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Topic Review
Different Nerve-Sparing Techniques during Radical Prostatectomy
Nerve-sparing technique during RP has a major impact to both oncological and functional outcomes of the procedure and various different techniques have been developed aiming to optimize its outcomes. Nerve-sparing techniques can be distinguished based on the fascial planes of dissection (intrafascial, interfascial or extrafascial), the direction of dissection (retrograde or antegrade), the timing of the neurovascular bundle dissection off the prostate (early vs. late release), the use of cautery, the application of traction and the number of the neurovascular bundles which are preserved.
  • 1.3K
  • 18 Apr 2022
Topic Review
The Modified Phenanthridine PJ34
This entry summarizes recent data disclosing the efficacy of the modified phenanthridine PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. 
  • 1.3K
  • 19 Sep 2020
Topic Review
Natural Antimicrobial Products
Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are an invaluable source of antimicrobial compounds. The antimicrobial activity of the most representative natural products of animal, bacterial, fungal and plant origin are reviewed in this article. Their activity against drug-resistant bacteria, their mechanisms of action, the possible development of resistance against them, their role in current medicine and their future perspectives are discussed. Natural compounds of heterogeneous origins have been shown to possess antimicrobial capabilities, including against antibiotic-resistant bacteria. The most commonly found mechanisms of antimicrobial action are related to protein biosynthesis and alteration of cell walls and membranes. Various natural compounds, especially phytochemicals, have shown synergistic capacity with antibiotics. There is little literature on the development of specific resistance mechanisms against natural antimicrobial compounds. New technologies such as -omics, network pharmacology and informatics have the potential to identify and characterize new natural antimicrobial compounds in the future. This knowledge may be useful for the development of future therapeutic strategies.
  • 1.3K
  • 05 Jan 2021
Topic Review
Natural Language Processing for Telehealth
The natural language processing (NLP) technology can serve as an interaction between computers and humans using linguistic analysis and deep learning methods to obtain knowledge from an unstructured free text. The NLP systems have shown their uniqueness and importance in the areas of information retrieval mostly in the retrieval and processing of large amount of unstructured clinical records and return structured information by user-defined queries. In general, the NLP system is aimed at representing explicitly the knowledge that is expressed by the text written in a natural language. 
  • 1.3K
  • 18 Sep 2021
Topic Review
Amorphization of Poorly Water-Soluble Drugs
Amorphization technology has been the subject of continuous attention in the pharmaceutical industry, as a means to enhance the solubility of poorly water-soluble drugs. Being in a high energy state, amorphous formulations generally display significantly increased apparent solubility as compared to their crystalline counterparts, which may allow them to generate a supersaturated state in the gastrointestinal tract and in turn, improve the bioavailability. Conventionally, hydrophilic polymers have been used as carriers, in which the amorphous drugs were dispersed and stabilized to form polymeric amorphous solid dispersions. However, the technique had its limitations, some of which include the need for a large number of carriers, the tendency to recrystallize during storage, and the possibility of thermal decomposition of the drug during preparation. Therefore, emerging amorphization technologies have focused on the investigation of novel amorphous-stabilizing carriers and preparation methods that can improve the drug loading and the degree of amorphization. 
  • 1.3K
  • 08 Sep 2021
Topic Review
Melatonin as a Neurotrophic Factor
Melatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal environment with the photoperiod. It is synthesized in the pineal gland and greatly depends on the endogenous circadian clock located in the suprachiasmatic nucleus and the retina’s exposure to different light intensities. Among its most studied functions are the regulation of the waking-sleep rhythm and body temperature. Furthermore, melatonin has pleiotropic actions, which affect, for instance, the modulation of the immune and the cardiovascular systems, as well as the neuroprotection achieved by scavenging free radicals.
  • 1.3K
  • 19 Nov 2022
Topic Review
Protein-Energy Wasting: Acute Kidney Injury
Acute kidney injury is a heterogeneous group of conditions characterised by a sudden decrease in glomerular filtration rate, manifested by an increase in serum creatinine concentration or oliguria. Protein energy wasting is a state of decreased body stores of protein and energy fuels.
  • 1.3K
  • 27 Oct 2020
Topic Review
Drama Therapy
Drama therapy is the use of theatre techniques to facilitate personal growth and promote mental health. Drama therapy is used in a wide variety of settings, including hospitals, schools, mental health centers, prisons, and businesses. Drama therapy, as a modality of the creative arts therapies, exists in many forms and can apply to individuals, couples, families, and various groups.
  • 1.3K
  • 23 Nov 2022
Topic Review
Comfort Food
Comfort food is food that provides a nostalgic or sentimental value to someone, and may be characterized by its high caloric nature, high carbohydrate level, or simple preparation. The nostalgia may be specific to an individual, or it may apply to a specific culture.
  • 1.3K
  • 24 Nov 2022
Topic Review
Inner Ear Malformations
Inner ear malformations are a spectrum of congenital anomalies involving the inner ear structures with an emphasis on the cochlea due to their implications for sensorineural hearing loss.
  • 1.3K
  • 03 Nov 2021
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