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Topic Review
Natural and Synthetic Halogenated Amino Acids
The 3D structure and surface characteristics of proteins and peptides are crucial for interactions with receptors or ligands and can be modified to some extent to modulate their biological roles and pharmacological activities. The introduction of halogen atoms on the side-chains of amino acids is a powerful tool for effecting this type of tuning, influencing both the physico-chemical and structural properties of the modified polypeptides, helping to first dissect and then rationally modify features that affect their mode of action.
  • 833
  • 16 Dec 2021
Topic Review
Annatto
Annatto (/əˈnætoʊ/ or /əˈnɑːtoʊ/) is an orange-red condiment and food coloring derived from the seeds of the achiote tree (Bixa orellana), native to tropical America. It is often used to impart a yellow or orange color to foods, but sometimes also for its flavor and aroma. Its scent is described as "slightly peppery with a hint of nutmeg" and flavor as "slightly nutty, sweet and peppery". The color of annatto comes from various carotenoid pigments, mainly bixin and norbixin, found in the reddish waxy coating of the seeds. The condiment is typically prepared by grinding the seeds to a powder or paste. Similar effects can be obtained by extracting some of the color and flavor principles from the seeds with hot water, oil, or lard, which are then added to the food. Annatto and its extracts are now widely used in an artisanal or industrial scale as a coloring agent in many processed food products, such as cheeses, dairy spreads, butter and margarine, custards, cakes and other baked goods, potatoes, snack foods, breakfast cereals, smoked fish, sausages, and more. In these uses, annatto is a natural alternative to synthetic food coloring compounds, but it has been linked to rare cases of food-related allergies. Annatto is of particular commercial value in the United States because the Food and Drug Administration considers colorants derived from it to be "exempt of certification".
  • 833
  • 20 Oct 2022
Topic Review
Electrospun Polymer Nanofibers in Photocatalytic Hybrid Materials
A wide variety of materials, strategies, and methods have been proposed to face the challenge of wastewater pollution. The most innovative and promising approaches include the hybrid materials made of polymeric nanofibers and photocatalytic nanoparticles. Electrospun nanofibers with unique properties, such as nanosized diameter, large specific surface area, and high aspect ratio, represent promising materials to support and stabilize photocatalytic nanosized semiconductors. Additionally, the role performed by polymer nanofibers can be extended even further since they can act as an active medium for the in situ synthesis of photocatalytic metal nanoparticles or contribute to pollutant adsorption, facilitating their approach to the photocatalytic sites and their subsequent photodegradation. 
  • 832
  • 10 Mar 2022
Topic Review
High-Entropy Alloy
Cutting edge of high-entropy alloy superconductors from the perspective of materials research.
  • 831
  • 26 Oct 2020
Topic Review
Chemical Safety
Chemicals as elements, compounds, mixtures, solutions and emulsions are very widely used and transported in the modern industrial society. Of necessity, they are also used in schools, universities and other training facilities to educate pupils in their safe use and handling and also are commonly used in domestic situations for cleaning, gardening and DIY. However, there are chemicals that should not mix or get in contact with others, as they can produce byproducts that may be toxic, carcinogenic, explosive etc, or can be dangerous themselves. To avoid disasters and mishaps, maintaining safety is considered paramount, especially by chemists. Chemical safety includes all those policies, procedures and practices designed to minimise the risk of exposure to potentially hazardous chemicals. This includes the risks of exposure to persons handling the chemicals, to the surrounding environment, and to the communities and ecosystems within that environment. The hazardous nature of many chemicals may be increased when mixed with other chemicals, heated or handled inappropriately. In a chemically safe environment, users are able to take appropriate actions in case of accidents although many incidents of exposure to chemical hazards occur outside of a controlled environments such as manufacturing plants or laboratories. It is estimated that 1.6 million human deaths occur each year from contact with hazardous chemicals. and that in 2016, 45 million disability-adjusted life-years were lost, a significant increase from 2012.
  • 831
  • 21 Nov 2022
Topic Review
Therapeutic Applications of Nano-Phytopharmaceuticals
Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side effects compared to modern medicines. Dose reduction, improved bioavailability, receptor-selective binding, and targeted delivery of phytopharmaceuticals can be likely achieved by molding them into specific nano-formulations. 
  • 830
  • 25 Jan 2022
Topic Review
Next-Generation Gingival Graft Substitutes
There is a shortage of suitable tissue-engineered solutions for gingival recession, a soft tissue defect of the oral cavity. Autologous tissue grafts lead to an increase in morbidity due to complications at the donor site. Although material substitutes are available on the market, their development is early, and work to produce more functional material substitutes is underway. The latter materials along with newly conceived tissue-engineered substitutes must maintain volumetric form over time and have advantageous mechanical and biological characteristics facilitating the regeneration of functional gingival tissue.
  • 830
  • 17 May 2022
Topic Review
Aptamer-Sensors for Quantification of AFB1
Aflatoxin B1 (AFB1) is one of the most frequently-found mycotoxins in contaminated food. As the content of mycotoxins is particularly low in food, the development of probes to detect AFB1 in foods with high sensitivity and selectivity is an urgent social need for the evaluation of food quality. Numerous techniques have been developed to monitor AFB1. Nevertheless, most of them require cumbersome, labor-consuming, and sophisticated instruments, which have limited their application. An aptamer is a single, short nucleic acid sequence that is capable of recognizing different targets. Owing to their unique properties, aptamers have been considered as alternatives to antibodies. Aptasensors are considered to be an emerging strategy for the quantification of aflatoxin B1 with high selectivity and sensitivity. 
  • 830
  • 19 Oct 2020
Topic Review
Phorbas Sponges
Porifera, commonly referred to as marine sponges, are acknowledged as major producers of marine natural products (MNPs). Sponges of the genus Phorbas have attracted much attention over the years. They are widespread in all continents, and several structurally unique bioactive compounds have been identified from this species. 
  • 830
  • 30 Nov 2021
Topic Review
COVID 19 MATHEMATICS AND STATISTICS
In this approach we will summarise the the last three publications highlighting the key mathematical approach like Exponential F ( x ) to further exponential –Gaussian F ( x ) and finally the Linear Combination of Atomic Orbital ( LCAO ) ie a hybridised SP orbital overlapping to Remdesivir ( Drug ) –Covid19 approach. .Sigmoid Statistics or Logistics regression is a method to applied to Infection fatality rate ( IFR ) the most important epidemological parameters is also under consideration .
  • 829
  • 29 Oct 2020
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