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Topic Review
Various Antibiotic Interactions with Warfarin
Warfarin is the most widely used oral anticoagulant in North America and in the world. It has a long-established efficacy for the prevention of thromboembolic events in patients with cardiovascular risk factors such as chronic atrial fibrillation, prosthetic heart valves, venous thromboembolism, and coronary artery disease. 
  • 261
  • 09 Aug 2023
Topic Review
Radiotherapy in Breast Cancer-Induced Cardiovascular Toxicity
The number of patients diagnosed with breast cancer and cardiovascular disease is continuously rising. Treatment options for breast cancer have greatly evolved, but radiotherapy (RT) still has a key role in it. Despite many advances in RT techniques, cardiotoxicity is one of the most important side effects. 
  • 261
  • 09 Aug 2023
Topic Review
The Molecular Mechanisms of Anti-Obesity Medicinal Plants
Inflammation is a crucial factor in the development and progression of cardiovascular diseases (CVD). Cardiac remodeling in the presence of persistent inflammation leads to myocardial fibrosis and extracellular matrix changes, which reduce cardiac function, induce arrhythmias, and finally, cause heart failure. Medicinal plants and phytochemicals can cure and prevent obesity and inflammation. In comparison to conventional therapies, the synergistic effects of several phytochemicals boost their bioavailability and impact numerous cellular and molecular targets.
  • 211
  • 09 Aug 2023
Topic Review
Anticancer Activity of Napabucasin
Napabucasin (also known as BBI608) is a natural naphthoquinone originally identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo evidence demonstrated that napabucasin showed significant anticancer effects in various types of cancers. Napabucasin showed multiple anticancer activities, including proliferation inhibition, cell death induction, cell cycle arrest, metastasis suppression, drug resistance overcoming, and stemness inhibition, etc., which were documented in many benchworks.
  • 276
  • 09 Aug 2023
Topic Review
Cyclodextrins and Their Derivatives as Drug Stability Modifiers
Cyclodextrins (CDs) are versatile excipients that are widely used in the pharmaceutical industry as receptor molecules to form complexes with drugs. CDs are cyclic oligosaccharides composed of α-1,4-linked D-glucopyranoside subunits obtained through enzymatic starch degradation.
  • 215
  • 09 Aug 2023
Topic Review
Angiotensin Regulation of Vascular Homeostasis
Extensive research has been conducted to elucidate and substantiate the crucial role of the Renin-Angiotensin System (RAS) in the pathogenesis of hypertension, cardiovascular disorders, and renal diseases. Furthermore, the role of oxidative stress in maintaining vascular balance has been well established. It has been observed that many of the cellular effects induced by Angiotensin II (Ang II) are facilitated by reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
  • 193
  • 09 Aug 2023
Topic Review
SC and TE Treatment of Neurogenic Bladder Dysfunction
Tissue engineering (TE) is a rapidly evolving biomedical discipline that can play an important role in treating neurogenic bladder dysfunction and compensating for conventional options’ shortcomings. 
  • 293
  • 09 Aug 2023
Topic Review
Emerging Tumor Markers in Ovarian Cancer
Ovarian cancer (OC) is characterized by silent progression and late-stage diagnosis. It is critical to detect and accurately diagnose the disease early to improve survival rates. Tumor markers have emerged as valuable tools in the diagnosis and management of OC, offering non-invasive and cost-effective options for screening, monitoring, and prognosis.
  • 294
  • 09 Aug 2023
Topic Review
Therapies in Kidney Transplant Rejection
Despite significant advancements in immunosuppressive therapies, kidney transplant rejection continues to pose a substantial challenge, impacting the long-term survival of grafts. TCMR is diagnosed through histological examination of kidney biopsy samples, which reveal the infiltration of mononuclear cells into the allograft tissue. Corticosteroids serve as the primary treatment for TCMR, while severe or steroid-resistant cases may require T-cell-depleting agents, like Thymoglobulin. ABMR occurs due to the binding of antibodies to graft endothelial cells. The most common treatment for ABMR is plasmapheresis, although its efficacy is still a subject of debate. Other current therapies, such as intravenous immunoglobulins, anti-CD20 antibodies, complement inhibitors, and proteasome inhibitors, are also utilized to varying degrees, but their efficacy remains questionable. Management decisions for ABMR depend on the timing of the rejection episode and the presence of chronic changes. In managing both TCMR and ABMR, it is crucial to optimize immunosuppression and address adherence.
  • 288
  • 09 Aug 2023
Topic Review
Types of Breast Cancer Imaging
Cancer is an incurable disease based on unregulated cell division. Breast cancer is the most prevalent cancer in women worldwide, and early detection can lower death rates. Medical images can be used to find important information for locating and diagnosing breast cancer. The best information for identifying and diagnosing breast cancer comes from medical pictures.
  • 311
  • 09 Aug 2023
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