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Topic Review
Multifunctional Polymeric Nanogels for Biomedical Applications
Currently, research in nanoparticles as a drug delivery system has broadened to include their use as a delivery system for bioactive substances and a diagnostic or theranostic system. Nanogels, nanoparticles containing a high amount of water, have gained attention due to their advantages of colloidal stability, core-shell structure, and adjustable structural components. These advantages provide the potential to design and fabricate multifunctional nanosystems for various biomedical applications. Modified or functionalized polymers and some metals are components that markedly enhance the features of the nanogels, such as tunable amphiphilicity, biocompatibility, stimuli-responsiveness, or sensing moieties, leading to specificity, stability, and tracking abilities. 
  • 853
  • 07 Dec 2021
Topic Review
Multienzymatic Processes Involving Baeyer–Villiger Monooxygenases
Baeyer–Villiger monooxygenases (BVMOs) are flavin-dependent oxidative enzymes capable of catalyzing the insertion of an oxygen atom between a carbonylic Csp2 and the Csp3 at the alpha position, therefore transforming linear and cyclic ketones into esters and lactones. These enzymes are dependent on nicotinamides (NAD(P)H) for the flavin reduction and subsequent reaction with molecular oxygen. BVMOs can be included in cascade reactions, coupled to other redox enzymes, such as alcohol dehydrogenases (ADHs) or ene-reductases (EREDs), so that the direct conversion of alcohols or α,β-unsaturated carbonylic compounds to the corresponding esters can be achieved. 
  • 500
  • 11 May 2021
Topic Review
Multidrug Resistant Gram-Negative Bacteria
Antibiotic resistance has increased markedly in Gram-negative bacteria, causing severe infections intractable with traditional drugs and amplifying mortality and healthcare costs. Consequently, to find novel antimicrobial compounds, active on multidrug resistant bacteria, is mandatory. In this regard, cationic antimicrobial peptides (CAMPs)—able to kill pathogens on contact—could represent an appealing solution. However, low selectivity, hemolytic toxicity and cost of manufacturing, hamper their massive clinical application. In the recent years—starting from CAMPs as template molecules—less toxic and lower-cost synthetic mimics of CAMPs, including cationic peptides, polymers and dendrimers, have been developed. Although the pending issue of hemolytic toxicity and biodegradability is still left not completely solved, cationic antimicrobial polymers (CAPs), compared to small drug molecules, thanks to their high molecular weight, own appreciable selectivity, reduced toxicity toward eukaryotic cells, more long-term activity, stability and non-volatility. With this background, an updated overview concerning the state of the art of the main manufactured types of CAPs, active on Gram-negative bacteria, is herein reported, including synthetic procedure and action’s mechanism. Information about the antibacterial activity, advantages and drawbacks of the most appealing compounds was also provided.
  • 986
  • 28 Oct 2020
Topic Review
Multicomponent Shape-Memory Polymers
Shape-memory polymers (SMPs)  are often combined with other functional materials. For example, polymers, metals, or other inorganic materials, in the shape of particles, fibers, and laminates, are combined to create multicomponent systems. Since these multicomponent systems are built up from discrete phases consisting of SMPs mixed with other polymers at the macroscopic or molecular level or reinforced with other domains (e.g., inorganic particle), they are particularly suited for the realization of multifunctionality.
  • 382
  • 09 Aug 2022
Topic Review
Multicomponent Bargellini Reaction
The multicomponent reaction between phenol, chloroform and acetone is known as Bargellini reaction. In this  article we collected and discussed all the Bargellini and Bargellini-like reactions carried out over the years. The main goal is that this knowledge-sharing will help chemists to properly use this transformation and imagine novel reactivities based on it.
  • 1.8K
  • 08 Mar 2021
Topic Review
Multicatalytic Behavior of Ba0.85Ca0.15Ti0.9Zr0.1O3 Ceramic
Ferroelectric materials are known to possess multicatalytic abilities that are nowadays utilized for removing organic pollutants from water via piezocatalysis, photocatalysis, piezo-photocatalysis, and pyrocatalysis processes. The Ba0.85Ca0.15Ti0.9Zr0.1O3 (BCZTO) ceramic is one such ferroelectric composition that has been extensively studied for electrical and electronic applications. Furthermore, the BCZTO ceramic has also shown remarkable multicatalytic performance in water-cleaning applications. 
  • 307
  • 25 Oct 2023
Topic Review
Multi-Walled Carbon Nanotubes-Based Sensors
Extensive use of multi-walled carbon nanotube (MWCNT) has been done for the fabrication and implementation of flexible sensors due to their enhanced electrical, mechanical, and thermal properties. These nanotubes have been deployed both in pure and composite forms for obtaining highly efficient sensors in terms of sensitivity, robustness, and longevity.
  • 1.0K
  • 17 Mar 2021
Topic Review
Multi-Material 3D Printing of Functional Ceramic Devices
As an emerging technology, multi-material 3D printing offers increased complexity and greater freedom in the design of functional ceramic devices because of its unique ability to directly construct arbitrary 3D parts that incorporate multiple material constituents without an intricate process or expensive tools.
  • 956
  • 17 Nov 2022
Topic Review
Multi-Functionalized Nanocarriers for Breast Cancer Therapy
Breast cancer (BC) is one of the most prevalent cancers in women. This type of malignancy often starts from ductal hyper-proliferation with its expansion into benign tumors or metastatic carcinomas resulting from exposure to carcinogenic agents. This disease exhibits not only a great deal of heterogeneity but also a great deal of variation in its occurrence, treatment response, progression, and even location of metastasis. Multifunctional nanocarriers include polymeric nanoparticles (NPs), self-nanoemulsifying drug delivery systems (SNEDDS), liposomes, and mesoporous inorganic NPs. 
  • 341
  • 02 Aug 2022
Topic Review
Mucoadhesive Hydrogel Nanoparticles
Hydrogels are widely used materials which have many medical applications. Their ability to absorb aqueous solutions and biological fluids gives them innovative characterizations resulting in increased compatibility with biological activity. In this sense, they are used extensively for encapsulation of several targets such as biomolecules, viruses, bacteria, and mammalian cells. 
  • 518
  • 23 Jun 2021
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