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Topic Review
Secondary Marine Metabolites
Secondary marine metabolites are defined as molecules with a molecular weight ranging between 100 to 1000 Da and, unlike primary marine metabolites, are often found to be unique to an organism or a specific taxonomic group of the marine source. Other than marine macroorganisms such as algae, sponges, or corals, specifically marine fungi and bacteria have shown to produce novel secondary metabolites with unique as well as diverse chemical structures that may hold the key for developing novel drugs or drug leads. Secondary marine metabolites have been found in both prokaryotic and eukaryotic microorganisms, with unicellular bacteria (e.g., Bacillus sp., Pseudomonas sp.), eukaryotic fungi (e.g., Penicillium sp., Aspergillus sp.), filamentous actinomyces (e.g., Streptomyces sp.), and terrestrial plants being the most frequently studied and versatile producers. A potential clarification why organisms produce a high assortment of bioactive secondary marine metabolites is that these molecules furnish producers with a specific advantage against competing organisms and, furthermore, act as an adaptation to ecological conditions.
  • 2.2K
  • 30 Sep 2020
Topic Review
Synthesis of Carbon Dots
There are many studies on the different synthesis methods of carbon dots. Each process aims to improve the synthesis strategy and optimize the reaction conditions so that the carbon dots are not only more cost-effective and eco-friendly, but also provide more excellent performance.
  • 2.2K
  • 08 Dec 2022
Topic Review
Micronutrients
Minerals and trace elements are micronutrients that are essential to the human body but present only in traceable amounts. Nonetheless, they exhibit well-defined biochemical functions. Deficiencies in these micronutrients are related to widespread human health problems such as diabetes, insulin resistance, improper immune function, bone health and brain development. The levels of trace elements may vary considerably among different populations, contingent on the composition of the diet and location. Local differences in selenium, zinc, copper, iron, chromium and iodine in the diet can affect physiological functions leading to malnourishment. Inadequate supply of a number of minerals and trace elements including iodine, selenium, zinc, calcium, chromium, cobalt, iron, boron and magnesium and in a few cases, excess of essential trace elements may lead to imbalances in glucose homeostasis and insulin resistance. Changes in these micronutrient levels in the serum and urine of subjects may signal towards metabolic changes, oxidative stress and other disease-related complications. Adequate supplement of the micronutrients may eliminate or protect against certain diseases such as heart disease.
  • 2.2K
  • 05 Nov 2020
Topic Review
Nutrition Composition and Bioactivity of Mangrove Fruit Extract
Mangroves are halophile plants with vital economic and ecological services. Some mangrove fruits are edible and contain treasury compounds with ethnomedicinal properties. The levels of primary metabolites such as carbohydrates, protein, and fat within mangrove fruit are acceptable for daily intake. The mangrove fruits are rich in phenolic compounds, limonoids, and their derivatives, as the compounds show antimicrobial, anticancer, and antioxidant activity.
  • 2.2K
  • 13 May 2022
Topic Review
Implant–Abutment Connections
Different implant–abutment connections have been developed to reduce mechanical and biological failure. The most frequent complications are loss of preload, screw loosening, abutment or implant fracture, deformations at the different interfaces, and bacterial microleakage.  To review the evidence indicating whether the implant–abutment connection type is significant regarding the following issues: (1) maintenance of the preload in static and dynamic in vitro studies; (2) assessment of possible deformations at the implant–abutment interfaces, after repeated application of the tightening torque; (3) evaluation of the sealing capability of different implant connections against microleakage. 
  • 2.2K
  • 08 Dec 2020
Topic Review
Rhinitis: Classification, Types, Pathophysiology
Rhinitis describes a pattern of symptoms as a result of nasal inflammation and/or dysfunction of the nasal mucosa. It is an umbrella entity that includes many different subtypes, several of which escape of complete characterization. Rhinitis is considered as a pathologic condition with considerable morbidity and financial burden on health care systems worldwide. Its economic impact is further emphasized by the fact that it represents a risk factor for other conditions such as sinusitis, asthma, learning disabilities, behavioral changes, and psychological impairment. Rhinitis may be associated with many etiologic triggers such as infections, immediate-type allergic responses, inhaled irritants, medications, hormonal disturbances, and neural system dysfunction. 
  • 2.2K
  • 01 Aug 2021
Topic Review
Assessment of Gastrointestinal Autonomic Dysfunction
The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson’s disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment.
  • 2.2K
  • 24 Apr 2021
Topic Review
Salvage Surgery
The representative surgical intervention for unresectable stage III/IV NSCLC is salvage surgery, which refers to surgical treatment for local residual/recurrent lesions after definitive non-surgical treatment. Surgical intervention is also used for an oligometastatic stage IV NSCLC. 
  • 2.1K
  • 29 Apr 2021
Topic Review
Apple Bioactive Compounds
Population studies have associated a diet high in fruits to lower incidence of cancer. Specifically, research shows that secondary plant metabolites known as phytochemicals, which are commonly found in fruits, have onco-preventive and chemo-protective effects. Apple is a commonly consumed fruit worldwide that is available all year round and is a rich source of phytochemicals. The health benefits of apples are thought to be mainly due to their phytochemical composition. Additionally, apple consumption is associated with lower incidence of some cancers based on animal and cell culture studies.
  • 2.1K
  • 30 Nov 2021
Topic Review
Botulinum Toxin Therapy for Oromandibular Dystonia
Botulinum neurotoxin injection is effective and safe, with few side effects in most cases when properly administered by an experienced clinician. The diagnosis and treatment of oromandibular dystonia require both neurological and dental or oral surgical knowledge and skills, and well-designed multicenter trials with a multidisciplinary team approach must be necessary to ensure accurate diagnosis and proper treatment. 
  • 2.1K
  • 23 Jun 2022
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