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Bergamot Oil: Botany, Production, Pharmacology
Bergamot essential oil (BEO) is the result of the mechanical manipulation (cold pressing) of the exocarp (flavedo) of the hesperidium of Citruslimon (L.) Osbeck Bergamot Group (synonym Citrus × bergamia Risso & Poit.), resulting in the bursting of the oil cavities embedded in the flavedo and the release of their contents. It is chemically dominated by monoterpene hydrocarbons (i.e., limonene), but with significant percentages of oxygenated monoterpenes (i.e., linalyl acetate) and of non-volatile oxygen heterocyclic compounds (i.e., bergapten). 
  • 2.3K
  • 13 Apr 2022
Topic Review
N-Acetylcysteine in Trichotillomania
N-acetylcysteine (NAC) (C5H9NO3S) is the acetylated precursor of the amino acid L-cysteine and functions as a glutamate modulator and antioxidant. It is widely known as a mucolytic, an antidote for acetaminophen overdose, and a nephroprotective agent for contrast administration. Trichotillomania (TTM), excoriation disorder, onychophagia, and onychotillomania are categorized as body focused repetitive behavior (BFRB) disorders, causing damage to the skin, hair, and/or nails with clinically significant psychosocial consequences.
  • 2.5K
  • 13 Jun 2022
Topic Review
Warfarin
Warfarin has been utilized for decades as an effective anticoagulant in patients with a history of strong risk factors for venous thromboembolism (VTE).
  • 2.5K
  • 05 May 2021
Topic Review
Compensatory Carry-Over Action Model (CCAM)
The Compensatory Carry-Over Action Model (CCAM) is innovative as most behavioral theories only model single activity. The CCAM, however, models different single activities—such as physical activity and nutrition —and how they change as a result of one another. Such lifestyle activities are assumed to be formed by higher-level goals, which can drive activity volitionally or unconsciously, and are rather unspecific. They become specific because of activities that are subjectively seen as leading to this goal. Each activity must be intended, pursued, and controlled. Specific resources ensure that individuals have the chance to translate their intentions into activity and that they resist distractors. Compensation and transfer (also called carry-over) operate between the different activities. If people devote all of their energy to one domain and believe that no resources remain for the other activity, compensation can help to attain goals. It is also possible that an individual successfully performs one activity, and existing or developing resources may be transferred to another activity.
  • 2.5K
  • 16 Dec 2020
Topic Review
Pharmaceutical Hydrates Analysis
This entry discusses a set of instrumental and computational methods that are used to characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been put on highlighting advantages as well as on presenting some limitations of the selected analytical approaches. This has been performed in order to facilitate the choice of an appropriate method depending on the type of the structural feature that is to be analyzed, that is, degree of hydration, crystal structure and dynamics, and (de)hydration kinetics. The presented techniques include X-ray diffraction (single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD)), spectroscopic (solid state nuclear magnetic resonance spectroscopy (ssNMR), Fourier-transformed infrared spectroscopy (FT-IR), Raman spectroscopy), thermal (differential scanning calorimetry (DSC), thermogravimetric analysis (TGA)), gravimetric (dynamic vapour sorption (DVS)), and computational (molecular mechanics (MM), Quantum Mechanics (QM), molecular dynamics (MD)) methods. Further, the successful applications of the presented methods in the studies of hydrated APIs as well as studies on the excipients’ influence on these processes have been described in many examples.
  • 2.5K
  • 19 Oct 2020
Topic Review
Carbohydrates, Deep and REM Sleep
Carbohydrate quantity was shown to affect sleep architecture, and especially N3 and REM sleep stages. Alterations in both quantity and quality of carbohydrate intake showed a significant effect on sleep initiation. Variations in carbohydrate quality significantly affected measures of sleep continuation. Further studies are needed to assess the effect of long-term carbohydrate interventions on sleep. 
  • 2.5K
  • 28 Sep 2021
Topic Review
Natural Compounds as Ferroptosis Inducers
Ferroptosis is classified as a non-canonical cell death mechanism. To date, several natural compounds have been discovered to induce ferroptosis in different cancer models.
  • 2.5K
  • 25 Feb 2021
Topic Review
Coping (Psychology)
In psychology, coping means to invest own conscious effort, to solve personal and interpersonal problems, in order to try to master, minimize or tolerate stress and conflict. The psychological coping mechanisms are commonly termed coping strategies or coping skills. The term coping generally refers to adaptive (constructive) coping strategies. That is strategies which reduce stress. In contrast, other coping strategies may be coined as maladaptive, if they increase stress. Maladaptive coping is therefore also described, when looking at the outcome, as non-coping. Furthermore, the term coping generally refers to reactive coping, i.e. the coping response which follows the stressor. This differs from proactive coping, in which a coping response aims to neutralize a future stressor. Subconscious or non-conscious strategies (e.g. defense mechanisms) are generally excluded from the area of coping. The effectiveness of the coping effort depends on the type of stress, the individual, and the circumstances. Coping responses are partly controlled by personality (habitual traits), but also partly by the social environment, particularly the nature of the stressful environment.
  • 2.5K
  • 17 Oct 2022
Topic Review
Instability
Research in instability has focused on the analysis of muscle activation. This systematic entry was to analyze the effects of unstable devices on speed, strength and muscle power measurements administered in the form of controlled trials to healthy individuals in adulthood. 
  • 2.5K
  • 27 Jan 2022
Topic Review
Dental Plaque
Dental plaque is a community of microorganisms found on the surface of teeth or other hard surfaces like dentures and embedded in a matrix of polymers of both host and bacterial origin.
  • 2.5K
  • 23 Sep 2021
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