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Topic Review
Biomass Wastes Produce Carbon Dots
The fluorescent carbon dot is a novel type of carbon nanomaterial. In comparison with semiconductor quantum dots and fluorescence organic agents, it possesses significant advantages such as excellent photostability and biocompatibility, low cytotoxicity and easy surface functionalization, which endow it a wide application prospect in fields of bioimaging, chemical sensing, environmental monitoring, disease diagnosis and photocatalysis as well. Biomass waste is a good choice for the production of carbon dots owing to its abundance, wide availability, eco-friendly nature and a source of low cost renewable raw materials such as cellulose, hemicellulose, lignin, carbohydrates and proteins, etc.
  • 2.3K
  • 18 Feb 2021
Topic Review
Biomass-Based Furan Compounds
Bio-based furanic oxygenates represent a well-known class of lignocellulosic biomass-derived platform molecules. In the presence of H2 and different nitrogen sources, these versatile building blocks can be transformed into valuable amine compounds via reductive amination or hydrogen-borrowing amination mechanisms, yet they still face many challenges due to the co-existence of many side-reactions, such as direct hydrogenation, polymerization and cyclization. Hence, catalysts with specific structures and functions are required to achieve satisfactory yields of target amines.
  • 422
  • 18 Apr 2023
Topic Review
Biomass-Derived 2,3-Butanediol and Its Application in Biofuels Production
2,3-butanediol (2,3-BDO) is an important biomass-derived platform chemical with various applications. The biological conversion of renewable carbon sources with bacteria or yeasts is a sustainable way to produce 2,3-BDO. Various carbon sources including glucose, glycerol, molasses and lignocellulose hydrolysate have been used for 2,3-BDO production, and the 2,3-BDO concentration in the fermentation broth can be higher than 150 g/L by optimizing the operating parameters with fed-batch operations. Various derivatives can be produced from 2,3-BDO, including isobutyraldehyde, 1,3-butadiene, methyl ethyl ketone (MEK), diacetyl, etc.; among these, there is a large market demand for MEK and 1,3-butadiene each year. Some of the derivatives can be used as fuel additives or to produce biofuels. Generally, there are three ways to produce hydrocarbon fuels from 2,3-BDO, which are via the steps of dehydration, carbon chain extension, and hydrogenation (or hydrodeoxygenation), with MEK or 1,3-butadiene as the intermediates. C8–C16 alkanes can be produced by these routes, which can be potentially used as bio-jet fuels.
  • 307
  • 24 Aug 2023
Topic Review
Biomass-Derived Furfurals, Furanic Biofuels
The concomitant hydrolysis and dehydration of biomass-derived cellulose and hemicellulose to furfural (FUR) and 5-(hydroxymethyl)furfural (HMF) under acid catalysis allows a dramatic reduction in the oxygen content of the parent sugar molecules with a 100% carbon economy. However, most applications of FUR or HMF necessitate synthetic modifications. Catalytic hydrogenation and hydrogenolysis have been recognized as efficient strategies for the selective deoxygenation and energy densification of biomass-derived furfurals generating water as the sole byproduct.
  • 581
  • 08 Oct 2021
Topic Review
Biomaterial-Mediated Gene Therapy in Cartilage Repair
Articular cartilage defects caused by various reasons are relatively common in clinical practice, but the lack of efficient therapeutic methods remains a substantial challenge due to limitations in the chondrocytes’ repair abilities. In the search for scientific cartilage repair methods, gene therapy appears to be more effective and promising, especially with acellular biomaterial-assisted procedures. Biomaterial-mediated gene therapy has mainly been divided into non-viral vector and viral vector strategies, where the controlled delivery of gene vectors is contained using biocompatible materials. Genetic therapy, on the other hand, aims to transfer exogenous genes into target cells in order to induce endogenous gene expression to complete treatment. It has been extensively used in cartilage repair. Genetic editing is used to promote stable expressions of various growth factors for osteochondral regeneration. Meanwhile, biomaterial mediation could further localize the effect of genetic therapy by providing a scaffold to limit the genetically modified cells and vectors to within the targeted region; this increases the precision of the treatment, and makes it an ideal approach for treating osteochondral injuries.
  • 314
  • 14 Oct 2022
Topic Review
Biomaterials and Their Potentialities as Additives in Bitumen
A lot of research is ongoing to improve bitumen’s properties due to its use as a binder in road paving processes. Over the years, the most common method to improve bitumen’s properties has been with the use of additives. The major drawback in the use of these additives is the fact that they are substances of strong chemical nature which are either too acidic, too basic or emit toxic fumes and volatile organic compounds into the environment. In the long run, these chemicals are also toxic to the road pavement personnel that carry out the day to day industrial and paving operations. This led researchers to the initiative of synthesizing and applying biomaterials to be used as additives for bitumen. In this light, several studies have investigated the use of substances such as bio-oils, natural waxes, gum, polysaccharides and natural rubber. 
  • 612
  • 13 Jan 2023
Topic Review
Biomaterials as Haemostatic Agents in Cardiovascular Surgery
Intraoperative haemostasis is of paramount importance in the practice of cardiovascular surgery. Topical haemostatic methods have advanced significantly and today we deal with various haemostatic agents with different properties and different mechanisms of action. The particularity of coagulation mechanisms after extracorporeal circulation, has encouraged the introduction of new types of topic agents to achieve haemostasis, where conventional methods prove their limits. These products have an important role in cardiac, as well as in vascular, surgery, mainly in major vascular procedures, like aortic dissections and aortic aneurysms.
  • 371
  • 31 Mar 2022
Topic Review
Biomaterials for Drugs Nose–Brain Transport
Recently, the intranasal route has emerged as a promising administration site for central nervous system therapeutics since it provides a direct connection to the central nervous system, avoiding the passage through the blood–brain barrier, consequently increasing drug cerebral bioavailability.
  • 584
  • 13 Apr 2021
Topic Review
Biomaterials for Ophthalmic Applications
Ophthalmology is the branch of medicine that deals with diseases of the eye, the organ responsible for vision, and its attachments. Biomaterials can be made with different types of materials and can replace or improve a function or an organ, specifically the eye in the case of ophthalmic biomaterials. Biomaterials are substances that interact with biological systems for a medical purpose, either as a therapeutic (treat, augment, repair, or replace a tissue function of the body) or a diagnostic agent, and have continued to improve over the years, leading to the creation of new biomaterials.
  • 1.9K
  • 22 Jun 2022
Topic Review
Biomaterials in 3D Cell Culture
The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. 
  • 645
  • 16 Apr 2021
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