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Topic Review
Polymer-Drug Conjugate in Breast and Lung Cancer
Cancer is a chronic disease that is responsible for the high death rate, globally. The administration of anticancer drugs is one crucial approach that is employed for the treatment of cancer, although its therapeutic status is not presently satisfactory. The anticancer drugs are limited pharmacologically, resulting from the serious side effects, which could be life-threatening. Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. They transport therapeutic agents to the target cell/tissue. 
  • 528
  • 29 Mar 2022
Topic Review
Mesenchymal Stem Cell-Based Regenerative Medicine
In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules, they are not detected by immune surveillance and do not lead to graft rejection after transplantation. These properties make them competent biomedical candidates, especially in tissue engineering.
  • 600
  • 29 Mar 2022
Topic Review
ATT Triplex and DNA
Due to the involvement of DNA:RNA hybrids and triplex helices in many essential functions in cells, this entry’s main aim is to detect benzothiazole based moieties with selective binding or spectroscopic response to these nucleic structures compared to regular (non-hybrid) DNA and RNA duplexes and single-stranded forms.
  • 673
  • 29 Mar 2022
Topic Review
Dental Implantology
Dental implants are most similar to natural teeth in their mastication and aesthetics; they are also biocompatible and require biocompatibility, masticatory feature, and aesthetic follow-up. The American Association of Oral and Maxillofacial Surgeons estimated that two million implants are placed per year worldwide. The longevity of the population and the demand for cosmetic dentistry have led to their increasing use.
  • 557
  • 29 Mar 2022
Topic Review
Silica-Based Stimuli-Responsive Systems
Silica nanoparticles are safe vehicles for antitumor molecules due to their stability in physiological medium, high surface area and easy functionalization, and good biocompatibility. Silica surface can be engineered with specific organic moieties for the development of stimuli-responsive systems (SRSs), that is, delivery nanostructures that release their cargo under the action of a specific stimulus. When used as drug carriers, these stimuli-responsive nanoparticles are good candidates for strong therapeutic activity with no toxicity effects.
  • 375
  • 29 Mar 2022
Topic Review
Nymphaea hybrid
Nymphaea hybrid is a perennial aquatic herb of Nymphaea in Nymphaeaceae. It is fragrant, colourful and indispensable as the main plant in features of water purification. Here includes the extraction from Nymphaea hybrid, isolation, structural characterization and evaluation of antioxidant capacity in vitro. 
  • 587
  • 29 Mar 2022
Topic Review
Amazonian Bacuri (Platonia insignis Mart.)
Bacuri (Platonia insignis Mart) is a species from the Clusiaceae genus. Its fruit pulp is commonly used in South America in several food products, such as beverages, ice cream and candies. Only the pulp of the fruit is used, and the peels and seeds are considered waste from these industries.
  • 1.5K
  • 29 Mar 2022
Topic Review
Nanomaterial Probes for Nuclear Imaging
Nuclear imaging is a powerful non-invasive imaging technique that is rapidly developing in medical theranostics. Nuclear imaging requires radiolabeling isotopes for non-invasive imaging through the radioactive decay emission of the radionuclide. Nuclear imaging probes, commonly known as radiotracers, are radioisotope-labeled small molecules. Nanomaterials have shown potential as nuclear imaging probes for theranostic applications. By modifying the surface of nanomaterials, multifunctional radio-labeled nanomaterials can be obtained for in vivo biodistribution and targeting in initial animal imaging studies. Various surface modification strategies have been developed, and targeting moieties have been attached to the nanomaterials to render biocompatibility and enable specific targeting. Through integration of complementary imaging probes to a single nanoparticulate, multimodal molecular imaging can be performed as images with high sensitivity, resolution, and specificity. 
  • 689
  • 29 Mar 2022
Topic Review
Protein Binding of Benzofuran Derivatives
Benzofuran derivatives are synthetic compounds that are finding an increasing interest in the scientific community not only as building blocks for the realization of new materials, but also as potential drugs thanks to their ability to interact with nucleic acids, interfere with the amyloid peptide aggregation and cancer cell cycle. However, their ability to interact with proteins is a theme still in need of investigation for the therapeutic importance that benzofurans could have in the modulation of protein-driven processes, and for the possibility of making use of serum albumins as benzofurans delivery systems.
  • 573
  • 29 Mar 2022
Topic Review
Self-Healing Hydrogels for Biomedical Applications
Self-healing is the remarkable ability of living organisms to repair their own damage by themselves. Inspired from nature, the great challenge for researchers is to create and develop polymers and composites with high potential for self-healing, offering alternatives to the current options and moving toward materials with extended service lifetime for various applications. Most of recent publications in this area concern innovative (bio)materials with excellent healing performance, such as ionomers, semiconductors, self-assembling systems, hydrogels, micro- and nanoparticles, coatings, films and membranes, capsules, vascular networks, shape memory or stimuli-induced self-healing materials, etc. They are able to spontaneously repair themselves after damage or degradation, recovering structural integrity and functionality by increasing the rate of healing versus the rate of damage. A recent published approach  (Polymers 2022, 14, 130) is a synergetic combination of the polymer characteristics with those of proteins/peptides in order to prepare stable networks with high elasticity and self-healing ability, suitable for biomedical applications.
  • 618
  • 29 Mar 2022
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