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Topic Review
Metals in Parkinson’s and Alzheimer’s Diseases
Metal ions are fundamental to guarantee the regular physiological activity of the human organism. They are involved in several biological processes such as electron transfer, oxygen transport, the maintenance of osmotic pressure, and the regulation of DNA transcription. Metals such as iron, cobalt, selenium, copper, zinc, and manganese are essential for human life and are usually required in trace amounts. On the other hand, aluminum, mercury, arsenic, and others are considered non-essential metals since they possess no biological function. The importance of metals in the human organism is so fundamental that several pathologies, among which are neurodegenerative diseases (NDs), are related to a common phenomenon known as metal dyshomeostasis.
  • 579
  • 28 Jul 2023
Topic Review
Hydrogel in Bone/Cartilage Regeneration
Hydrogel is a polymer matrix containing a large amount of water. It is similar to extracellular matrix components. It comes into contact with blood, body fluids, and human tissues without affecting the metabolism of organisms. It can be applied to bone and cartilage tissues. 
  • 578
  • 16 Mar 2021
Topic Review
CrkL during Bone Remodeling
Coupled signaling between bone-forming osteoblasts and bone-resorbing osteoclasts is crucial to the maintenance of bone homeostasis. We previously reported that v-crk avian sarcoma virus CT10 oncogene homolog-like (CrkL), which belongs to the Crk family of adaptors, inhibits bone morphogenetic protein 2 (BMP2)-mediated osteoblast differentiation, while enhancing receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclast differentiation. In this study, we investigated whether CrkL can also regulate the coupling signals between osteoblasts and osteoclasts, facilitating bone homeostasis. Osteoblastic CrkL strongly decreased RANKL expression through its inhibition of runt-related transcription factor 2 (Runx2) transcription. Reduction in RANKL expression by CrkL in osteoblasts resulted in the inhibition of not only osteoblast-dependent osteoclast differentiation but also osteoclast-dependent osteoblast differentiation, suggesting that CrkL participates in the coupling signals between osteoblasts and osteoclasts via its regulation of RANKL expression. Therefore, CrkL bifunctionally regulates osteoclast differentiation through both a direct and indirect mechanism while it inhibits osteoblast differentiation through its blockade of both BMP2 and RANKL reverse signaling pathways. Collectively, these data suggest that CrkL is involved in bone homeostasis, where it helps to regulate the complex interactions of the osteoblasts, osteoclasts, and their coupling signals.
  • 578
  • 20 Jul 2021
Topic Review
Synthesis and Structures of MXenes
Among various two−dimensional (2D) materials, MXenes have attracted widespread interest due to their unique surface properties, as well as mechanical, optical, electrical and biocompatible properties, and have been applied in various fields, particularly in the preparation of biosensors, which play a critical role. 
  • 578
  • 19 Oct 2022
Topic Review
Cadmium Poisoning
Cadmium is a naturally occurring toxic metal with common exposure in industrial workplaces, plant soils, and from smoking. Due to its low permissible exposure in humans, overexposure may occur even in situations where trace quantities of cadmium are found. Cadmium is used extensively in electroplating, although the nature of the operation does not generally lead to overexposure. Cadmium is also found in some industrial paints and may represent a hazard when sprayed. Operations involving removal of cadmium paints by scraping or blasting may pose a significant hazard. The primary use of cadmium is in the manufacturing of NiCd rechargeable batteries. The primary source for cadmium is as a byproduct of refining zinc metal. Exposures to cadmium are addressed in specific standards for the general industry, shipyard employment, the construction industry, and the agricultural industry.
  • 578
  • 19 Oct 2022
Topic Review
Binary Chalcogenides and Their Photocatalytic Water-Splitting Activities
Chalcogenides are essential in the conversion of solar energy into hydrogen fuel due to their narrow band gap energy. H2 is a clean fuel, and its usage can address many of the issues caused by using fossil fuels. It is widely used as a feedstock in the chemical industry to produce ammonia, methanol, and various fuels like diesel, gasoline, etc. It is also used as a transport fuel. It has several other applications in the production of metals and agricultural industries. A cost-effective and long-lasting chalcogenide-based photocatalysts can make the H2 generating process more economical and suitable. The use of binary chalcogenides and their modifications (compounds consisting of only one chalcogen and one electropositive atom) for photocatalytic water splitting will be discussed in the following subsections.
  • 578
  • 08 Nov 2022
Topic Review
Graphene Oxide Hybrids for Environmental Applications
Graphene-oxide-based metal hybrids (GM) are used for the rapid and efficient reduction and removal of toxic adulterants in the environment. The exceptionally high specific surface area, versatile surface chemistry, and exceptional customization efficiency of graphene oxide nanosheets combined with the adaptable chemistry of metal nanoparticles enable the formation of GM hybrid nanocomposites. However, little is known about the architecture of GM nanocomposite engineering, interaction mechanisms, and environmental compatibility.
  • 578
  • 28 Dec 2022
Topic Review
Bioactive Compounds from Fruit Crop Wastes
The food industry as a whole is one of the main contributors for food losses and waste generation. To deal with such wastes, research and efforts have been made for the development and valorization of bioactive compounds present in food wastes such as leaves, peels, seeds, and pulp.
  • 578
  • 10 Feb 2023
Topic Review
Nano/Microrobots in Action for Gastrointestinal Tract Diseases
Nano/microrobots (NMRs) are tiny devices that can convert energy into motion and operate at nano/microscales.54 Especially in biomedical research, NMRs have received much attention over the past twenty years because of their excellent capabilities and great potential in various applications, including on-demand drug delivery, gene and cell transport, and precise microsurgery. Reports published in recent years show that synthetic nano/microrobots have promising potential to function in the gastrointestinal (GI) region, particularly in terms of drug delivery.
  • 577
  • 20 Jan 2022
Topic Review
Protein Binding of Benzofuran Derivatives
Benzofuran derivatives are synthetic compounds that are finding an increasing interest in the scientific community not only as building blocks for the realization of new materials, but also as potential drugs thanks to their ability to interact with nucleic acids, interfere with the amyloid peptide aggregation and cancer cell cycle. However, their ability to interact with proteins is a theme still in need of investigation for the therapeutic importance that benzofurans could have in the modulation of protein-driven processes, and for the possibility of making use of serum albumins as benzofurans delivery systems.
  • 577
  • 29 Mar 2022
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