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Topic Review
Poly(N-isopropylacrylamide)-Based Hydrogels
Poly(N-isopropylacrylamide) (PNIPAM) is a widely utilized negative thermosensitive polymer (as it has increased solubility with lowering of temperature, causing volume phase transition by forming hydrogen bonds) that has currently sparkled a lot of scientific inquisitiveness. Smart hydrogels based on PNIPAM demonstrate distinct thermoresponsive features close to a lower critical solution temperature (LCST) that enhance their capability in various biomedical applications such as drug delivery, tissue engineering, and wound dressings.
  • 3.3K
  • 29 Jul 2022
Topic Review
Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery
Poly(α-L-glutamic acid) (PGA) is a class of synthetic polypeptides composed of the monomeric unit α-L-glutamic acid. Owing to their biocompatibility, biodegradability, and non-immunogenicity, PGA-based nanomaterials have been elaborately designed for drug delivery systems.
  • 578
  • 07 May 2022
Topic Review
Poly Drug Use
Poly drug use or polysubstance use refers to the use of combined psychoactive substances for recreational purposes. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.
  • 694
  • 17 Nov 2022
Topic Review
Poly (Butylene Succinate) and PBS Copolyesters Degradation
The impact of plastics on the environment can be mitigated by employing biobased and/or biodegradable materials (i.e., bioplastics) instead of the traditional “commodities”. Poly (butylene succinate) (PBS) emerges as one of the most promising alternatives due to its good mechanical, thermal, and barrier properties, making it suitable for use in a wide range of applications. Nevertheless, less information regarding PBS biodegradation is available, as research is still ongoing. PBS degradation methods include hydrolytic degradation, enzymatic degradation, and biodegradation in environmental conditions, such as burial, activated sludge, and compost.
  • 2.7K
  • 22 Mar 2022
Topic Review
Polarization Holography
Polarization holography has the unique capacity to record and retrieve the amplitude, phase, and polarization of light simultaneously in a polarization-sensitive recording material and has attracted widespread attention. Polarization holography is a noteworthy technology with potential applications in the fields of high-capacity data storage, polarization-controlled optical elements, and other related fields.
  • 2.2K
  • 23 Jan 2021
Topic Review
PN Drugs Against Intracellular Infections
Polymeric nanocarriers (PNs) are a promising alternative for delivering intracellularly antimicrobials of high toxicity, low solubility and low bioavailability to reduce dose and side effects and improve their therapeutic efficacy. They may prevent unwanted drug interactions and degradation thus decreasing the development of resistance in microorganisms. 
  • 534
  • 25 Aug 2020
Topic Review
Platinum-Based Nanoformulations for Glioblastoma Treatment
Therapies for treating Glioblastoma (GB), and brain tumours in general, are inefficient and represent numerous challenges. In addition to surgical resection, chemotherapy and radiotherapy are presently used as standards of care. However, treated patients still face a dismal prognosis with a median survival below 15–18 months. Temozolomide (TMZ) is the main chemotherapeutic agent administered; however, intrinsic or acquired resistance to TMZ contributes to the limited efficacy of this drug. To circumvent the current drawbacks in GB treatment, a large number of classical and non-classical platinum complexes have been prepared and tested for anticancer activity, especially platinum (IV)-based prodrugs. Platinum complexes, used as alkylating agents in the anticancer chemotherapy of some malignancies, are though often associated with severe systemic toxicity (i.e., neurotoxicity), especially after long-term treatments.
  • 311
  • 22 May 2023
Topic Review
Platinum Based Cytostatic Drugs
Platinum based cytostatic drugs (Pt CDs) are among the most used drugs in cancer treatments which are administered via intravenous infusion and released partially intact or as transformation products. 
  • 736
  • 19 Apr 2022
Topic Review
Platinum and Palladium Solvent Extraction of Spent Catalysts
The strategic importance of platinum and palladium, two platinum-group metals (PGMs), is particularly supported by their technological applications, one of the most relevant being the role they perform as catalysts for several sorts of chemical reactions.
  • 496
  • 03 Aug 2023
Topic Review
Platelet-Rich Fibrin in Bone Regenerative
Background: Preservation of the alveolar bone is determinant in the outcome of orthodontic treatment. Alveolar bone defects or decrease of its height and width may occur due to common reasons such as inflammation, tooth extraction or cleft lip and palate. The aim of this systematic review was to investigate and appraise the quality of the most up to date available evidence regarding the applications and effects of platelet-rich fibrin (PRF) in orthodontics. Methods: This study was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using the following databases: Medline via PubMed, Cochrane Library, Web of Science Core Collection and EMBASE. The qualitative assessment of the included studies was performed using Cochrane Risk of Bias tool and ROBINS-I guidelines. Results: From a total of 489 studies, 9 studies were selected. The majority of the included studies demonstrate that autogenous anterior iliac graft with PRF had higher amount of newly formed bone. Furthermore, this review also suggests that application of platelets derivatives in the extraction socket can accelerate orthodontic tooth movement. Conclusion: Despite the limitations in the included studies, this systematic review suggested that PRF can improve alveolar cleft reconstruction and orthodontic tooth movement.
  • 693
  • 29 Oct 2020
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