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All Topic Review Biography
Topic Review
Uncontrolled Chronic Rhinosinusitis with Nasal Polyps
Chronic rhinosinusitis (CRS) is recognized as a heterogeneous disease with a wide range of clinical features, resulting in significant morbidity and cost to the healthcare system. The phenotypic classification is determined by the presence or absence of nasal polyps and comorbidities, the endotype classification has been established based on molecular biomarkers or specific mechanisms.
  • 246
  • 09 Jun 2023
Topic Review
Epithelial–Mesenchymal Transition in Salivary Adenoid Cystic Carcinoma
Salivary adenoid cystic carcinoma (SACC) is considered the second most frequent malignant salivary gland neoplasm and exhibits a controversial and poorly understood biological behavior, characterized by slow and indolent growth. SACC typically arises from the submandibular gland and minor salivary glands, while its occurrence in the parotid gland is relatively rare. SACC has an incidence rate of approximately 4.5 cases per million individuals and constitutes 10% of all salivary gland tumors (SGTs). This type of cancer exhibits three distinct histological growth patterns, namely cribriform, tubular, and solid patterns. Among these patterns, the solid pattern represents the most aggressive form of SACC with an increased risk of metastasis, resulting in shorter disease-specific survival.
  • 189
  • 30 May 2023
Topic Review
Hearing Rehabilitation in Vestibular Schwannoma
The most common complaint among patients with vestibular schwannoma (VS) is hearing loss. This significantly affects the quality of life before, during, and after treatment for patients with VS. Untreated hearing loss in VS patients may even lead to depression and feelings of social isolation. A variety of devices are available for hearing rehabilitation for patients with vestibular schwannoma. 
  • 248
  • 30 May 2023
Topic Review
Molecules Used to Prevent Nasal Polyp Recurrences
Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, which is typically characterized by a Type 2 inflammatory reaction, comorbidities and high rates of nasal polyp recurrence, causing severe impact on quality of life. Nasal polyp recurrence rates, defined as the number of patients undergoing revision endoscopic sinus surgery, are 20% within a 5 year period after surgery. The cornerstone of CRSwNP management consists of anti-inflammatory treatment with local corticosteroids. The therapeutic strategies used to prevent nasal polyp recurrence (NPR) after surgical treatment are discussed. 
  • 255
  • 22 May 2023
Topic Review
Atypical Skull-Base Osteomyelitis
Atypical skull-base osteomyelitis is a rare but fatal disease that usually involves infection of the ethmoid, sphenoid, occipital, or temporal bones that form the skull base. Unlike typical (so-called otogenic), atypical skull-base osteomyelitis has no otogenic cause. Instead, some authors call atypical skull-base osteomyelitis sinonasal, since the infection most often originates from the nose and paranasal sinuses. 
  • 341
  • 09 May 2023
Topic Review
Noise-Induced Hearing Loss
Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural hearing loss, after age-related hearing loss, and affects approximately 5% of the world’s population. NIHL is associated with substantial physical, mental, social, and economic impacts at the patient and societal levels. Stress and social isolation in patients’ workplace and personal lives contribute to quality-of-life decrements which may often go undetected. 
  • 496
  • 11 Apr 2023
Topic Review
Transoral Robotic Surgery: Applications in HNC
Minimally invasive surgery is a growing field in surgical oncology. After acquiring its first Food and Drug Administration approval in 2009 for T1–T2 malignancies of the oral cavity, oropharynx, and larynx, transoral robotic surgery (TORS) has gained popularity thanks to its wristed instruments and magnified three-dimensional view, enhancing surgical comfort in remote-access areas. Its indications are expanding in the treatment of head and neck cancer, i.e., resection of tumors of the larynx, hypopharynx, or parapharyngeal space. Head and neck cancer (HNC) incidence has increased, ranking eighth among the most common cancers worldwide in 2020 with approximately 900,000 cases yearly. Following a similar trend, head and neck surgeons in Australia and New Zealand have a TORS adoption rate of 43.6%. The main indications for TORS in all these countries are lateral oropharyngectomy, base-of-tongue mucosectomy, and surgery for obstructive sleep apnea.
  • 388
  • 30 Mar 2023
Topic Review
Potential Therapies for Obstructive Sleep Apnea
Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent hypoxia (IH) during sleep due to recurrent upper airway obstruction. The derived oxidative stress (OS) leads to complications that do not only concern the sleep-wake rhythm but also systemic dysfunctions.
  • 238
  • 29 Mar 2023
Topic Review
Voice Tremor and Botulinum Neurotoxin Therapy
Voice tremor is a common, yet debilitating symptom for patients suffering from a number of tremor-associated disorders. The key to targeting effective treatments for voice tremor requires a fundamental understanding of the pathophysiology that underpins the tremor mechanism and accurate identification of the disease in affected patients. An updated review of the literature detailing the current understanding of voice tremor (with or without essential tremor), its accurate diagnosis and targeted treatment options was conducted, with a specific focus on the role of botulinum neurotoxin. Judicious patient selection, following detailed characterisation of voice tremor qualities, is essential to optimising treatment outcomes for botulinum neurotoxin therapy, as well as other targeted therapies. Further focused investigation is required to characterise the response to targeted treatment in voice tremor patients and to guide the development of innovative treatment options.
  • 490
  • 09 Jan 2023
Topic Review
Swallow Detection with Acoustics and Accelerometric-Based Wearable Technology
Swallowing disorders, especially dysphagia, might lead to malnutrition and dehydration and could potentially lead to fatal aspiration. Benchmark swallowing assessments, such as videofluoroscopy or endoscopy, are expensive and invasive. Wearable technologies using acoustics and accelerometric sensors could offer opportunities for accessible and home-based long-term assessment. Identifying valid swallow events is the first step before enabling the technology for clinical applications. 
  • 458
  • 09 Jan 2023
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