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Topic Review
Proteasome Structure and Function in Multiple Myeloma
Multiple myeloma (MM) is an aggressive and incurable disease for most patients, characterized by periods of treatment, remission and relapse. The introduction of new classes of drugs, such as proteasome inhibitors (PIs), has improved survival outcomes in these patient populations. The proteasome is the core of the ubiquitin–proteasome system (UPS), a complex and conserved pathway involved in the control of multiple cellular processes, including cell cycle control, transcription, DNA damage repair, protein quality control and antigen presentation. 
  • 512
  • 23 Feb 2023
Topic Review
Proteasome Inhibitors
Proteasome inhibitors have shown relevant clinical activity in several hematological malignancies, namely in multiple myeloma and mantle cell lymphoma, improving patient outcomes such as survival and quality of life, when compared with other therapies. However, initial response to the therapy is a challenge as most patients show an innate resistance to proteasome inhibitors, and those that respond to the therapy usually develop late relapses suggesting the development of acquired resistance. The mechanisms of resistance to proteasome inhibition are still controversial and scarce in the literature.
  • 876
  • 18 Apr 2022
Topic Review
Prospect Biomedical Applications of Novel Functional Metallic Glasses
The continuous development of novel materials for biomedical applications is resulting in an increasingly better prognosis for patients. The application of more advanced materials relates to fewer complications and a desirable higher percentage of successful treatments. New, innovative materials being considered for biomedical applications are metallic alloys with an amorphous internal structure called metallic glasses. They are currently in a dynamic phase of development both in terms of formulating new chemical compositions and testing their properties in terms of intended biocompatibility. 
  • 632
  • 28 Nov 2022
Topic Review
Propylene Synthesis
Propylene is one of the most important feedstocks in the chemical industry, as it is used in the production of widely diffused materials such as polypropylene. Conventionally, propylene is obtained by cracking petroleum-derived naphtha and is a by-product of ethylene production. To ensure adequate propylene production, an alternative is needed, and propane dehydrogenation is considered the most interesting process.
  • 2.5K
  • 25 Oct 2021
Topic Review
Proposed Strategies for Higher Performance in Supercapacitors
The urgent need for efficient energy storage devices (supercapacitors and batteries) has attracted ample interest from scientists and researchers in developing materials with excellent electrochemical properties. Electrode material based on carbon, transition metal oxides, and conducting polymers (CPs) has been used. Among these materials, carbon has gained wide attention in Electrochemical double-layer capacitors (EDLC) due to its variable morphology of pores and structural properties as well as its remarkable electrical and mechanical properties. In this context, the present work summarizes the history of supercapacitors, the type of carbon electrode materials, and the different strategies to improve the performance of these devices. In addition, different approaches to studying the charging mechanism of these devices through different electrochemical techniques are presented, including advantages and challenges. Since a deeper understanding of the interfacial charge storage mechanisms is also crucial in the elaboration and performance of the electrode material.
  • 300
  • 12 Oct 2023
Topic Review
Propolis in Protecting the Skeleton
Chronic inflammation and oxidative stress are two major mechanisms leading to the imbalance between bone resorption and bone formation rate, and subsequently, bone loss. Thus, functional foods and dietary compounds with antioxidant and anti-inflammatory could protect skeletal health. This review aims to examine the current evidence on the skeletal protective effects of propolis, a resin produced by bees, known to possess antioxidant and anti-inflammatory activities.
  • 757
  • 02 Jun 2021
Topic Review
Property-Dependent Applications of Melanin
Melanin is among the most important natural pigments produced by various organisms, from microbes to plants and mammals. Melanins possess great properties such as radioprotective and antioxidant activity, heavy metal chelation and absorption of organic compounds. Melanin constitutes a complex polymer that can be exploited in multiple biotechnological, medicinal, and environmental sectors due to its unique properties of radioprotection, antioxidant activity, chelation of heavy metals and absorption of organic compounds.
  • 309
  • 09 May 2023
Topic Review
Properties of TiO2 Films
For many years, TiO2-based materials and improving their properties in order to expand their application areas have been the focus of numerous research groups. Various innovative approaches have been proposed to improve the photocatalytic and gas-sensing properties of TiO2 nanostructures.
  • 253
  • 15 Dec 2023
Topic Review
Properties of Seashells
Researchers around the world have conducted extensive experiments with waste seashells in the form of seashell aggregates and seashell powder. The physical, mechanical, and durability properties of seashell concrete are largely determined by the properties of the aggregates and powders that make up the shell.
  • 591
  • 21 Mar 2024
Topic Review
Properties of Phase Change Materials
The main drawback of phase change materials (PCMs) is their low thermal conductivity, which limits the possibilities of a wide range of implementations. Therefore, the researchers, as found in the literature, proposed several methods to improve the thermal conductivity of PCMs, including inserting high thermal conductivity materials in nano-, micro-, and macro-scales, as well as encapsulation of PCMs. However, these inserts impact the other properties of PCMs like latent heat, melting temperature, thermal stability, and cycling stability. 
  • 5.1K
  • 18 Sep 2021
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