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Topic Review
PD-1/PD-L1 antibody plus Anti-VEGF Inhibitors
A successful phase III trial for the combination of atezolizumab and bevacizumab (the IMbrave150 trial) in advanced hepatocellular carcinoma has recently been reported to show better survival benefit over sorafenib, standard of care for more than 12 years. This is a practice changing results and scientific rationale of this combination, PD-1/PD-L1 antibody plus anti-VEGF inhibitors is very important.
  • 1.3K
  • 18 Dec 2020
Topic Review
Effectiveness of Riboflavin on Migraine
Riboflavin (vitamin B2) is an essential water-soluble vitamin that helps prevent various medical conditions, such as sepsis, ischemia, and some cancers. Riboflavin’s biological effects, including antioxidant, anti-aging, anti-inflammatory, and anti-nociceptive effects, have been extensively studied. The pathophysiology of migraines is linked to oxidative stress with mitochondrial dysfunction, and neuroinflammation by the glial cell network.
  • 1.3K
  • 05 Aug 2021
Topic Review
Extraction, Isolation and Characterization of Bioactive Compounds
Diverse medicinal plants such as those from the genus Artemisia have been employed globally for centuries by individuals belonging to different cultures. Universally, Artemisia species have been used to remedy various maladies that range from simple fevers to malaria. 
  • 1.3K
  • 03 Dec 2021
Topic Review
Fungi-Derived β-Glucan on Tumor Progression
β-Glucans have been studied in animal species, from earthworms to humans. They form a heterogenous group of glucose polymers found in fungi, plants, bacteria, and seaweed. β-Glucans have slowly emerged as an important target for the recognition of pathogens. 
  • 1.3K
  • 23 Jun 2021
Topic Review
Anatomical-MRI Correlations in Hypertrophic Cardiomyopathy Adults and Children
Hypertrophic Cardiomyopathy (HCM) is the most frequent hereditary cardiovascular disease and the leading cause of sudden cardiac death in young individuals. Advancements in CMR imaging have allowed for earlier identification and more accurate prognosis of HCM. CMR has been validated as a technique with high sensitivity and specificity, very few contraindications, a low risk of side effects, and is overall a good tool to be employed in the management of HCM patients.
  • 1.3K
  • 11 Mar 2022
Topic Review
High-Density Lipoprotein
High-density lipoprotein (HDL), the smallest and most dense lipoprotein, is composed of a central hydrophobic non-polar lipid core, consisting of primarily triacylglycerols and cholesterol esters.
  • 1.3K
  • 29 Jan 2022
Topic Review
Biomarkers in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the leading causes of cancer-related death worldwide. HCC is highly heterogeneous, both within the tumor and among individuals, which is closely related to the HCC surveillance, diagnosis, prognosis, and treatment response. With the advances of next-generation sequencing, the genomic landscape of HCC has been identified which vastly improves our understanding of genetic and epigenetic changes and their interaction during HCC development.
  • 1.3K
  • 28 Sep 2022
Topic Review
Cannabis Sativa Revisited
Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. In detail, the entry shows the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression will be presented.
  • 1.3K
  • 04 Jul 2022
Topic Review
Aspartate in Cell Proliferation and Survival
Aspartate is a precursor for nucleotide synthesis and  is indispensable for cell proliferation. Moreover, the malate–aspartate shuttle plays a key role in redox balance, and a deficit in aspartate can lead to oxidative stress. It is now recognized that aspartate biosynthesis is largely governed by mitochondrial metabolism, including respiration and glutaminolysis in cancer cells. Therefore, under conditions that suppress mitochondrial metabolism, including mutations, hypoxia, or chemical inhibitors, aspartate can become a limiting factor for tumor growth and cancer cell survival.
  • 1.3K
  • 15 Jul 2022
Topic Review
Patent Foramen Ovale
A patent foramen ovale (PFO) is a commonly discovered potential opening between the right atrium (RA) and left atrium (LA) on routine echocardiographic surveillance in an otherwise asymptomatic infant or child. The importance of a PFO in some critical congenital heart defects (CHD), especially in neonates, is well recognized. 
  • 1.3K
  • 24 Apr 2022
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