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Topic Review
MPM Nodal Status: Where are We at?
Due to the lack of both prospective trial and high-volume retrospective studies, the management of clinical N+ malignant pleural mesothelioma (MPM) patients remain highly debated. Node positive patients show poor survival compared with node-negative ones; thus, lymph node staging appears crucial in determining treatment strategy. Notwithstanding the improvement in pre-treatment staging and the update on lymph node classification in the 8th edition of TNM, several open controversies remain on N parameter. How should people stage suspected N+ patients? How should people treat node positive patients?  Which is the definition of “resectable patient”?  Is the site or the number the main prognostic factor for node positive patients?  The aim of the entry is to analyse the existing relevant literature on lymph node status in MPM.
  • 467
  • 09 Nov 2021
Topic Review
Chitin and Chitinase Induction in Neurodegenerative Diseases
Increased levels of Chitinases, in particular Chitotriosidase (CHIT-1) and chitinase-3-like protein 1 (CHI3L1), have been found increased in several neurodegenerative disorders. Although having important biological roles in inflammation, to date, the molecular mechanisms of Chitinase involvement in the pathogenesis of neurodegenerative disorders is not well-elucidated.
  • 467
  • 13 Apr 2023
Topic Review
Positive Affect Evoked by Music and the Arts
A positive experience in response to a piece of music or a work of art (hence ‘music/art’) has been linked to health and wellbeing outcomes but can often be reported as indescribable (ineffable), creating challenges for research. There are two simultaneously occurring classes of experience are proposed: the ‘emotion class’ of experience (ECE) and the positive ‘affect class’ of experience (PACE). ECE consists of conventional, discrete, and communicable emotions with a reasonably well-established lexicon. PACE relates to a more private world of prototypical aesthetic emotions and experiences investigated in positive psychology.
  • 467
  • 25 May 2022
Topic Review
Antiaging Potential of Peptides
Aging is a biological process that occurs under normal conditions and in several chronic degenerative diseases. Bioactive natural peptides have been shown to improve the effects of aging in cell and animal models and in clinical trials. However, few reports delve into the enormous diversity of peptides from marine organisms.
  • 466
  • 20 Dec 2021
Topic Review
Oral Microbiome Dysbiosis in Tongue Squamous Cell Carcinoma
Tongue squamous cell carcinoma(TSCC),as the most common  oral squamous cell carcinoma (OSCC), is associated with numerous risk factors. Among which oral microbiota is recognized by more and more scholars. In the oral cavity, bacteria can aggregate into colonies to form functional biofilms, and the synergistic interaction of polymicroorganisms can maintain homeostasis with the host. However, Changes in specific individual bacterial components may cause colony effects that disrupt homeostasis, which would contribute to the initiation and progression of TSCC. For instance,the change of  relative abundance of Firmicutes, Actinobacteria, Proteobacteria, Bacteroidetes, Fusobacteria and related bacteria can cause the occurrence of tongue cancer by mediating chronic inflammatory states, suppressing immune responses, synthesizing carcinogens, attenuating synthesis of anticancer agents and promoting cancer cell invasion. Therefore, the management of the  special microbiome associated with tumour microenvironments may be a promising treatment strategies for tumors in the future.
  • 466
  • 11 Oct 2022
Topic Review
Links between a Vegan Diet and Cardiovascular Diseases
The term “vegan diet” comprises a range of eating patterns that prioritize nutrient-rich foods such as fruits and vegetables, legumes, whole grains, nuts, and seeds. In comparison to omnivorous diets, which are often lower in such products, the vegan diet has been favorably connected with changes in cardiovascular disease (CVD) risk markers such as reduced body mass index (BMI) values, total serum cholesterol, serum glucose, inflammation, and blood pressure.
  • 466
  • 06 Mar 2023
Topic Review
Treatment of Enterococcus faecalis Infective Endocarditis
Today, Enterococcus faecalis is one of the main causes of infective endocarditis in the world, generally affecting an elderly and fragile population, with a high mortality rate. Enterococci are partially resistant to many commonly used antimicrobial agents such as penicillin and ampicillin, as well as high-level resistance to most cephalosporins and sometimes carbapenems, because of low-affinity penicillin-binding proteins, that lead to an unacceptable number of therapeutic failures with monotherapy. 
  • 466
  • 18 Apr 2023
Topic Review
Intelligent Physical Exercise Training
The background for this research concerns a high frequency of work-related disorders that may result from physical exposure at work being highly sedentary, repetitive–monotonous, or physically demanding. This may result in levels of physical inactivity or strenuous activity impairing health.
  • 465
  • 08 Jun 2023
Topic Review
Effect of Physical Activity/Smoking/Sleep on Telomere Length
Aging is a risk factor for several pathologies, restricting one’s health span, and promoting chronic diseases (e.g., cardiovascular and neurodegenerative diseases), as well as cancer. Telomeres are regions of repetitive DNA located at chromosomal ends. Telomere length has been inversely associated with chronological age and has been considered, for a long time, a good biomarker of aging. Several lifestyle factors have been linked with telomere shortening or maintenance. 
  • 465
  • 19 Apr 2022
Topic Review
Vitamin D and Iron on Skeletal Muscle Health
Many nutrients are essential for skeletal muscle health including vitamin D and iron. These nutrients have been well-established to play a role in improving muscular strength, muscle mass, and muscle function in various populations such as youth, athletes, and older adults. Together, muscular strength, muscle mass, and muscle function are important components that make up “skeletal muscle health”. Beyond the role that these nutrients have on skeletal muscle health, emerging literature has reported a link between vitamin D action on pro-inflammatory cytokines and mechanisms behind iron regulation, which may physiologically play a role in skeletal muscle health.
  • 465
  • 12 Jul 2022
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