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Topic Review
6-formyl-indolo(3,2-b)carbazole
6-formyl-indolo[3,2-b]carbazole (FICZ) (chemical formula C19H12N2O) is a nitrogen heterocycle, having an extremely high affinity (Kd = 7 x 10-11M) for binding to the Aryl hydrocarbon receptor (AhR). It was originally identified as a photooxidized derivative of the amino acid tryptophan and suggested to be the endogenous liagand of the AhR.
  • 535
  • 04 Nov 2022
Topic Review
Nanoporous Stainless Steel Materials for Body Implants
Despite the inadequate biocompatibility, medical-grade stainless steel materials have been used as body implants for decades. The desired biological response of surfaces to specific applications in the body is a highly challenging task, and usually not all the requirements of a biomaterial can be achieved. Nanostructured surfaces have shown intriguing results as cell selectivity can be achieved by specific surface nanofeatures. Nanoporous structures can be fabricated by anodic oxidation, which has been widely studied for titanium and its alloys, while no systematic studies are available for stainless steel (SS) materials.
  • 611
  • 04 Nov 2022
Topic Review
Date Rape Drug
A date rape drug is any drug that incapacitates another person and renders that person vulnerable to sexual assault, including rape. The substances are associated with date rape because of reported incidents of their use in the context of two people dating, during which the victim is sexually assaulted or raped or suffers other harm. The substances are not exclusively used to perpetrate sexual assault or rape, but are the properties or side-effects of substances normally used for legitimate medical purposes. One of the most common incapacitating agents for date rape is alcohol, administered either surreptitiously or consumed voluntarily, rendering the victim unable to make informed decisions or give consent.
  • 698
  • 04 Nov 2022
Topic Review
Organogold Chemistry
Organogold chemistry is the study of compounds containing gold–carbon bonds. They are studied in academic research, but have not received widespread use otherwise. The dominant oxidation states for organogold compounds are I with coordination number 2 and a linear molecular geometry and III with CN = 4 and a square planar molecular geometry. The first organogold compound discovered was gold(I) carbide Au2C2, which was first prepared in 1900.
  • 680
  • 04 Nov 2022
Topic Review
Immunomodulating Hydrogels for Drug Delivery Applications
One of the most concerning issues with conventional drug delivery platforms is the elicitation of an immune response upon implantation. Different natural and artificial platforms have been used for various biomedical applications ranging from drug and metabolite delivery, gene delivery, and wound healing/regenerative applications. However, most of these platforms suffer due to a compromise on immunogenicity and their respective biomedical applications. Although hydrogels from biomaterials of different origins have shown great promise in various biomedical applications, their immunogenicity, however small, is still a matter of concern, thus preventing their widespread clinical adoption. Hydrogels have been proposed as an excellent platform for various applications in drug delivery and regenerative medicine. Hydrogels are soft, tridimensional crosslinked networks of polymers with a high-water content, similar to the percentage found in human tissue.
  • 738
  • 04 Nov 2022
Topic Review
Organosilicon
Organosilicon compounds are organometallic compounds containing carbon–silicon bonds. Organosilicon chemistry is the corresponding science of their preparation and properties. Most organosilicon compounds are similar to the ordinary organic compounds, being colourless, flammable, hydrophobic, and stable to air. Silicon carbide is an inorganic compound.
