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Topic Review
Radiology and Imaging Diagnosis of Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory neurological illness common in young adults. The prevalence and incidence of MS are regionally and globally increasing. MRI scans are important for diagnosis and regular follow-up to monitor treatment response and disease progression. Interpretation of MRI scans should be performed by experienced radiologists who are familiar with the patient’s clinical and laboratory data, and who are able to detect evidence supporting or refuting a diagnosis of MS.
  • 347
  • 05 Jun 2023
Topic Review
Retinitis Pigmentosa - Stem Cell Therapy and Optogenetics
Retinitis pigmentosa (RP) is a hereditary disease that causes the gradual degeneration of the photoreceptor cells in the retina, starting with the rods, leading to a progressive loss of vision over time. RP is the most prevalent form of inherited retinal dystrophy, affecting over 1.5 million individuals worldwide and significantly impacting both patients and society. RP is a primary cause of visual disability and blindness in people under 60 years old, and common symptoms include nyctalopia and gradual peripheral vision loss. If left untreated, RP can ultimately lead to complete blindness.
  • 286
  • 05 Jun 2023
Topic Review
Copper-Based Radiopharmaceuticals for Radioimmunotherapy
Copper-64 (T1/2 = 12.7 h) is a positron and beta-emitting isotope, with decay characteristics suitable for both positron emission tomography (PET) imaging and radiotherapy of cancer. Copper-67 (T1/2 = 61.8 h) is a beta and gamma emitter, appropriate for radiotherapy β-energy and with a half-life suitable for single-photon emission computed tomography (SPECT) imaging. The chemical identities of 64Cu and 67Cu isotopes allow for convenient use of the same chelating molecules for sequential PET imaging and radiotherapy. 
  • 438
  • 02 Jun 2023
Topic Review
Ulvan As a Seaweed-Derived Sulfated Polysaccharide
Cancer is one of the most worldwide spread diseases and causes maximum death. Treatment of cancer depends on the host immune system and the type of drugs. The inefficiency of conventional cancer treatments as a result of drug resistance, nontargeted delivery, and chemotherapy-related negative side effects has caused bioactive phytochemicals to come into focus. Ulvan is a polysaccharide derived from various green seaweeds of the Ulva species in the family Ulvaceae. It has been demonstrated to have potent anticancer and anti-inflammatory properties through the modulation of antioxidants. It is vital to understand the mechanisms underlying the biotherapeutic activities of Ulvan in cancer and its role in immunomodulation.
  • 458
  • 02 Jun 2023
Topic Review
Chronic Hepatitis E
Hepatitis E is an inflammation of the liver caused by infection with the hepatitis E virus (HEV), and it is a major cause of acute viral hepatitis worldwide, the virus is usually transmitted via the fecal–oral route, principally via contaminated water. Chronic hepatitis E (CHE) has been identified as associated with chronic liver damage induced by HEV genotypes 3, 4, and 7—usually in immunocompromised patients such as transplant recipients. In addition, patients infected with HIV and those receiving chemotherapy for malignancy, along with patients with rheumatic disease and COVID-19, have been reported as having CHE. 
  • 332
  • 02 Jun 2023
Topic Review
Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma
Systemic therapeutic agents, including combination immunotherapy, could promote a change in the treatment strategy in patients with advanced hepatocellular carcinoma (HCC). Hepatic arterial infusion chemotherapy (HAIC) is highly effective in patients with vascular invasion compared with sorafenib.
  • 286
  • 02 Jun 2023
Topic Review
Inheritance of Microbiome-Deficiency
Like the majority of non-communicable diseases that have recently gained attention, functional gastrointestinal (GI) disorders (FGID) in both children and adults are caused by a variety of medical conditions. In general, while it is often thought that common conditions such as obesity may cause other problems, for example, asthma or mental health issues, more consideration needs to be given to the possibility that they could both be brought on by a single underlying problem. Based on the variations in non-communicable disease, in recent years, researchers group has been revisiting the exact role of the intestinal microbiome within the Vertebrata.
  • 252
  • 02 Jun 2023
Topic Review
Mechanism of Adjuvanticity
Vaccines have been extraordinary resources to prevent pathogen diffusion and cancer. Even if they can be formed by a single antigen, the addition of one or more adjuvants represents the key to enhance the response of the immune signal to the antigen, thus accelerating and increasing the duration and the potency of the protective effect. Their use is of particular importance for vulnerable populations, such as the elderly or immunocompromised people.
  • 492
  • 01 Jun 2023
Topic Review
Annular Erythemas and Purpuras
Annular dermatoses (AD) are a heterogeneous group of skin diseases, whose common feature is essentially the annular or circular arrangement of the lesions with centrifugal spreading. They belong to the group of figurate dermatoses, to which can be added linear or serpiginous dermatoses, for example. They are a fascinating curiosity for the dermatologist, as they form patterns and arabesques on the patient’s body.
  • 1.7K
  • 01 Jun 2023
Topic Review
CAR-T Cells Immunotherapies for Acute Myeloid Leukemia Therapy
The CAR is composed of four regions, namely: the extracellular antigen-binding domain usually made of a single-chain variable fragment (scFv), the hinge (the spacer region), which increases flexibility and allows the CAR to be properly matched to the target antigen, the transmembrane domain, and the intracellular signaling domain. The CAR construct was modified so as to increase the efficiency and expansion of CAR-T cells in the immunosuppressive tumor microenvironment (TME). AML is a malignancy of the hematopoietic system of a heterogeneous nature. The disease is caused by mutations resulting in the proliferation of cancer cells derived from progenitor cells of the myeloid lineage.
  • 476
  • 01 Jun 2023
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