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Buomprisco, G. Carcinogenic Effects of Formaldehyde Occupational Exposure. Encyclopedia. Available online: https://encyclopedia.pub/entry/18844 (accessed on 21 July 2024).
Buomprisco G. Carcinogenic Effects of Formaldehyde Occupational Exposure. Encyclopedia. Available at: https://encyclopedia.pub/entry/18844. Accessed July 21, 2024.
Buomprisco, Giuseppe. "Carcinogenic Effects of Formaldehyde Occupational Exposure" Encyclopedia, https://encyclopedia.pub/entry/18844 (accessed July 21, 2024).
Buomprisco, G. (2022, January 26). Carcinogenic Effects of Formaldehyde Occupational Exposure. In Encyclopedia. https://encyclopedia.pub/entry/18844
Buomprisco, Giuseppe. "Carcinogenic Effects of Formaldehyde Occupational Exposure." Encyclopedia. Web. 26 January, 2022.
Carcinogenic Effects of Formaldehyde Occupational Exposure
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This entry is adapted from the peer-reviewed paper 10.3390/cancers14010165

Formaldehyde is a chemical compound present in many working activities and indoor workplaces. Occupational exposure occurs primarily by inhaling airborne formaldehyde, but it can also be absorbed through the skin or ingested. Formaldehyde, classified as a carcinogen in 2004, as of today is widely used in many work activities. The evidence of correlation between formaldehyde occupational exposure and the occurrence of cancer is limited. Recent evidence suggest that its carcinogenicity should be re-evaluated, especially in view of current exposure limits.

formaldehyde carcinogenicity occupational exposure cancer risk

1. Introduction

Formaldehyde (FA) is a chemical compound naturally occurring in the atmosphere, in some foods, and in the organisms of mammals as a product of oxidative metabolism and, thus, is considered a ubiquitous pollutant. In addition to these sources, FA can be released in the environment through combustion processes or by degradation of some hydrocarbons such as methane. Besides, due to its chemical–physical characteristics, FA is widely applied in many productive processes, such as the construction materials industry, the chemical industry (resins, paintings, etc.), the wood-processing and furniture industry, the food industry, biomedical laboratories, gross anatomy rooms, handicrafts, etc. [1]. Consequently, many types of occupational activities determine FA exposure. Driscoll et al. [2] conducted a study based on data obtained from the Australian Workplace Exposures Study about the prevalence and patterns of exposure to 38 known or suspected carcinogens, including FA, among the Australian working population. As a result, 2.5% of the workers were likely to have been exposed to FA. The main working activities that exposed them to this chemical were the processing of chipboards or plywood panels for carpentry, building maintenance, and sanding before painting. The other workers most exposed were firefighters [3][4][5], healthcare workers [6], and beauticians. FA has also been detected in restaurants [7][8] when grilling dishes and adding sauces, in copy shops [9][10], in gardening [11], in the agri-food sector [12][13], in veterinary clinics, in embalming laboratories, in industrial launderings, etc. Besides, FA is frequently found in building environments, posing at potential risk of exposure to all indoor workers [14][15][16][17][18][19].
Exposure occurs primarily by inhaling airborne FA, but it can also be absorbed through the skin or ingested. The International Agency for Research on Cancer (IARC) in 2004 concluded that there was sufficient evidence of the carcinogenicity of FA for humans to reclassify FA from Group 2A (probably carcinogenic to humans) to Group 1 (carcinogenic to humans) [20]. In the subsequent monograph n. 100 of 2012, in summary, the IARC confirmed that there was sufficient epidemiological evidence that FA causes tumors of the nasopharynx, insufficient evidence of a causal relationship with leukemia, and limited epidemiological evidence for nasal sinus cancer [21]. EU Regulation 2015/491 also imposed the reclassification of FA from suspected carcinogen to carcinogen for humans in category 1B (i.e., it can cause cancer) on the basis of sufficient evidence both in humans [22][23] and in experimental animals [24][25]. However, all the scientific evidence that led to these classifications date back to before 2005. Besides, most of the studies on the relationship between FA and cancer were in vitro experiments demonstrated the effects on culture cells. Researchers have found many cellular damages, like DNA and RNA alterations [26][27], the onset of DNA–protein crosslinks, changes in p53 protein expression [28], and histone modifications [29]. On the other hand, epidemiological studies have not been able to confirm this association. In addition, several previous reviews investigated the relationship between occupational FA exposure and the onset of specific cancers, often obtaining conflicting conclusions [30][31][32][33][34].

