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Topic Review
Brain Immunoinformatics
Breakthrough advances in informatics of the last decade have thoroughly influenced the field of immunology. In particular, the immunoinformatics of the central neural system is referred to as neuroimmunoinformatics (NII). This interdisciplinary overview on NII is addressed to bioscientists and computer scientists. We delineate the dominating trajectories and field-shaping achievements and elaborate on future directions using a bridging language and terminology. Computation, varying from linear modeling to complex deep learning approaches, fuels neuroimmunology through three core directions. Firstly, by providing big-data analysis software for high-throughput methods such as next-generation sequencing and genome-wide association studies. Secondly, by designing models for the prediction of protein morphology, functions, and protein-protein interactions. Finally, NII boosts the output of quantitative pathology by enabling the automatization of tedious processes such as cell counting, tracing, and arbor analysis. Deep sequencing classifies microglia in “sensotypes” to accurately describe the versatility of immune responses to physiological and pathological challenges, as well as to experimental conditions such as xenografting and organoids. NII opts to individualize treatment strategies, personalize disease prognosis and treatment response.   
  • 571
  • 28 Mar 2022
Topic Review
Skin Wound Management
Etiologically, the skin wounds could be classified as acute, chronic, or malignant wounds. In general, an ordered and normal wound healing process happens after acute wounds. On the contrary, chronic wounds are characterized by prolonged inflammatory phase, sustained infection, and the generation of drug-resistance microbial biofilms, leading to an impaired wound healing cascade.
  • 570
  • 29 Jun 2021
Topic Review
Carcinogenic Effects of Formaldehyde Occupational Exposure
Formaldehyde is a chemical compound present in many working activities and indoor workplaces. Occupational exposure occurs primarily by inhaling airborne formaldehyde, but it can also be absorbed through the skin or ingested. Formaldehyde, classified as a carcinogen in 2004, as of today is widely used in many work activities. The evidence of correlation between formaldehyde occupational exposure and the occurrence of cancer is limited. Recent evidence suggest that its carcinogenicity should be re-evaluated, especially in view of current exposure limits.
  • 571
  • 27 Jan 2022
Topic Review
Electrochemical Biosensors for Genetically Modified Crops Detection
Food safety issues are directly related to people's quality of life, so there is a need to develop efficient and reliable food contaminants’ detection devices to ensure the safety and quality of food. Electrochemical biosensors have the significant advantages of miniaturization, low cost, high sensitivity, high selectivity, rapid detection, and low detection limits using small amounts of samples, which are expected to enable on-site analysis of food products.
  • 569
  • 21 Nov 2022
Topic Review
MMSE and MoCA
Objective: Primary care clinicians in Asia employed the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to aid dementia diagnosis post-stroke. Recent studies questioned their clinical utility in stroke settings for relying on verbal abilities and education level, as well as lack of consideration for aphasia and neglect. We aimed to review the clinical utility of the MMSE and MoCA for stroke patients in Asia and provide recommendations for clinical practice.
  • 568
  • 02 Nov 2021
Topic Review
Older Adults with Cancer and COVID-19
Older adults with cancer are amongst the most vulnerable population to be negatively impacted by COVID-19 due to their likelihood of comorbidities and compromised immune status. Considering the longevity of the pandemic, understanding the subjective perceptions and psychosocial concerns of this population may help ameliorate the psychological aftermath.
  • 567
  • 23 Feb 2022
Topic Review
Intimate Partner Violence during COVID-19
Domestic violence abuse (DVA) is a widespread public health problemthat includes different kinds of abuse, such as that upon elderly individuals and children in the family, while intimate partner violence (IPV) refers to violence by a current or former spouse or partner in an intimate relationship with the victim. IPV can be physical, psychological, sexual, or economic and can have negative health consequences on the victim. Social isolation is considered one of the main risk factors leading to intimate partner violence episodes; this evidence also emerged during the application of stay-at-home policies to contain the COVID-19 pandemic.
  • 567
  • 17 Jun 2021
Topic Review
COVID-19 Pandemic in Lifestyle
The spread of the COVID-19 (SARS-CoV-2) pandemic worldwide has forced countries to handle the crisis in different ways, declaring a national state of alarm and establishing a mandatory home lockdown. The COVID-19 infection represents a strong stress stimulus, which can induce high levels of perceived risk, fear, and anger, while forced quarantine at home may provoke an experience of boredom and loneliness, eliciting negative mental and behavioural responses in people. Furthermore, the more time people remain at home, the more intense the resulting mental, emotional and lifestyle problems.
  • 567
  • 08 Oct 2021
Topic Review
Urological Safety and COVID-19 Vaccinations
During the COVID-19 pandemic, elective surgeries were suspended for many months, and only high-risk oncological cases were addressed, although an ambulatory follow-up and management of benign conditions, which can cause lower urinary tract symptoms (LUTS), were essential. In neurologic patients, for example, LUTS have a great impact on quality of life and social life, and their clinical conditions can seriously worsen if not properly addressed.
  • 566
  • 24 Nov 2022
Topic Review
Internet Use for Older Adults during COVID-19 Pandemic
Older adults were advised to avoid social activities during the outbreak of COVID-19. Consequently, they no longer received the social and emotional support they had gained from such activities. Internet use might be a solution to remedy the situation. The research revealed that Internet use for communication purposes seems to be associated with better mental health in older adults during the COVID-19 pandemic.
  • 566
  • 06 Apr 2022
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