cellular functions and signaling transduction pathways. It is mediated by a sequential enzymatic network, in which ubiquitin ligase (E3) and deubiquitylase (DUBs) proteins are the main actors. The dynamic balance of the activity of these enzymes dictates the abundance and the fate of cellular proteins, thus affecting both physiological and pathological processes. Several E3 ligases regulating the stability and activity of the key components of the HH pathway have been identified. Further, DUBs have emerged as novel players in HH signaling transduction, resulting as attractive and promising drug targets.
  • 1.2K
  • 04 Feb 2021
Topic Review
Microbiota for HPV Infection
The microbiome is able to modulate immune responses, alter the physiology of the human organism, and increase the risk of viral infections and development of diseases such as cancer. Herein, we address changes in the cervical microbiota as potential biomarkers to identify the risk of cervical intraepithelial neoplasia (CIN) development and invasive cervical cancer in the context of human papillomavirus (HPV) infection.
  • 1.2K
  • 30 Oct 2020
Topic Review
Prostaglandin E2 and cancer
The involvement of inflammation in cancer progression has been the subject of research for many years. Inflammatory milieu and immune response are associated with cancer progression and recurrence. In different types of tumors, growth and metastatic phenotype characterized by the epithelial mesenchymal transition (EMT) process, stemness, and angiogenesis, are increasingly associated with intrinsic or extrinsic inflammation. Among the inflammatory mediators, prostaglandin E2 (PGE2) supports epithelial tumor aggressiveness by several mechanisms, including growth promotion, escape from apoptosis, transactivation of tyrosine kinase growth factor receptors, and induction of angiogenesis. Moreover, PGE2 is an important player in the tumor microenvironment, where it suppresses antitumor immunity and regulates tumor immune evasion, leading to increased tumoral progression.
  • 1.2K
  • 11 Dec 2020
Topic Review
DNA Damage Repair for Cancer
DDR is activated in response to different endogenous and exogenous stresses(). When aberrantly repaired, DNA damage might be associated with clinical outcomes such as neurodegeneration, infertility, and genomic instability, being a key contributing factor to neoplastic transformation and tumour development(). Due to the complexity underneath detection and repair of DNA damage, cells evolved an intricate DDR network that, together with cell cycle regulation, promotes the maintenance of genomic stability and cellular viability().
  • 1.2K
  • 02 Aug 2021
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