2. Carcinogenic Effects of Formaldehyde Occupational Exposure

Most of the studies dealt with occupational settings, characterized by a deliberate use of FA as a component of the production cycle. Those were mainly represented by chemical industries dedicated to the production of plastics, fiberglass, paints, etc.; it is reasonable to imagine that in such contexts the levels of exposure to FA were particularly high. Three studies were carried out in textile-/garment-producing plants, where FA is used to give resistance to the folds of clothing fabrics and for the processing of leathers. Another sector where this substance is widely used is that of woodworking and furniture making. In fact, FA, together with resins, gives strength and resistance to chipboard panels. FA is also widely used in the medical field: in the operating room it was used to disinfect instruments because of its high antibacterial power, and even today, it is used to avoid the deterioration of human tissues that must undergo histopathological analyses. Despite that, very few studies concerned the health sector, or the agri-food industry, where FA is used as a preservative. That is quite surprising, considering that there is much research about the occupational exposure to FA in pathological anatomy settings and sector rooms [35][36][37] that stress the needing for adequate preventive measures for workers [38].

Although the genotoxicity and immunotoxicity of FA is well known and has been demonstrated by several studies regarding its influence on DNA and pro-oxidative effects on cells [28][39][40][41][42][43][44][45][46], the evidence from human studies and diagnosed cancers is much less consistent [47]. Most of the studies focus on upper-airway neoplasms (ICD-10 codes: C10–C14 and C30–C33). In fact, the main way of entry of this substance into the body is by inhalation. Five studies explored the relationship between FA occupational exposure and the onset of lung cancer (ICD-10 code: C34). Their findings contrasted with each other: some did not provide evidence of a carcinogenic effect on the lungs [48][49][50], whereas others found a correlation [51][52]. These last studies, however, were performed on a very small sample and present several limitations (e.g., self-reported data on exposure levels). A recent meta-analysis [31] concluded no significant increase in the risk of lung cancer, even considering only groups of highly exposed workers. The small study sample of the study by Checkoway et al. about lung cancer was also checked for thyroid cancer, with some relationships found but with the same, considerable, limitations [53]. In 2012, the IARC affirmed that there was strong but insufficient evidence of a causal relationship with leukemia. Two studies included regarded the relationship between FA exposure and lympho-hematopoietic cancers (ICD-10 codes: C81–C96), but no association was observed for all leukemias [54], except for a small and weak association with non-Hodgkin lymphoma [55] and myeloid leukemia [56]. This is consistent with the results of other previous studies [30][33]. Five of the included publications evaluated the effects of FA occupational exposure on the onset of any kind of cancer. These were large cohort studies, carried out in Europe and the USA in industrial contexts, and almost all concluded no positive association with FA exposure and the mortality from any cancer, and very limited evidence with NPC and leukemia [57][58][59][60][54]. The most recent research included, published in 2018, was a multicenter study about FA and meningioma. Meningiomas are tumors that develop from the meninges, tissues that surround the outside of the brain and account for about 30% of brain tumors. Although benign, they are dangerous because dysphagia, dysarthria, ocular motility disorders, and facial numbness can occur. Intracranial hypertension, focal seizures, lack of strength, and balance and gait disturbances may also sometimes occur. The study concluded that FA did not provoke excess risks of meningioma [61].

References

  1. Cammalleri, V.; Pocino, R.N.; Marotta, D.; Protano, C.; Sinibaldi, F.; Simonazzi, S.; Petyx, M.; Iavicoli, S.; Vitali, M. Occupational scenarios and exposure assessment to formaldehyde: A systematic review. Indoor Air, 2021, in press.
  2. Driscoll, T.R.; Carey, R.N.; Peters, S.; Glass, D.C.; Benke, G.; Reid, A.; Fritschi, L. The Australian Work Exposures Study: Prevalence of Occupational Exposure to Formaldehyde. Ann. Occup. Hyg. 2016, 60, 132–138.
