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Topic Review
Biography
Topic Review
The Nervous System in Cancer Hallmarks
The nervous system communicates with the whole organism, regulating several physiological pathways. The modification of nerve activity could deregulate the state of cellular and tissue homeostasis which could drive cancer development.
366
11 Jul 2023
Topic Review
Hypothalamus and the Brainstem in Health and Obesity
The hypothalamus and brainstem are critical components of the homeostatic system that regulates appetite and energy balance. These key brain regions comprise of distinct neuronal populations and nuclei which exerts tremendous control over several facets of energy balance. Importantly, several of these neuronal populations exhibit both overlapping and also contrasting metabolic roles, thereby enabling the CNS to fine tune metabolic functions under physiological conditions.
363
11 Jul 2023
Topic Review
Metabolomic Profiling in Children with Celiac Disease
Celiac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors. Despite a growing understanding of the pathophysiological mechanisms of the disease, diagnosis is still often delayed and there are no effective biomarkers for early diagnosis. The only current treatment, a gluten-free diet (GFD), can alleviate symptoms and restore intestinal villi, but its cellular effects remain poorly understood. To gain a comprehensive understanding of CD’s progression, it is crucial to advance knowledge across various scientific disciplines and explore what transpires after disease onset. Metabolomics studies hold particular significance in unravelling the complexities of multifactorial and multisystemic disorders, where environmental factors play a significant role in disease manifestation and progression.
452
10 Jul 2023
Topic Review
Plant-Based Diets effects on Skin Diseases
A plant-based diet refers to a way of eating that primarily focuses on consuming foods derived from plants. This includes a wide variety of vegetables, fruits, beans, lentils, legumes, nuts, seeds, fungi, and whole grains. Animal products and processed foods are limited or avoided in this dietary approach. Plant-based diets have been found to have benefits for various conditions and diseases and specific plant-based functional foods can play a role in supporting skin health. One of the targets of this dietary pattern is the gut microbiota, the community of microorganisms residing in our digestive system. Improving the health of the gut microbiota may contribute to some of the positive effects observed on overall health, including the skin. By adopting a plant-based diet, individuals can provide their bodies with a rich array of nutrients, antioxidants, and fiber that are abundant in plant foods. These components can support overall health and may have a positive impact on the condition of the skin. However, it's important to note that individual results may vary, and maintaining a balanced diet, as well as considering other factors like skincare routines and overall lifestyle, is essential for optimal skin health.
436
10 Jul 2023
Topic Review
Patient-Derived Cancer Models and Next-Generation Living Biobanks
Biobanks provide a platform for innovative biomedical research. Recent scientific advances in cryopreservation have enabled the prospect of establishing “living biobanks” that store viable, functional tissue or replicable cell types for years to decades.
392
10 Jul 2023
Topic Review
Next-Generation Sequencing in Acute Myeloid Leukemia
Cytological approaches have long been used in the diagnosis, prognosis, and management of acute myeloid leukemia (AML) and myelodysplastic neoplasms. Technological advances in molecular biology, in particular next-generation sequencing (NGS), have made it possible to establish a molecular list of several gene mutations in AML and MDS, within a matter of days.
311
10 Jul 2023
Topic Review
The Multifold Etiologies of Limbal Stem Cell Deficiency
A brief overview of Limbal Stem Cell Deficiency including normal limbal stem cell physiology, pathophysiology, incidence and prevalence, clinical presentation, diagnosis and treatment. Included is a comprehensive list of several genetic, acquired, and immunologic etiologies of the disease.
215
10 Jul 2023
Topic Review
Ru-106 Brachytherapy
Ruthenium-106 brachytherapy emits beta radiation (Ru-106 gives off radiation in the form of high energy electrons called beta particles as it decays into rhodium-106 and then into palladium-106, which isn't radioactive) and is used for tumors up to 5 mm in height due to the limited range of radiation penetration, but in some centers, it is used to treat thicker tumors. Therefore, ruthenium is intended for the treatment of small and some medium-sized tumors.
422
10 Jul 2023
Topic Review
Phytochemicals and Parkinson’s Disease
Complementary therapies and phytonutrients derived from plant sources have been proposed as treatments for Parkinson’s disease. Numerous natural phytochemicals have emerged as therapeutically interesting compounds, drug entities, and phytochemicals for the treatment of inflammatory disorders. Additionally, numerous pharmacological studies have shown that phytochemicals are useful in treating neurodegenerative diseases (NDDs), depression, and dementia.
270
10 Jul 2023
Topic Review
Dietary Oncopharmacognosy
While diet and nutrition are modifiable risk factors for many chronic and infectious diseases, their role in cancer prevention and control remains under investigation. The lack of clarity of some diet–cancer relationships reflects the ongoing debate about the relative contribution of genetic factors, environmental exposures, and replicative errors in stem cell division as determinate drivers of cancer risk. In addition, dietary guidance has often been based upon research assuming that the effects of diet and nutrition on carcinogenesis would be uniform across populations and for various tumor types arising in a specific organ, i.e., that one size fits all.
313
10 Jul 2023
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