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Benzofuran derivatives are synthetic compounds that are finding an increasing interest in the scientific community not only as building blocks for the realization of new materials, but also as potential drugs thanks to their ability to interact with nucleic acids, interfere with the amyloid peptide aggregation and cancer cell cycle. However, their ability to interact with proteins is a theme still in need of investigation for the therapeutic importance that benzofurans could have in the modulation of protein-driven processes, and for the possibility of making use of serum albumins as benzofurans delivery systems.
Δ(BF1-BSA) (%) | Δ(BDF1-BSA) (%) | |
---|---|---|
α | +0.06 | −0.79 |
β | +5.70 | +1.00 |
Random coil | −5.76 | −0.21 |
Compound | Tm/°C | ΔT/°C = (Tm − TmBSA) |
---|---|---|
BF1-BSA | 72.9 ± 0.1 | +3.1 ± 0.2 |
BDF1-BSA | 69.0 ± 0.2 | −0.8 ± 0.1 |