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Topic Review
Fascin-1 in Cancer Cell Metastasis
As metastasis is responsible for most cancer-related deaths, understanding the cellular and molecular events that lead to cancer cell migration and invasion will certainly provide insights into novel anti-metastatic therapeutic targets. Fascin-1 is an actin-bundling protein fundamental to all physiological or pathological processes that require cell migration. It is responsible for cross-linking actin microfilaments during the formation of actin-rich cellular structures at the leading edge of migrating cells such as filopodia, lamellipodia and invadopodia. While most epithelial tissues express low levels of Fascin-1, it is dramatically elevated in the majority of cancers and its expression has been associated with more aggressive disease and decreased overall survival. Hence, it has been proposed as a potential anti-cancer target.
  • 181
  • 21 Jul 2023
Topic Review
Fatty Acid Metabolism Reprogramming in Prostate Cancer
Fatty acids metabolism is rewired significantly in prostate cancer (PCa). Although PCa can be treated with hormone therapy, after prolonged treatment, castration-resistant prostate cancer (CRPC) can develop and can lead to increased mortality. Both whole-body fatty acid (FA) metabolism in PCa patients and cellular FA metabolism play important roles in PCa origination and development. FA metabolism may provide potential candidate targets for the treatment or diagnosis of PCa.
  • 545
  • 20 Sep 2022
Topic Review
Female Germ Cell Development
In the present era, infertility is one of the major issues which restricts many couples to have their own children. Infertility is the inability to achieve a clinical pregnancy after regular unprotected sexual intercourse for the period of one year or more. Various factors including defective male or female germ cell development, unhealthy and improper lifestyles, diseases like cancer and associated chemo-or-radiation therapies, congenital disorders, etc., may be responsible for infertility. Therefore, it is highly important to understand the basic concepts of germ cell development including primordial germ cell (PGC) formation, specification, migration, entry to genital ridges and their molecular mechanisms, activated pathways, paracrine and autocrine signaling, along with possible alteration which can hamper germ cell development and can cause adversities like cancer progression and infertility. Knowing all these aspects in a proper way can be very much helpful in improving our understanding about gametogenesis and finding possible ways to cure related disorders. 
  • 1.2K
  • 10 Jun 2021
Topic Review
Ferroptosis and Its Role in Chronic Diseases
Ferroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of cell death. The course of ferroptosis can be accurately regulated by the metabolism of iron, lipids, amino acids, and various signal pathways. 
  • 814
  • 12 Jul 2022
Topic Review
Ferroptosis and Pre-Eclampsia Therapy
Iron is essential for cell survival, and iron deficiency is a known risk factor for many reproductive diseases. Paradoxically, such disorders are also more common in cases of iron overload. Here, the researchers evaluated the role of ferroptosis in women’s health, particularly focusing on pre-eclampsia (PE). PE is a multisystem disorder and is one of the leading causes of maternal and perinatal morbidity and mortality, especially when the condition is of early onset. Nevertheless, the exact etiological mechanism of PE remains unclear. Interestingly, ferroptosis, as a regulated iron-dependent cell death pathway, involves a lethal accumulation of lipid peroxides and shares some characteristics with PE pathophysiology. 
  • 401
  • 12 Jul 2022
Topic Review
Ferroptosis in Brief
Ferroptosis is a newly discovered, iron-dependent form of programmed cell death characterized by the lethal accumulation of lipid peroxides within cell membranes. This process, distinct from apoptosis or necrosis, is driven by disruptions in cellular iron homeostasis and subsequent oxidative damage. Ferroptosis plays a pivotal role in various physiological processes and diseases, including cancer, neurodegenerative disorders, and ischemic injuries. Understanding the mechanisms and regulation of ferroptosis holds promise for the development of novel therapeutic strategies, making it a burgeoning field of research in cell biology and medicine with potential applications across a wide range of health-related challenges.
  • 250
  • 18 Sep 2023
Topic Review
Ferroptosis in Cancers and Leukemia
Ferroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Grow- ing evidence suggests ferroptosis induction as a novel anti-cancer modality that could potentially overcome therapy resistance in cancers. The molecular mechanisms involved in the regulation of ferroptosis are complex and highly dependent on context. Therefore, a comprehensive understanding of its execution and protection machinery in each tumor type is necessary for the implementation of this unique cell death mode to target individual cancers. 
  • 475
  • 04 May 2023
Topic Review
Ferroptosis in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease with steatosis as the main pathological feature, including simple fatty liver degeneration, non-alcoholic steatohepatitis (NASH). It may develop into cirrhosis and liver cancer. NAFLD is the most common chronic liver disease in the world today, and its incidence in the Euro-American region has reached more than 20%.
  • 522
  • 20 Dec 2021
Topic Review
Ferroptosis Meets Cell-Cell Contacts
Ferroptosis is a regulated form of cell death characterized by iron-dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues. Deregulated ferroptosis has been linked to human diseases, such as neurodegenerative diseases, cardio-vascular disorders, and cancer. Along these lines, ferroptosis is a promising pathway to overcome therapy resistance of cancer cells. It is therefore of utmost importance to understand the cellular signalling pathways and the molecular mechanisms underlying ferroptosis regulation including context-specific effects mediated by the neighbouring cells through cell-cell contacts. 
  • 261
  • 04 May 2023
Topic Review
Ferroptosis Modulation as Therapeutic Target for Glioblastoma Treatment
Glioblastoma multiforme is a lethal disease and represents the most common and severe type of glioma. Drug resistance and the evasion of cell death are the main characteristics of its malignancy, leading to a high percentage of disease recurrence and the patients’ low survival rate. Exploiting the modulation of cell death mechanisms could be an important strategy to prevent tumor development and reverse the high mortality and morbidity rates in glioblastoma patients. Ferroptosis is a recently described type of cell death, which is characterized by iron accumulation, high levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, and deficiency in lipid peroxidation repair. Several studies have demonstrated that ferroptosis has a potential role in cancer treatment and could be a promising approach for glioblastoma patients.
  • 412
  • 08 Jul 2022
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