  3. Reisen, F.; Brown, S.K. Australian firefighters’ exposure to air toxics during bushfire burns of autumn 2005 and 2006. Environ. Int. 2009, 35, 342–352.
  4. Laitinen, J.; Makela, M.; Mikkola, J.; Huttu, I. Fire fighting trainers’ exposure to carcinogenic agents in smoke diving simulators. Toxicol. Lett. 2010, 192, 61–65.
  5. Jankovic, J.; Jones, W.; Burkhart, J.; Noonan, G. Environmental study of firefighters. Ann. Occup. Hyg. 1991, 35, 581–602.
  6. Vecchio, D.; Sasco, A.J.; Cann, C.I. Occupational risk in health care and research. Am. J. Ind. Med. 2003, 43, 369–397.
  7. Que, D.E.; Chao, H.R.; Hsu, Y.C.; Cui, K.; Chen, S.; Tayo, L.L.; Arcega, R.D.; Tsai, Y.I.; Lu, I.C.; Wang, L.C.; et al. Emission of carbonyl compounds from cooking oil fumes in the night market areas. Aerosol. Air Qual. Res. 2019, 19, 1566–1578.
  8. Jung, J.H.; Youn, S.U.; Kwon, E.; Im, S.; Akiyama, Y.; Arashidani, K.; Yang, W. Emission rates of air pollutants from portable gas ranges and nitrogen dioxide exposure assessment in restaurants. J. UOEH 2009, 31, 13–22.
  9. Su, M.; Sun, R.; Zhang, X.; Wang, S.; Zhang, P.; Yuan, Z.; Liu, C.; Wang, Q. Assessment of the inhalation risks associated with working in printing rooms: A study on the staff of eight printing rooms in Beijing, China. Environ. Sci. Pollut. Res. Int. 2018, 25, 17137–17143.
  10. Vicente, E.D.; Ribeiro, J.P.; Custódio, D.; Alves, C.A. Assessment of the indoor air quality in copy centers at Aveiro, Portugal. Air Qual. Atmos. Health 2017, 10, 117–127.
  11. Baldauf, R.; Fortune, C.; Weinstein, J.; Wheeler, M.; Blanchard, F. Air contaminant exposures during the operation of lawn and garden equipment. J. Expo. Sci. Environ. Epidemiol. 2006, 16, 362–370.
  12. Voorhees, J.M.; Barnes, M.E. Airborne Formaldehyde Levels during Simulated Formalin Egg Treatments in Vertical-Flow Tray Incubators at a Production Fish Hatchery. J. Agric. Saf. Health 2016, 22, 199–207.
  13. Doane, M.; Sarenbo, S. Exposure of farm laborers and dairy cattle to formaldehyde from footbath use at a dairy farm in New York State. Sci. Total Environ. 2014, 487, 65–71.
  14. Kim, W.J.; Terada, N.; Nomura, T.; Takahashi, R.; Lee, S.D.; Park, J.H.; Konno, A. Effect of formaldehyde on the expression of adhesion molecules in nasal microvascular endothelial cells: The role of formaldehyde in the pathogenesis of sick building syndrome. Clin. Exp. Allergy 2002, 32, 287–295.
  15. Ho, S.S.H.; Cheng, Y.; Bai, Y.; Ho, K.F.; Dai, W.T.; Cao, J.J.; Lee, S.C.; Huang, Y.; Ip, H.S.S.; Deng, W.J.; et al. Risk assessment of indoor formaldehyde and other carbonyls in campus environments in northwestern China. Aerosol. Air Qual. Res. 2016, 16, 1967–1980.
  16. Pośniak, M.; Makhniashvili, I.; Koziel, E. Volatile organic compounds in the indoor air of Warsaw office buildings. Indoor Built Environ. 2005, 14, 269–275.
  17. Salonen, H.J.; Pasanen, A.L.; Lappalainen, S.K.; Riuttala, H.M.; Tuomi, T.M.; Pasanen, P.O.; Back, B.C.; Reijula, K.E. Airborne concentrations of volatile organic compounds, formaldehyde and ammonia in Finnish office buildings with suspected indoor air problems. J. Occup. Environ. Hyg. 2009, 6, 200–209.
  18. Hui, P.S.; Mui, K.W.; Wong, L.T. Influence of indoor air quality (IAQ) objectives on air-conditioned offices in Hong Kong. Environ. Monit. Assess. 2008, 144, 315–322.
