Topic Review
Scopophobia
Scopophobia, scoptophobia, or ophthalmophobia is an anxiety disorder characterized by a morbid fear of being seen in public or stared at by others. Similar phobias include erythrophobia, the fear of blushing, and an epileptic's fear of being looked at, which may itself precipitate such an attack. Scopophobia is also commonly associated with schizophrenia and other psychiatric disorders. Often scopophobia will result in symptoms common with other anxiety disorders. Scopophobia is unique among phobias in that the fear of being looked at is considered both a social phobia and a specific phobia.
  • 2.7K
  • 10 Oct 2022
Topic Review
L-Carnitine in Mitochondria
Mitochondria control cellular fate by various mechanisms and are key drivers of cellular metabolism. Although the main function of mitochondria is energy production, they are also involved in cellular detoxification, cellular stabilization, as well as control of ketogenesis and glucogenesis. Conditions like neurodegenerative disease, insulin resistance, endocrine imbalances, liver and kidney disease are intimately linked to metabolic disorders or inflexibility and to mitochondrial dysfunction. Mitochondrial dysfunction due to a relative lack of micronutrients and substrates is implicated in the development of many chronic diseases. l-carnitine is a vital molecule that is found in all living cells. It is a quaternary amine (3-hydroxy-4-N-trimethylaminobutyrate) whose main function in mammalian cells is the transfer of long chain fatty acids across the inner mitochondrial membrane for β- oxidation and generation of ATP energy. 
  • 2.7K
  • 11 Mar 2022
Topic Review
Intraretinal Fluid Pattern Characterization
The accumulation of fluids in the retinal layers is one of the main causes of blindness in developed countries. The main strategy for its study and diagnosis is through the use of Optical Coherence Tomography (OCT) images. This allows experts to observe the layers of the retina in a cross-sectional view. Commonly, for the analysis of these accumulations by means of computer diagnostic support systems, precise segmentation strategies are employed.
  • 2.7K
  • 22 Apr 2021
Topic Review
Manual Muscle Testing for Post-Stroke Upper Extremity Assessment
The Manual Muscle Testing (MMT) scoring system is an assessment tool used by rehabilitation physicians or physiatrists, physiotherapists, neurologists, and other clinicians who deal with the individuals’ functional status. The most frequently used approach is the use of MMT to assess the grade of muscle weakness in different pathologies.
  • 2.7K
  • 16 Jun 2022
Topic Review
Transgender Hormone Therapy (Male-to-female)
Transgender hormone therapy of the male-to-female (MTF) type, also known as transfeminine hormone therapy, is hormone therapy and sex reassignment therapy to change the secondary sexual characteristics of transgender people from masculine or androgynous to feminine. It is one of two types of transgender hormone therapy (the other being female-to-male) and is predominantly used to treat transgender women and other transfeminine individuals. Some intersex people also take this form of therapy, according to their personal needs and preferences. The purpose of the therapy is to cause the development of the secondary sex characteristics of the desired sex, such as breasts and a feminine pattern of hair, fat, and muscle distribution. It cannot undo many of the changes produced by naturally occurring puberty, which may necessitate surgery and other treatments to reverse (see below). The medications used for the MTF therapy include estrogens, antiandrogens, progestogens, and gonadotropin-releasing hormone modulators (GnRH modulators). While the therapy cannot undo the effects of a person's first puberty, developing secondary sex characteristics associated with a different gender has been shown to relieve some or all of the distress and discomfort associated with gender dysphoria, and can help the person to "pass" or be seen as the gender they identify with. Introducing exogenous hormones into the body impacts it at every level and many patients report changes in energy levels, mood, appetite, etc. The goal of the therapy is to provide patients with a more satisfying body that is more congruent with their gender identity.
  • 2.6K
  • 06 Oct 2022
Topic Review
Existential Suffering in Palliative Care
Existential suffering refers to one's angst due to a perceived loss of meaning, hope, relationships, and a sense of self in thinking about death and dying. Quality palliative care not only takes care of patients’ physical and existential suffering but also fills their last days with opportunities for redemption, spiritual growth, and reconciliation. We propose a holistic approach as illustrated by the healing wheel, involving health care providers, the community, patients, and a Higher Power.
  • 2.6K
  • 29 Sep 2021
Topic Review
Glutamatergic System in Depression
Major depressive disorder (MDD) is a heterogeneous neuropsychological disorder characterized by a combination of symptoms that negatively impact the productivity and well-being of inflicted patients, including impairments in cognition, emotional regulation, memory, motor function, motivation, and possible suicidal ideation. Glutamate is the major excitatory neurotransmitter in the central nervous system. It plays an important role in several physiological functions.
  • 2.6K
  • 11 May 2022
Topic Review
Plants as anti-inflammatory drugs
Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective.
  • 2.6K
  • 25 Aug 2020
Topic Review
Sustainable Employability
Sustainable employability (SE) generally refers to employees’ capacities to function in work and on the labor market throughout their working lives. However, several definitions have been forwarded in the scientific literature that differ in nuanced ways. A recent overview of existing definitions is provided by Fleuren, de Grip, Jansen, Kant, and Zijlstra (2020).[1]
  • 2.6K
  • 29 Oct 2020
Topic Review
Bovine Colostrum in the Treatment of Cancer
Bovine colostrum (BC) has attracted the interest of numerous researchers investigating its anti-cancer potential in humans. Dressings loaded with BC are beneficial in treating chronic wounds and diabetic foot ulcers. Lactoferrin, a glycoprotein with potent anti-oxidant, anti-inflammatory, anti-cancer, and anti-microbial effects, is abundant in BC. The BC pills successfully promote the regression of low-grade cervical intraepithelial neoplasia when administered intravaginally. The biological, genetic, and molecular mechanisms driving BC remain to be determined. Oral BC supplements are generally well-tolerated, but some flatulence and nausea may happen. 
  • 2.6K
  • 21 Dec 2022
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