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Topic Review
Natural products as Ras inhibitors
RAS genes encode signaling proteins, which, in mammalian cells, act as molecular switches regulating critical cellular processes as proliferation, growth, differentiation, survival, motility, and metabolism in response to specific stimuli. Deregulation of Ras functions has a high impact on human health: gain-of-function point mutations in RAS genes are found in some developmental disorders and thirty percent of all human cancers, including the deadliest. For this reason, the pathogenic Ras variants represent important clinical targets against which to develop novel, effective, and possibly selective pharmacological inhibitors.  Few druggable sites have been identified for wild type and some oncogenic Ras mutants, and few natural compounds able to attenuate Ras signaling have been identified so far. Natural products represent a virtually unlimited resource of structurally different compounds from which one could draw on for this purpose, given the improvements in the isolation and screening of active molecules from complex sources, which can now be exploited for the selection of potential Ras inhibitors from natural sources. 
  • 2.0K
  • 09 Dec 2020
Topic Review
IoT Wearable Sensors
 Interconnected sensing technology, such as IoT wearables and devices, present a promising solution for objective, reliable, and remote monitoring, assessment, and support through ambient assisted living.
  • 2.0K
  • 13 Apr 2021
Topic Review
UV Radiation in DNA Damage and Repair
Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma).
  • 2.0K
  • 27 Dec 2021
Topic Review
Tumor Spheroids and Organoids
Understanding and investigating tumors is carried out by researchers using a number of different methods. One exciting and promising area is 3D tumor models including spheriod and organoid models. They act in similar ways to tumors which means we can use them to gather important information. This ranges from the way tumors react through to how different treatments may work on tumors. Ultimately they may help guide us towards the types of drugs and therapies that could be used to treat tumors. This work gives an overview of these technologies, the types of 3D models available and how they can be used to improve treatments and their applications in personalized medicine. 
  • 2.0K
  • 26 Oct 2020
Topic Review
Breast Implant Illness
Breast implant illness refers to a combination of different symptoms related to breast implant surgery, including fatigue, brain fog, and arthralgias. This malaise occurs after cosmetic and reconstructive breast surgeries, although it has not been proven to be a disease. Complications associated with breast implants include breast pain, capsular contracture, infections, as well as other manifestations specific to breast reconstruction. 
  • 2.0K
  • 26 May 2022
Topic Review
Hericium Erinaceus for Depressive Disorder
Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. Hericium erinaceus, also known as Lion’s mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson’s disease, and Alzheimer’s disease. Bioactive compounds extracted from the mycelia and fruiting bodies of H. erinaceus have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects of H. erinaceus have not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression, H. erinaceus may be a potential alternative medicine for the treatment of depression. 
  • 2.0K
  • 30 Oct 2020
Topic Review
Dissociated Optic Nerve Fiber Layer
Dissociated optic nerve fiber layer (DONFL) appearance is characterized by dimpling of the fundus when observed after vitrectomy with the internal limiting membrane (ILM) peeling in macular diseases. However, the cause of DONFL remains largely unknown. Optical coherence tomography (OCT) findings have indicated that the nerve fiber layer (NFL) and ganglion cells are likely to have been damaged in patients with DONFL appearance. Since DONFL appearance occurs at a certain postoperative period, it is unlikely to be retinal damage directly caused by ILM peeling because apoptosis occurs at a certain period after tissue damage and/or injury. However, it may be due to ILM peeling-induced apoptosis in the retinal tissue. Anoikis is a type of apoptosis that occurs in anchorage-dependent cells upon detachment of those cells from the surrounding extracellular matrix (i.e., the loss of cell anchorage). The anoikis-related proteins βA3/A1 crystallin and E-cadherin are reportedly expressed in retinal ganglion cells. 
  • 2.0K
  • 05 Mar 2021
Topic Review
Natural Compounds and Autophagy Modulation
Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress responses. Dysregulation of cellular autophagy may lead to various diseases such as neurodegenerative disease, obesity, cardiovascular disease, diabetes, and malignancies. Recently, natural compounds have come to attention for being able to modulate the autophagy pathway in cancer prevention, although the prospective role of autophagy in cancer treatment is very complex and not yet clearly elucidated. Numerous synthetic chemicals have been identified that modulate autophagy and are favorable candidates for cancer treatment, but they have adverse side effects. Therefore, different phytochemicals, which include natural compounds and their derivatives, have attracted significant attention for use as autophagy modulators in cancer treatment with minimal side effects.
  • 2.0K
  • 30 Nov 2020
Topic Review
Silver in Ophthalmology
The use of silver preparations in medicine is becoming increasingly popular. 
  • 2.0K
  • 15 Apr 2021
Topic Review
Skin-Lightening Active Ingredients in Japan
Japanese pharmaceutical cosmetics, often referred to as quasi-drugs, contain skin-lightening active ingredients formulated to prevent sun-induced pigment spots and freckles. Their mechanisms of action include suppressing melanin production in melanocytes and promoting epidermal growth to eliminate melanin more rapidly. For example, arbutin and rucinol are representative skin-lightening active ingredients that inhibit melanin production, and disodium adenosine monophosphate and dexpanthenol are skin-lightening active ingredients that inhibit melanin accumulation in the epidermis. In contrast, oral administration of vitamin C and tranexamic acid in pharmaceutical products can lighten freckles and melasma, and these products are more effective than quasi-drugs. On the basis of their clinical effectiveness, skin-lightening active ingredients can be divided into four categories according to their effectiveness and adverse effects.
  • 2.0K
  • 08 Aug 2022
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