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Topic Review
Biography
Topic Review
Soluble Suppression of Tumorigenicity-2 in Heart Failure
There has been growing interest in the risk stratification for heart failure, and the use of multiple biomarkers to identify different pathophysiological processes associated with this condition. One such biomarker is soluble suppression of tumorigenicity-2 (sST2), which has shown some potential for integration into clinical practice. sST2 is produced by both cardiac fibroblasts and cardiomyocytes in response to myocardial stress. Other sources of sST2 are endothelial cells of the aorta and coronary arteries and immune cells such as T cells.
208
14 Jun 2023
Topic Review
Post COVID-19 Syndrome
Chronic obstructive pulmonary disease (COPD) is significant cause of morbidity and mortality worldwide. There is mounting evidence suggesting that COPD patients have been identified as a high-risk group for severe post-COVID-19 syndrome
398
14 Jun 2023
Topic Review
Acne-Like Eruptions
The term “acne-like eruptions” encompasses a variety of skin conditions resembling acne vulgaris. While both acne-like dermatoses and true acne are frequently observed in clinical settings, differentiating between the two might be challenging. Similar to acne, the lesions of acne-like eruptions may exhibit papules, pustules, nodules, and cysts.
334
14 Jun 2023
Topic Review
MINOCA Associated with a Myocardial Bridge
Myocardial bridging (MB) is the most frequent congenital coronary anomaly characterized by a segment of an epicardial coronary artery that passes through the myocardium. MB is an important cause of myocardial ischemia and is also emerging as a possible cause of myocardial infarction with non-obstructed coronary arteries (MINOCA). There are multiple mechanisms underlying MINOCA in patients with MB (i.e., MB-mediated increased risk of epicardial or microvascular coronary spasm, atherosclerotic plaque disruption and spontaneous coronary artery dissection).
384
13 Jun 2023
Topic Review
Treat-to-Target in Systemic Lupus Erythematosus
Treat-to-target is a therapeutic approach based on adjustments to treatment at set intervals in order to achieve well-defined, clinically relevant targets. This approach has been successfully applied to many chronic conditions, and in rheumatology promising results have emerged for rheumatoid arthritis. For systemic lupus erythematosus (SLE), defining the most meaningful treatment targets has been challenging, due to disease complexity and heterogeneity. Control of disease activity, the reduction of damage accrual and the patient’s quality of life should be considered as the main targets in SLE, and several new drugs are emerging to achieve these targets.
282
13 Jun 2023
Topic Review
The Sentinel Lymph Node in Treatment Planning
The sentinel lymph node is a surgical technique developed in oncological surgery to identify and analyze fewer lymph nodes than a conventional lymph node dissection in order to limit the morbidity and mortality of such an extensive procedure without compromising the patients’ outcomes. This concept seems to also be useful in radiation oncology that treats lymph node areas. This may help radiation oncologists to treat their patients more precisely by targeting more accurately pathological sites and sparing healthy tissues.
293
13 Jun 2023
Topic Review
Pathophysiology and Mortality with Peripheral Artery Disease
There are a number of devastating complications associated with peripheral artery disease, including limb amputations and acute limb ischemia. In coronary atherosclerosis, thrombosis is often precipitated by rupture or erosion of fibrous caps around atheromatous plaques, which leads to acute coronary syndrome.
404
13 Jun 2023
Topic Review
Focused Ultrasound for the Treatment of Brain Tumors
Focused ultrasound technology provides a method for overcoming the blood–brain and blood–tumor barriers through ultrasound frequency to transiently permeabilize or disrupt these barriers. Concomitant delivery of therapeutics has allowed for previously impermeable agents to reach the tumor microenvironment.
570
13 Jun 2023
Topic Review
Sleep–Wake Rhythm Influence Neurodevelopmental Disorders in Children
Development of the sleep–wake rhythm has a significant effect on the physical and mental development of children. The sleep–wake rhythm is controlled by aminergic neurons in the brainstem’s ascending reticular activating system, which is associated with synaptogenesis and the promotion of brain development. Before evaluating a sleep disorder in a child, it is of paramount importance to evaluate, as a prerequisite, whether ‘the parent or guardian has a stable sleep rhythm’ or whether ‘the parent or guardian pays attention to the adequate environment in which the child sleeps well at night’. The sleep rhythm of the child changes with that of his or her guardian.
395
13 Jun 2023
Topic Review
Drug-Eluting Contact Lens Technologies
Due to an ageing population and climate change, the number of ophthalmic patients will increase, overwhelming healthcare systems and likely leading to under-treatment of chronic eye diseases. Since drops are the mainstay of therapy, clinicians have long emphasised the unmet need for ocular drug delivery. Alternative methods, i.e., with better compliance, stability and longevity of drug delivery, would be preferred. Drug-loaded contact lenses are among the most promising and are a real step toward dropless ocular therapy, potentially leading to a transformation in clinical ophthalmic practice.
334
13 Jun 2023
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