  19. Kaden, D.A.; Mandin, C.; Nielsen, G.D.; Wolkoff, P. Formaldehyde. In WHO Guidelines for Indoor Air Quality: Selected Pollutants; World Health Organization: Geneva, Switzerland, 2010; Available online: https://www.ncbi.nlm.nih.gov/books/NBK138711 (accessed on 10 September 2021).
  20. International Agency for Research on Cancer (IARC). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Formaldehyde, 2-Butoxyethanol and 1-Tert-Butoxypropan-2-ol. 88; International Agency for Research on Cancer: Lyon, France, 2006.
  21. International Agency for Research on Cancer (IARC). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Chemical Agents and Related Occupations, Vol 100 F, A Review of Human Carcinogen; WHO, International Agency for Research on Cancer: Lyon, France, 2012.
  22. Cogliano, V.J.; Grosse, Y.; Baan, R.A.; Straif, K.; Secretan, M.B.; El Ghissassi, F. Working Group for Volume 88. Meeting report: Summary of IARC monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Environ. Health Perspect. 2005, 113, 1205–1208.
  23. Blair, A.; Saracci, R.; Stewart, P.A.; Hayes, R.B.; Shy, C. Epidemiologic evidence on the relationship between formaldehyde exposure and cancer. Scand. J. Work Environ. Health 1990, 16, 381–393.
  24. Kerns, W.D.; Pavkov, K.L.; Donofrio, D.J.; Gralla, E.J.; Swenberg, J.A. Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res. 1983, 43, 4382–4392.
  25. Swenberg, J.A.; Kerns, W.D.; Mitchell, R.I.; Gralla, E.J.; Pavkov, K.L. Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapor. Cancer Res. 1980, 40, 3398–3402.
  26. Ye, X.; Yan, W.; Xie, H.; Zhao, M.; Ying, C. Cytogenetic analysis of nasal mucosa cells and lymphocytes from high-level long-term formaldehyde exposed workers and low-level short-term exposed waiters. Mutat. Res. 2005, 588, 22–27.
  27. Gonzalez-Rivera, J.C.; Sherman, M.W.; Wang, D.S.; Chuvalo-Abraham, J.C.L.; Hildebrandt Ruiz, L.; Contreras, L.M. RNA oxidation in chromatin modification and DNA-damage response following exposure to formaldehyde. Sci. Rep. 2020, 10.
  28. Shaham, J.; Bomstein, Y.; Gurvich, R.; Rashkovsky, M.; Kaufman, Z. DNA-protein crosslinks and p53 protein expression in relation to occupational exposure to formaldehyde. Occup. Environ. Med. 2003, 60, 403–409.
  29. Lu, K.; Boysen, G.; Gao, L.; Collins, L.B.; Swenberg, J.A. Formaldehyde-induced histone modifications in vitro. Chem. Res. Toxicol. 2008, 21, 1586–1593.
  30. Catalani, S.; Donato, F.; Madeo, E.; Apostoli, P.; De Palma, G.; Pira, E.; Mundt, K.A.; Boffetta, P. Occupational exposure to formaldehyde and risk of non-hodgkin lymphoma: A meta-analysis. BMC Cancer 2019, 19, 1245.
  31. Kwak, K.; Paek, D.; Park, J.T. Occupational exposure to formaldehyde and risk of lung cancer: A systematic review and meta-analysis. Am. J. Ind. Med. 2020, 63, 312–327.
  32. Collins, J.J.; Esmen, N.A.; Hall, T.A. A review and meta-analysis of formaldehyde exposure and pancreatic cancer. Am. J. Ind Med. 2001, 39, 336–345.
  33. Checkoway, H.; Boffetta, P.; Mundt, D.J.; Mundt, K.A. Critical review and synthesis of the epidemiologic evidence on formaldehyde exposure and risk of leukemia and other lymphohematopoietic malignancies. Cancer Causes Control 2012, 23, 1747–1766.
  34. Kang, D.S.; Kim, H.S.; Jung, J.H.; Lee, C.M.; Ahn, Y.S.; Seo, Y.R. Formaldehyde exposure and leukemia risk: A comprehensive review and network-based toxicogenomic approach. Genes Environ. 2021, 43, 13.
