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Topic Review
MALDI Mass Spectrometry
MALDI Mass Spectrometry is an analytical technique able to study the complex interdependency between chemical interaction and structural conformation of several protein based assemblies.
  • 1.4K
  • 16 Nov 2020
Topic Review
Hsp90 C-Terminal Inhibitors
Hsp90 is a molecular chaperone with over 300 client proteins that act in the cell cycle and in signalling processes. Disruption of Hsp90 chaperone activity by inhibitors induces simultaneous proteasomal degradation of many deregulated oncoproteins that are critical for all fundamental hallmarks of cancers. To date, mainly Hsp90 N-terminal domain inhibitors have been developed for cancer treatments; however, several of these have not been successful in clinical trials, often due to toxicity. One of the major drawbacks associated with Hsp90 N-terminal domain inhibition is induction of the pro-survival heat-shock response. This response results in increased levels of Hsp90 and anti-apoptotic proteins, such as heat shock factor 1 (HSF-1), Hsp27 and Hsp70, which initiate anti-apoptotic cascades and promote drug resistance, a highly problematic property of any anticancer drug. In contrast, Hsp90 C-terminal inhibitors do not induce the heat shock response, and are therefore promising novel agents for treatment of different cancers.
  • 1.4K
  • 09 Nov 2020
Topic Review
Rhamnus (Genus)
Rhamnus is a genus of about 110 accepted species of shrubs or small trees, commonly known as buckthorns in the family Rhamnaceae. Its species range from 1 to 10 meters tall (rarely to 15 m) and are native mainly in east Asia and North America, but found throughout the temperate and subtropical Northern Hemisphere, and also more locally in the subtropical Southern Hemisphere in parts of Africa and South America. Both deciduous and evergreen species occur. The leaves are simple, 3 to 15 centimeters long, and arranged alternately or in opposite pairs, or almost paired (subopposite). One distinctive character of many buckthorns is the way the veination curves upward towards the tip of the leaf. The plant bears fruits which are black or red berry-like drupe. The name is due to the woody spine on the end of each twig in many species. In the United States , Buckthorn is considered an invasive species by many local jurisdictions and state governments, such as Minnesota or Wisconsin.
  • 1.4K
  • 31 Oct 2022
Topic Review
Unsaturated Fat
An unsaturated fat is a fat or fatty acid in which there is at least one double bond within the fatty acid chain. A fatty acid chain is monounsaturated if it contains one double bond, and polyunsaturated if it contains more than one double bond. Where double bonds are formed, hydrogen atoms are subtracted from the carbon chain. Thus, a saturated fat has no double bonds, has the maximum number of hydrogens bonded to the carbons, and therefore is "saturated" with hydrogen atoms. In cellular metabolism, unsaturated fat molecules contain somewhat less energy (i.e., fewer calories) than an equivalent amount of saturated fat. The greater the degree of unsaturation in a fatty acid (i.e., the more double bonds in the fatty acid) the more vulnerable it is to lipid peroxidation (rancidity). Antioxidants can protect unsaturated fat from lipid peroxidation.
  • 1.4K
  • 28 Sep 2022
Topic Review
Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with widespread barrier dysfunction and T helper 2 (Th2) cytokines. AD is an imbalance in the Th2 immune response where there is an increase in the gene expression levels of major Th2 cytokines during the acute phase.
  • 1.4K
  • 07 Mar 2022
Topic Review
Rice Husk Reinforced Polymer Composites
Rice (Oryza sativa L. genus) is the primary source of daily food intake and has become the world’s second most important cereal crop sector due to the demand of billions of human beings. Rice husk (RH) should never be burned, due to various reasons, such as the ashes, harmful gases, and fumes that contribute to air pollution. Typically, the RH can be used as biochar, extracted silica, or husk itself. In general, RH is a hull to protect seeds or grains. It is formed from rigid materials, is water-insoluble, and is abrasive, with a high level of cellulose–silica structures. The exterior of the hulls consists of silica covered with a cuticle, with a small amount of silica content at the innermost epidermis. The exploitation of RH residues in biocomposites offers multiple advantages, for example, reducing the relative amount of constituents derived from synthetic polymers, such as resin polymers and some additives. The tensile strength is mainly used to evaluate the strength behavior of a composite material. 
  • 1.4K
  • 04 Aug 2021
Topic Review
Enhancing Lithium-Manganese Oxide Electrochemical Behavior
Lithium manganese oxide is regarded as a capable cathode material for lithium-ion batteries, but it suffers from relative low conductivity, manganese dissolution in electrolyte and structural distortion from cubic to tetragonal during elevated temperature tests. 
  • 1.4K
  • 27 Apr 2021
Topic Review
Thermoresponsive Hydrogel Molecule
Temperature-induced, rapid changes in the viscosity and reproducible 3-D structure formation makes thermos-sensitive hydrogels an ideal delivery system to act as a cell scaffold or a drug reservoir. Moreover, the hydrogels’ minimum invasiveness, high biocompatibility, and facile elimination from the body have gathered a lot of attention from researchers.
  • 1.4K
  • 08 Aug 2022
Topic Review
Earwax
Earwax, also known by the medical term cerumen, is a brown, orange, red, yellowish or gray waxy substance secreted in the ear canal of humans and other mammals. It protects the skin of the human ear canal, assists in cleaning and lubrication, and provides protection against bacteria, fungi, and water. Earwax consists of dead skin cells, hair, and the secretions of cerumen by the ceruminous and sebaceous glands of the outer ear canal. Major components of earwax are long chain fatty acids, both saturated and unsaturated, alcohols, squalene, and cholesterol. Excess or compacted cerumen is the buildup of ear wax causing a blockage in the ear canal and it can press against the eardrum or block the outside ear canal or hearing aids, potentially causing hearing loss.
  • 1.4K
  • 07 Nov 2022
Topic Review
Hard Tissue Engineering
Hard tissues, e.g., bone, are mechanically stiff and, most typically, mineralized. To design scaffolds for hard tissue regeneration, mechanical, physico-chemical and biological cues must align with those found in the natural tissue. Combining these aspects poses challenges for material and construct design.  They can be fulfilled in top-down tissue engineering or bottom up biofabrication approaches upon employing biomaterials e.g. silk.
  • 1.4K
  • 18 Mar 2021
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