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Conductive Heat Transfer in Thermal Bridges
A thermal bridge is a component of a building that is characterized by a higher thermal loss compared with its surroundings. Their accurate modeling is a key step in energy performance analysis due to the increased awareness of the importance of sustainable design. Thermal modeling in architecture and engineering is often not carried out volumetrically, thereby sacrificing accuracy for complex geometries, whereas numerical textbooks often give the finite element method in much higher generality than required, or only treat the case of uniform materials. Despite thermal modeling traditionally belonging exclusively to the engineer’s toolbox, computational and parametric design can often benefit from understanding the key steps of finite element thermal modeling, in order to inform a real-time design feedback loop. In this entry, these gaps are filled and the reader is introduced to all relevant physical and computational notions and methods necessary to understand and compute the stationary energy dissipation and thermal conductance of thermal bridges composed of materials in complex geometries. The overview is a self-contained and coherent expository, and both physically and mathematically as correct as possible, but intuitive and accessible to all audiences. Details for a typical example of an insulated I-beam thermal bridge are provided.
  • 974
  • 26 May 2022
Topic Review
Applying CADD for Neurodegenerative Diseases
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. 
  • 973
  • 07 May 2021
Topic Review
Hypoestrogenism
Hypoestrogenism, or estrogen deficiency, refers to a lower than normal level of estrogen. It is an umbrella term used to describe estrogen deficiency in various conditions. Estrogen deficiency is also associated with an increased risk of cardiovascular disease, and has been linked to diseases like urinary tract infections and osteoporosis. In women, low levels of estrogen may cause symptoms such as hot flashes, sleeping disturbances, decreased bone health, and changes in the genitourinary system. Hypoestrogenism is most commonly found in women who are postmenopausal, have primary ovarian insufficiency (POI), or are presenting with amenorrhea (absence of menstrual periods). Hypoestrogenism includes primarily genitourinary effects, including thinning of the vaginal tissue layers and an increase in vaginal pH. With normal levels of estrogen, the environment of the vagina is protected against inflammation, infections, and sexually transmitted infections. Hypoestrogenism can also occur in men, for instance due to hypogonadism. There are both hormonal and non-hormonal treatments to prevent the negative effects of low estrogen levels and improve quality of life.
  • 971
  • 09 Nov 2022
Topic Review
Methods of Preparation of Quinoxalines
Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has earned considerable attention due to its importance in the field of medicinal chemistry. The system is of extensive importance due to its comprehensive array of biological activities. Quinoxaline derivatives have been used as anticancer, anticonvulsant, anti-inflammatory, antidiabetic, antioxidant, antibacterial, anti-TB, antimalarial, antiviral, anti-HIV, and many other uses. Variously substituted quinoxalines are significant therapeutic agents in the pharmaceutical industry.
  • 970
  • 23 Nov 2023
Topic Review
Conductive Polymers and Their Properties for Flexible Devices
Flexible sensing devices have attracted significant attention for various applications, such as medical devices, environmental monitoring, and healthcare. Numerous materials have been used to fabricate flexible sensing devices and improve their sensing performance in terms of their electrical and mechanical properties. Among the studied materials, conductive polymers are promising candidates for next-generation flexible, stretchable, and wearable electronic devices because of their outstanding characteristics, such as flexibility, light weight, and non-toxicity.
  • 970
  • 23 Sep 2022
Topic Review
Bimetallic Ni-Based Catalysts CO2 Methanation
CO2 methanation has recently emerged as a process that targets the reduction in anthropogenic CO2 emissions, via the conversion of CO2 captured from point and mobile sources, as well as H2 produced from renewables into CH4. Ni, among the early transition metals, as well as Ru and Rh, among the noble metals, have been known to be among the most active methanation catalysts, with Ni being favoured due to its low cost and high natural abundance. However, insufficient low-temperature activity, low dispersion and reducibility, as well as nanoparticle sintering are some of the main drawbacks when using Ni-based catalysts. Such problems can be partly overcome via the introduction of a second transition metal (e.g., Fe, Co) or a noble metal (e.g., Ru, Rh, Pt, Pd and Re) in Ni-based catalysts. Through Ni-M alloy formation, or the intricate synergy between two adjacent metallic phases, new high-performing and low-cost methanation catalysts can be obtained.
  • 968
  • 12 May 2021
Topic Review
Glycosides
Glycosides have been identified in almost every type of plant tissue including leaves, roots, stems, and reproductive organs (i.e., flowering and fruiting bodies). The direct role of glycosides in plants is still uncertain, but it is hypothesized that glycosides were a part of the “chemodiversity” necessary for plants to survive. The addition of sugar moieties onto hydrophobic aglycones changes the overall polarity and water solubility of the aglycone. The increased polarity of the glycoside allows for detoxification, storage, and transport within the plant.
  • 967
  • 11 May 2021
Topic Review
Graphene Growth on Alloy Catalysts
Chemical vapor deposition is the most promising technique for the mass production of high-quality graphene, in which the metal substrate plays a crucial role in the catalytic decomposition of the carbon source, assisting the attachment of the active carbon species, and regulating the structure of the graphene film. Due to some drawbacks of single metal substrates, alloy substrates have gradually attracted attention owing to their complementarity in the catalytic growth of graphene.
  • 966
  • 19 Dec 2020
Topic Review
Silicon Nitride
Silicon nitride is a ceramic material with unique properties. These properties strongly encourage the use of monolithic silicon nitride and coatings as contemporary and future biomaterial for a variety of medical applications including spinal, orthopedic and dental implants, bone grafts and scaffolds, platforms for intelligent synthetic neural circuits, antibacterial and antiviral particles and coatings, optical biosensors, and nano-photonic waveguides for sophisticated medical diagnostic devices.
  • 966
  • 17 May 2021
Topic Review
Deposit Formation, Coal-Fired Rotary Kiln
The deposit-forming problem is one of the main bottlenecks restricting the yield and production benefit of iron ore pellets produced by coal-fired rotary kilns. In order to implement measures to ensure the efficient production of pellets by coal-fired rotary kilns, the mechanism and influencing factors on the deposit formation were reviewed. The pellet powder and coal ash come together to form the material base of the deposit.
  • 965
  • 08 Sep 2021
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