  35. Aung, W.Y.; Sakamoto, H.; Sato, A.; Yi, E.E.; Thein, Z.L.; New, M.S.; Shein, N.; Linn, H.; Uchiyama, S.; Kunugita, N.; et al. Indoor Formaldehyde Concentration, Personal Formaldehyde Exposure and Clinical Symptoms during Anatomy Dissection Sessions, University of Medicine 1, Yangon. Int. J. Environ. Res. Public Health 2021, 18, 712.
  36. Waschke, J.; Bergmann, M.; Bräuer, L.; Brenner, E.; Buchhorn, A.; Deutsch, A.; Dokter, M.; Egu, D.T.; Ergün, S.; Fassnacht, U.; et al. Recommendations of the working group of the Anatomische Gesellschaft on reduction of formaldehyde exposure in anatomical curricula and institutes. Ann. Anat. 2019, 221, 179–185.
  37. Jalali, M.; Moghadam, S.R.; Baziar, M.; Hesam, G.; Moradpour, Z.; Zakeri, H.R. Occupational exposure to formaldehyde, lifetime cancer probability, and hazard quotient in pathology lab employees in Iran: A quantitative risk assessment. Environ. Sci. Pollut. Res. Int. 2021, 28, 1878–1888.
  38. Bhat, D.; Chittoor, H.; Murugesh, P.; Basavanna, P.N.; Doddaiah, S. Estimation of occupational formaldehyde exposure in cadaver dissection laboratory and its implications. Anat. Cell Biol. 2019, 52, 419–425.
  39. Bouraoui, S.; Mougou, S.; Brahem, A.; Tabka, F.; Ben Khelifa, H.; Harrabi, I.; Mrizek, N.; Elghezal, H.; Saad, A. A combination of micronucleus assay and fluorescence in situ hybridization analysis to evaluate the genotoxicity of formaldehyde. Arch. Environ. Contam. Toxicol. 2013, 64, 337–344.
  40. Teng, S.; Beard, K.; Pourahmad, J.; Moridani, M.; Easson, E.; Poon, R.; O’Brien, P.J. The formaldehyde metabolic detoxified on enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes. Chem. Biol. Interact. 2001, 130–132, 285–296.
  41. Saito, Y.; Nishio, K.; Yoshida, Y.; Niki, E. Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species. Toxicology 2005, 210, 235–245.
  42. Jiang, S.; Yu, L.; Cheng, J.; Leng, S.; Dai, Y.; Zhang, Y.; Niu, Y.; Yan, H.; Qu, W.; Zhang, C.; et al. Genomic damages in peripheral blood lymphocytes and association with polymorphisms of three glutathione S-transferases in workers exposed to formaldehyde. Mutat. Res. 2010, 695, 9–15.
  43. Aydin, S.; Canpinar, H.; Ündeğer, Ü.; Güç, D.; Çolakoğlu, M.; Kars, A.; Başaran, N. Assessment of immunotoxicity and genotoxicity in workers exposed to low concentrations of formaldehyde. Arch. Toxicol. 2013, 87, 145–153.
  44. Viegas, S.; Ladeira, C.; Nunes, C.; Malta-Vacas, J.; Gomes, M.; Brito, M.; Mendonca, P.; Prista, J. Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production. J. Occup. Med. Toxicol. 2010, 5, 25.
  45. Costa, S.; Coelho, P.; Costa, C.; Silva, S.; Mayan, O.; Santos, L.S.; Gaspar, J.; Teixeira, J.P. Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde. Toxicology 2008, 252, 40–48.
  46. Burgaz, S.; Erdem, O.; Cakmak, G.; Erdem, N.; Karakaya, A.; Karakaya, A.E. Cytogenetic analysis of buccal cells from shoe-workers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde. Biomarkers 2002, 7, 151–161.
  47. Duhayon, S.; Hoet, P.; Van Maele-Fabry, G.; Lison, D. Carcinogenic potential of formaldehyde in occupational settings: A critical assessment and possible impact on occupational exposure levels. Int. Arch. Occup. Environ. Health 2008, 81, 695–710.
