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Topic Review
Tetrodotoxin
Tetrodotoxin (TTX) is a crystalline, weakly basic, colorless organic substance and is one of the most potent marine toxins known. Although TTX was first isolated from pufferfish, it has been found in numerous other marine organisms and a few terrestrial species. 
  • 3.4K
  • 17 Jan 2022
Topic Review
Moral Insanity
Moral insanity referred to a type of mental disorder consisting of abnormal emotions and behaviours in the apparent absence of intellectual impairments, delusions, or hallucinations. It was an accepted diagnosis in Europe and America through the second half of the 19th century. The physician James Cowles Prichard first used the phrase to describe a mental disorder in 1835 in his Treatise on insanity and other disorders affecting the mind. He defined moral insanity as: "madness consisting in a morbid perversion of the natural feelings, affections, inclinations, temper, habits, moral dispositions, and natural impulses, without any remarkable disorder or defect of the interest or knowing and reasoning faculties, and particularly without any insane illusion or hallucinations." The concept of moral insanity was indebted to the work of physician Philippe Pinel, which was acknowledged by Prichard. Pinel had described mental diseases of only partial, affective, insanity. His concept Manie sans délire (Latin – mania sine delirio; French – folie raisonnante or folie lucide raisonnante, monomanie affective; German – Moralisches Irresein) referred to insanity without delusion. That is, the sufferer was thought to be mad in one area only and thus the personality of the individual might be distorted but his or her intellectual faculties were unimpaired. The term 'moral', at that time and taken originally from French, could mean emotional rather than necessarily referring to ethics.
  • 3.4K
  • 28 Oct 2022
Topic Review
Botulinum Neurotoxin Injection Targeting the Platysma Muscle
The platysma muscle is a thin superficial muscle that covers the entire neck and lower part of the face. The platysma muscle is the primary target muscle for botulinum neurotoxin injection therapy aimed at treating platysmal band and lower facial lifting. In the procedure of botulinum neurotoxin injection therapy, a lack of knowledge of the anatomy of the platysma muscle and the properties of botulinum neurotoxin can lead to side effects such as dysphagia, dysphonia, and weakness of the neck muscles. Anatomically safe injection sites have been proposed for the platysma muscle, and the appropriate injection technique has been reviewed.
  • 3.4K
  • 20 Dec 2022
Topic Review
Salvia divinorum
Salvia divinorum Epling and Játiva is a psychoactive Mexican mint used for centuries by Mazatec Indian shamans or curanderos of north-eastern Oaxaca, Mexico, for divinatory and religious purposes and physical healing.
  • 3.4K
  • 18 Mar 2021
Topic Review
Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide. Most patients are diagnosed with advanced disease, limiting their options for treatment. While current treatments are adequate for lower staged disease, available systemic treatments are limited, with marginal benefit at best. The below section reviews the incidence, prevalence, healthcare associated cost, and etiologies of HCC. In addition, an overview of the classification, treatment algorithm, and treatment modalities are provided.
  • 3.4K
  • 07 Jan 2021
Topic Review
Compartmental Models in Epidemiology
Compartmental models are a very general modelling technique. They are often applied to the mathematical modelling of infectious diseases. The population is assigned to compartments with labels – for example, S, I, or R, (Susceptible, Infectious, or Recovered). People may progress between compartments. The order of the labels usually shows the flow patterns between the compartments; for example SEIS means susceptible, exposed, infectious, then susceptible again. The origin of such models is the early 20th century, with important works being that of Ross in 1916, Ross and Hudson in 1917, Kermack and McKendrick in 1927 and Kendall in 1956 The models are most often run with ordinary differential equations (which are deterministic), but can also be used with a stochastic (random) framework, which is more realistic but much more complicated to analyze. Models try to predict things such as how a disease spreads, or the total number infected, or the duration of an epidemic, and to estimate various epidemiological parameters such as the reproductive number. Such models can show how different public health interventions may affect the outcome of the epidemic, e.g., what the most efficient technique is for issuing a limited number of vaccines in a given population.
  • 3.4K
  • 02 Dec 2022
Topic Review
Morphea
Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients' quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects.
  • 3.4K
  • 12 Aug 2021
Topic Review
Activity of Natural Carboxylic Acids
Natural carboxylic acids described in this paper are plant-derived compounds having biological activity. The aim of this review is to summarize and evaluate the physicochemical properties of selected compounds naturally occurring in plants, their potential of microbiological  and anticancer activity. In order to create targeted modifications of the structure enhancing its activity, it is; therefore, necessary to thoroughly understand the mechanisms of action of a given molecule under systemic conditions.
  • 3.4K
  • 03 Dec 2020
Topic Review
Generalizing the Local Average Treatment Effect
The local average treatment effect (LATE), also known as the complier average causal effect (CACE), refers to the treatment effect among compliers. The LATE may not be of the same value as the average treatment effect (ATE), so extrapolating the LATE directly should be done cautiously. In addition, the LATE retrieved from an experiment may not immediately be externally valid, especially when there is a case for treatment effect heterogeneity (i.e. the treatment effect varies across individuals).  However, generalizing the LATE through reweighting can be attempted, given certain key assumptions.
  • 3.3K
  • 30 Oct 2022
Topic Review
Factors Affecting Hair Health
Hair health is associated with personal distress and psychological well-being. Even though hair loss (alopecia) does not affect humans’ biological health, it affects an individual’s social well-being. So, treatment for hair problems and improving hair health are obligatory. 
  • 3.3K
  • 07 Feb 2023
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