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Topic Review
Biography
Topic Review
Benzil
Benzil (BZ) can be converted almost quantitatively to benzoyl peroxide (BP) in aerated polymer films upon irradiation at >400 nm (i.e., the long-wavelength edge of the n→π* absorption band of BZ, where BP does not absorb).
1.2K
20 Sep 2021
Topic Review
Microelectronics for E-Textile
Modern electronic textiles are moving towards flexible wearable textiles, so-called e-textiles that have micro-electronic elements embedded onto the textile fabric that can be used for varied classes of functionalities. There are different methods of integrating rigid microelectronic components into/onto textiles for the development of smart textiles, which include, but are not limited to, physical, mechanical, and chemical approaches. The integration systems must satisfy being flexible, lightweight, stretchable, and washable to offer a superior usability, comfortability, and non-intrusiveness. Furthermore, the resulting wearable garment needs to be breathable.
1.2K
17 Sep 2021
Topic Review
Powder bed fusion in dentistry
Complex dental component which are individually tailored to the patient can be obtain due to new 3D printing technology. Understanding the manufacturing and post-production processes is essential in order to obtain a product which can be used in clinical applications.
1.2K
20 Aug 2020
Topic Review
Computational Drug Design of TB
Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that inhibit its essential proteins is an appealing strategy for combating the global tuberculosis (TB) epidemic. Finding a compound that can target a particular cavity in a protein and interrupt its enzymatic activity is the crucial objective of drug design and discovery. Such a compound is then subjected to different tests, including clinical trials, to study its effectiveness against the pathogen in the host. In recent times, new techniques, which involve computational and analytical methods, enhanced the chances of drug development, as opposed to traditional drug design methods, which are laborious and time-consuming. The computational techniques in drug design have been improved with a new generation of software used to develop and optimize active compounds that can be used in future chemotherapeutic development to combat global tuberculosis resistance.
1.2K
17 Dec 2021
Biography
Matthew H. Todd
Matthew Houghton Todd (born 13 January 1973) is a British chemist and the Professor and Chair of Drug Discovery of the School of Pharmacy at University College London.[1] He is the founder of Open Source Malaria (OSM) and his research focuses on drug discovery and development for this disease.[2][3][4][5][6] Recently, he has expanded to other areas, particularly neglected diseases such as tuberc
1.2K
23 Nov 2022
Topic Review
CNT-Based Chemical Sensors
Carbon nanotubes (CNTs) combine high electrical conductivity with high surface area and chemical stability, which makes them very promising for chemical sensing.
1.2K
10 Feb 2022
Topic Review
Diels–Alder Cycloaddition Reactions
Diels–Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most cases with high regio- and stereoselectivity. An insight into the most relevant advances on sustainable Diels–Alder reactions since 2010 is provided. Various environmentally benign solvent systems are discussed, namely bio-based derived solvents, polyethylene glycol, deep eutectic solvents, supercritical carbon dioxide, water and water-based aqueous systems.
1.2K
25 Mar 2022
Topic Review
Dapsone Imine Derivatives
Dapsone (DDS) is an antibacterial drug with well-known antioxidant properties. However, the antioxidant behavior of its derivatives has not been well explored. In the present work, the antioxidant activity of 10 dapsone derivatives 4-substituted was determined by an evaluation in two in vitro models (DPPH radical scavenging assay and ferric reducing antioxidant power). These imine derivatives 1–10 were obtained through condensation between DDS and the corresponding aromatic aldehydes 4-substuited. Three derivatives presented better results than DDS in the determination of DPPH (2, 9, and 10). Likewise, we have three compounds with better reducing activity than dapsone (4, 9, and 10). In order to be more insight, the redox process, a conceptual DFT analysis was carried out. Molecular descriptors such as electronic distribution, the total charge accepting/donating capacity (I/A), and the partial charge accepting/donating capacity (ω+/ω−) were calculated to analyze the relative donor-acceptor capacity through employing a donor acceptor map (DAM). The DFT calculation allowed us to establish a relationship between GAPHOMO-LUMO and DAM with the observed antioxidant effects. According to the results, we concluded that compounds 2 and 3 have the lowest Ra values, representing a good antioxidant behavior observed experimentally in DPPH radical capturing. On the other hand, derivatives 4, 9, and 10 display the best reducing capacity activity with the highest ω− and Rd values. Consequently, we propose these compounds as the best antireductants in our DDS imine derivative series.
1.2K
08 Oct 2021
Topic Review
Bioconversion of Starch Base Food Waste into Bioethanol
Food wastes are organic wastes or biodegradables. They are generated from various sources such as restaurants and cafeterias, industrial sectors, commercial and domestic kitchens, food processing plants, and other areas where a large number of people consume food. The global demand for fuel keeps increasing daily. The massive depletion of fossil fuels and their influence on the environment as pollution is a severe problem. Meanwhile, food waste disposal is also a complex problem in solid-waste management since one-third of every food consumed is discarded as waste. The standard waste management methods, including food waste incineration and landfilling, are considered hazardous to the environment. Food waste constituents are majorly starch-based and contain various biomolecules, including sugar, lipids, proteins, vitamins, cellulose, etc. These polysaccharides can be hydrolysed into monosaccharides such as glucose, which can then be fermented using microorganisms to produce ethanol through the fermenting of sugars derived from enzymatic hydrolysis treatment of food wastes. The human food system is rich in starch, which can be a potential resource for bioethanol production.
1.2K
20 Sep 2022
Topic Review
Shugoshin
Shugoshin (meaning “guardian spirit” in Japanese) is a homo-dimeric phospho-protein belonging to the shugoshin protein family. Shugoshin is conserved from single-celled yeast to multicellular mammals including humans. Shugoshin shares several structural features with other members of the shugoshin family, including a basic region at the C-terminus that is essential for centromere binding, chromosome localization, and an N-terminal coiled-coil domain that may regulate its dimerization and interaction with other proteins.
1.2K
27 Jul 2021
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