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Topic Review
Phosphaturic Mesenchymal Tumors
Phosphaturic mesenchymal tumors (PMT) are rare neoplasms, which can give rise to a multifaceted syndrome, otherwise called tumor-induced osteomalacia (TIO). Localizing these tumors is crucial to obtain a cure for the phosphate metabolism derangement, which is often the main cause leading the patient to seek medical help, because of invalidating physical and neuromuscular symptoms.
  • 318
  • 18 Aug 2023
Topic Review
Infectious Diseases Associated with the Use of IMT
In the last decades, immunotherapy (IMT) added Immune Checkpoint Inhibitors (ICI) as one of the most potent tools developed recently to improve traditional oncology treatment. ICI consists of using monoclonal antibodies to inhibit the immune checkpoints (IC)-ligand binding, and, consequently, the activation of the immune cells is conserved.
  • 334
  • 18 Aug 2023
Topic Review
Proteomic and Metabolomic Changes in Psoriasis
Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. 
  • 286
  • 17 Aug 2023
Topic Review
Patterns of ECMO-Related Acute Brain Injury
Extracorporeal membrane oxygenation (ECMO) is a frequently used mechanical cardiopulmonary support for rescuing critically ill patients for whom conventional medical therapies have failed. However, ECMO is associated with several complications, such as acute kidney injury, hemorrhage, thromboembolism, and acute brain injury (ABI). Among these, ABI, particularly intracranial hemorrhage (ICH) and infarction, is recognized as the primary cause of mortality during ECMO support.
  • 369
  • 17 Aug 2023
Topic Review
Targeted Therapy for EWS-FLI1 in Ewing Sarcoma
Ewing sarcoma (EwS) is a highly aggressive and metastatic cancer in children and adolescents. Canonical therapy mainly comprises the combination of intensive chemotherapy, radiation, and local surgery, which give rise to acute and chronic adverse effects. Drugs targeting EwS without side effects are in urgent demand. Genetically, EwS is characterized by chromosomal translocations with a low mutation burden. As a result, the chimeric protein EWS-ETS, mainly EWS-FLI1(85%), is critical for the malignancy of EwS. EWS-FLI1 directly binds to GGAA microsatellites in enhancers and promotors of the target genes and recruits multiple transcription factors or epigenetic regulators to reprogramme the epigenome.
  • 451
  • 17 Aug 2023
Topic Review
Sphingosine-1-Phosphate in Psychiatric Diseases
Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates both the immune response and the permeability of biological barriers. Notably, S1P-based drugs, such as fingolimod and ozanimod, have received approval for treating multiple sclerosis, an autoimmune disease of the central nervous system (CNS), and ulcerative colitis, an inflammatory condition of the colon, respectively.
  • 263
  • 17 Aug 2023
Topic Review
CBT-E for Age-Transition Eating Disorders
Many people with eating disorders transit from child and adolescent to adult clinical services. This transition often creates a gap in regular treatment and interruption of the therapeutic relationship with negative consequences. The change in the nature of the treatment often disorients patients and their parents. All-age eating disorder clinical services is a potential solution to address these challenges and enhanced cognitive behaviour therapy (CBT-E) is one of the major candidates among the individual psychological treatments to be the treatment of choice in all-age eating disorder services.
  • 412
  • 17 Aug 2023
Topic Review
Artificial Intelligence in Breast Surgery
Breast reconstruction is a pivotal part of the recuperation process following a mastectomy and aims to restore both the physical aesthetic and emotional well-being of breast cancer survivors. In recent years, artificial intelligence (AI) has emerged as a revolutionary technology across numerous medical disciplines. The role of AI in the domain of breast reconstruction is explored. 
  • 385
  • 17 Aug 2023
Topic Review
Omega-3 Fatty Acids in Arterial Hypertension
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), including alpha-linolenic acid (ALA) and its derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are “essential” fatty acids mainly obtained from diet sources comprising plant oils, marine blue fish, and commercially available fish oil supplements.
  • 292
  • 17 Aug 2023
Topic Review
Perivascular Adipose Tissue Oxidative Stress in Obesity
Perivascular adipose tissue (PVAT) adheres to most systemic blood vessels in the body. Healthy PVAT exerts anticontractile effects on blood vessels and further protects against cardiovascular and metabolic diseases. Healthy PVAT regulates vascular homeostasis via secreting an array of adipokine, hormones, and growth factors. Normally, homeostatic reactive oxygen species (ROS) in PVAT act as secondary messengers in various signalling pathways and contribute to vascular tone regulation.
  • 413
  • 17 Aug 2023
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