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Topic Review
Bisphenol A
Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as a protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few decades, studies exploring the mechanism of BPA activity revealed a direct link between BPA induced oxidative stress and disease pathogenesis. Antioxidants, reducing agents that prevent cellular oxidation reactions, can protect BPA toxicity. Although the important role of antioxidants in minimizing BPA stress has been demonstrated in many studies, a clear consensus on the associated mechanisms is needed, as well as the directives on their efficacy and safety. Herein, considering the distinct biochemical properties of BPA and antioxidants, we provide a framework for understanding how antioxidants alleviate BPA‐associated stress. We summarize the current knowledge on the biological function of enzymatic and non‐enzymatic antioxidants, and discuss their practical potential as BPA‐detoxifying agents.
  • 1.3K
  • 26 Oct 2020
Topic Review
Animal Models for DOHaD Research
Diverse animal models resembling human illnesses and pregnancy complications have been evaluated, such as hypertensive disorders of pregnancy , preeclampsia , chronic kidney disease , diabetes , polycystic ovary syndrome , maternal inflammation , maternal hypoxia , and sleep disorder .
  • 1.3K
  • 11 Jun 2021
Topic Review
Mechanism of Action of Carnosine
Carnosine is a natural endogenous molecule that has been extensively studied during the last years due to its promising beneficial effects for human health. It presents multimodal mechanisms of action, being able to exert antioxidant, anti-inflammatory and anti-aggregate activities, among others.
  • 1.3K
  • 11 May 2022
Topic Review
Properties of Pistacia lentiscus L.
Pistacia lentiscus L. (PlL) is a wild-growing shrub rich in terpenoids and polyphenols, the oil and extracts of which have been widely used against inflammation and infections, and as wound healing agents.
  • 1.3K
  • 11 May 2021
Topic Review
Tumor Temperature
The temperature of a solid tumor is often dissimilar to baseline body temperature and, compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of a tumor is dependent on metabolic activity and vascularization and can change due to tumor progression, treatment, or cancer type.
  • 1.3K
  • 13 Sep 2022
Topic Review
Chitosan in Lowering Cholesterol
Chitosan is one of the polymers containing acetyl glucosamine and glucosamine.
  • 1.3K
  • 28 Jan 2021
Topic Review
Integrative Body Psychotherapy
Integrative body psychotherapy (IBP) is a psychotherapy that recognizes and treats the somatic (physical), psychological/emotional, and spiritual nature of a human being. It is based on the premise that the body, mind, and spirit are not separate, but rather integrated parts of a whole person. Every experience has a physical, mental, emotional, and spiritual aspect, which manifests internally within the body and externally in relationship to others. IBP was first developed by Jack Lee Rosenberg starting in the late 1970s (see § History, below).
  • 1.3K
  • 14 Oct 2022
Topic Review
Anti-NLRP3 Inflammasome Natural Compounds
The nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome is a multimeric protein complex that recognizes various danger or stress signals from pathogens, the host, and the environment, leading to activation of caspase-1 and inducing inflammatory responses. This pro-inflammatory protein complex plays critical roles in pathogenesis of a wide range of diseases including neurodegenerative diseases, autoinflammatory diseases, and metabolic disorders. Therefore, intensive efforts have been devoted to understanding its activation mechanisms and to searching for its specific inhibitors. Approximately forty natural compounds with anti-NLRP3 inflammasome properties have been identified.
  • 1.3K
  • 26 Feb 2021
Topic Review
Food–Drug Interactions with Fruit Juices
Fruit juices contain a large number of phytochemicals that, in combination with certain drugs, can cause food–drug interactions that can be clinically significant and lead to adverse events. The mechanisms behind such interactions are in most cases related to phytochemical interference with the activity of cytochrome P450 metabolizing enzymes (CYPs) or drug transporters. Moreover, alterations in their activity can have a clinical relevance if systemic exposure to the drug is decreased or increased, meaning that the pharmacological drug effects are suboptimal, or the drug will cause toxicity. In general, the common pharmacokinetic parameters found to be altered in food–drug interactions regarding fruit juices are the area under the concentration–time curve, bioavailability, and maximum plasma concentration. In most cases, the results from the drug interaction studies with fruit juices provide only limited information due to the small number of subjects, which are also healthy volunteers. Moreover, drug interactions with fruit juices are challenging to predict due to the unknown amounts of the specific phytochemicals responsible for the interaction, as well as due to the inter-individual variability of drug metabolism, among others. Therefore, this work aims to raise awareness about possible pharmacological interactions with fruit juices. 
  • 1.3K
  • 29 May 2021
Topic Review
Treatment of Mental Disorders
Mental disorders are classified as a psychological condition marked primarily by sufficient disorganization of personality, mind, and emotions to seriously impair the normal psychological and often social functioning of the individual. Individuals diagnosed with certain mental disorders can be unable to function normally in society. Mental disorders may consist of several affective, behavioral, cognitive and perceptual components. The acknowledgement and understanding of mental health conditions has changed over time and across cultures. There are still variations in the definition, classification, and treatment of mental disorders.
  • 1.3K
  • 29 Nov 2022
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