  48. Kjaerheim, K.; Boffetta, P.; Hansen, J.; Cherrie, J.; Chang-Claude, J.; Eilber, U.; Ferro, G.; Guldner, K.; Olsen, J.H.; Plato, N.; et al. Lung cancer among rock and slag wool production workers. Epidemiology 2002, 13, 445–453.
  49. Siew, S.S.; Kauppinen, T.; Kyyrönen, P.; Heikkilä, P.; Pukkala, E. Occupational exposure to wood dust and formaldehyde and risk of nasal, nasopharyngeal, and lung cancer among Finnish men. Cancer Manag. Res. 2012, 4, 223–232.
  50. Mahboubi, A.; Koushik, A.; Siemiatycki, J.; Lavoué, J.; Rousseau, M.C. Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case-control studies. Scand. J. Work Environ. Health 2013, 39, 401–410.
  51. De Stefani, E.D.; Boffetta, P.; Brennan, P.; Deneo-Pellegrini, H.; Ronco, A.; Gutiérrez, L.P. Occupational Exposures and Risk of Adenocarcinoma of the Lung in Uruguay. Cancer Causes Control 2005, 16, 851–856.
  52. Checkoway, H.; Ray, R.M.; Lundin, J.I.; Astrakianakis, G.; Seixas, N.S.; Camp, J.E.; Wernli, K.J.; Fitzgibbons, E.D.; Li, W.; Feng, Z.; et al. Lung cancer and occupational exposures other than cotton dust and endotoxin among women textile workers in Shanghai, China. Occup. Environ. Med. 2011, 68, 425–429.
  53. Wong, E.Y.; Ray, R.; Gao, D.L.; Wernli, K.J.; Li, W.; Fitzgibbons, E.D.; Feng, Z.; Thomas, D.B.; Checkoway, H. Reproductive history, occupational exposures, and thyroid cancer risk among women textile workers in Shanghai, China. Int. Arch. Occup. Environ. Health 2006, 79, 251–258.
  54. Pira, E.; Romano, C.; Verga, F.; La Vecchia, C. Mortality from lymphohematopoietic neoplasms and other causes in a cohort of laminated plastic workers exposed to formaldehyde. Cancer Causes Control 2014, 25, 1343–1349.
  55. Wang, R.; Zhang, Y.; Lan, Q.; Holford, T.R.; Leaderer, B.; Zahm, S.H.; Boyle, P.; Dosemeci, M.; Rothman, N.; Zhu, Y.; et al. Occupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut women. Am. J. Epidemiol. 2009, 169, 176–185.
  56. Hauptmann, M.; Stewart, P.A.; Lubin, J.H.; Beane Freeman, L.E.; Hornung, R.W.; Herrick, R.F.; Hoover, R.N.; Fraumeni, J.F., Jr.; Blair, A.; Hayes, R.B. Mortality from lymphohematopoietic malignancies and brain cancer among embalmers exposed to formaldehyde. J. Natl. Cancer Inst. 2009, 101, 1696–1708.
  57. Pinkerton, L.E.; Hein, M.J.; Stayner, L.T. Mortality among a cohort of garment workers exposed to formaldehyde: An update. Occup. Environ. Med. 2004, 61, 193–200.
  58. Meyers, A.R.; Pinkerton, L.E.; Hein, M.J. Cohort mortality study of garment industry workers exposed to formaldehyde: Update and internal comparisons. Am. J. Ind. Med. 2013, 56, 1027–1039.
  59. Beane Freeman, L.E.; Blair, A.; Lubin, J.H.; Stewart, P.A.; Hayes, R.B.; Hoover, R.N.; Hauptmann, M. Mortality from solid tumors among workers in formaldehyde industries: An update of the NCI cohort. Am. J. Ind. Med. 2013, 56, 1015–1026.
  60. Coggon, D.; Ntani, G.; Harris, E.C.; Palmer, K.T. Upper airway cancer, myeloid leukemia, and other cancers in a cohort of British chemical workers exposed to formaldehyde. Am. J. Epidemiol. 2014, 179, 1301–1311.
  61. McElvenny, D.M.; van Tongeren, M.; Turner, M.C.; Benke, G.; Figuerola, J.; Fleming, S.; Hours, M.; Kincl, L.; Krewski, D.; McLean, D.; et al. The INTEROCC case-control study: Risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents. Occup. Environ. Med. 2018, 75, 12–22.
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