  • 3.1K
  • 04 Nov 2022
Topic Review
Chemical Analysis of Synthetic Antioxidants in Foodstuffs
The information obtained by the systematic search in ScienceDirect® databases, indicated the predominance of the use of separation chromatography, followed by detection techniques in the development of analytical methods for the detection of phenolic antioxidants in foodstuffs. This is because these techniques allow the simultaneous determination of different types of antioxidants, through the separation of these compounds at different stages of a column, thus obtaining different retention times, which are related to the physicochemical characteristics of the antioxidants and their interaction between the stationary and mobile phase. After the separation, the antioxidants are identified and quantified using specific chromatographic detectors, such as ultraviolet–visible, diode array, thermal conductivity, and mass spectroscopy, resulting in a suitable sensitivity and selectivity. However, separation and detection chromatographic, despite being very accurate in the detection of antioxidants, have as their main disadvantage the use of large amounts of organic solvents or inert gases, with elevated purity and, consequently, high cost. Additionally, the use of these techniques requires rigorous steps of extraction and cleanup to prepare the foodstuff samples for analysis, remove interference compounds, and/or preconcentrate the antioxidants to obtain reliable information. Extraction steps can increase the time and costs in the analysis, promote a reduction in the analytical frequency, and generate a great quantity of residues, which goes against a very important principle, taken very seriously today, green chemistry, which orients the reduction or elimination of toxic residues in chemical products and processes, including all cycles of a chemical, in its design, manufacture, use, and final disposal.
  • 694
  • 04 Nov 2022
Topic Review
Strategies for Improving Cell-Penetrating Peptides Stability and Delivery
Peptides play an important role in many fields, including immunology, medical diagnostics, and drug discovery, due to their high specificity and positive safety profile. However, for their delivery as active pharmaceutical ingredients, delivery vectors, or diagnostic imaging molecules, they suffer from two serious shortcomings: their poor metabolic stability and short half-life. Major research efforts are being invested to tackle those drawbacks, where structural modifications and novel delivery tactics have been developed to boost their ability to reach their targets as fully functional species.
  • 798
  • 04 Nov 2022
Topic Review
Application of Laser-Induced Periodic Surface Structures (LIPSS)
As a laser technology, the femtosecond laser is used in biomedical fields due to its excellent performance—its ultrashort pulses, high instantaneous power, and high precision. As a surface treatment process, the femtosecond laser can prepare different shapes on metal surfaces to enhance the material’s properties, such as its wear resistance, wetting, biocompatibility, etc. Laser-induced periodic surface structures (LIPSSs) are a common phenomenon that can be observed on almost any material after irradiation by a linearly polarized laser. Surface texturing by laser irradiation can change various materials’ properties and create multifunctional surfaces. Materials can be better applied by customizing functional surfaces.
  • 1.1K
  • 04 Nov 2022
Topic Review
Maté (Drink)
User:RMCD bot/subject notice Maté or mate (/ˈmæteɪ/), also known as chimarrão or cimarrón, is a traditional South American caffeine-rich infused drink, that was consumed by the Guaraní and Tupí peoples. It is the National Beverage in Argentina, Uruguay and Paraguay. It is also consumed in the Bolivian Chaco, Southern Chile, Southern Brazil, Syria—the largest importer in the world—and Lebanon, where it was brought from Argentina by immigrants. It is prepared by steeping dried leaves of yerba mate (Ilex paraguariensis, known in Portuguese as erva-mate) in hot water and is served with a metal straw from a shared hollow calabash gourd. The straw is called a bombilla in Spanish, a bomba in Portuguese, and a bombija or, more generally, a masassa (straw) in Arabic. The straw is traditionally made of silver. Modern, commercially available straws are typically made of nickel silver (called alpaca), stainless steel, or hollow-stemmed cane. The gourd is known as a mate or a guampa; while in Brazil, it has the specific name of cuia, or also cabaça (the name for Indigenous-influenced calabash gourds in other regions of Brazil, still used for general food and drink in remote regions). Even if the water is supplied from a modern thermos, the infusion is traditionally drunk from mates or cuias. The maté leaves are dried, chopped, and ground into a powdery mixture called yerba, "erva" in Portuguese, which means "herb". The bombilla functions as both a straw and a sieve. The submerged end is flared, with small holes or slots that allow the brewed liquid in, but block the chunky matter that makes up much of the mixture. A modern bombilla design uses a straight tube with holes, or a spring sleeve to act as a sieve. "Tea-bag" type infusions of maté (Spanish: mate cocido, Portuguese: chá mate) have been on the market in many South American countries for many years under such trade names as "Taragüi" in Argentina, "Pajarito" and "Kurupí" in Paraguay, and Matte Leão and "Mate Real" in Brazil.
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  • 03 Nov 2022
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