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Topic Review
Mycobacterium avium ssp. paratuberculosis and Crohn’s Disease
Mycobacterium avium ssp. paratuberculosis (MAP) is the cause of Johne’s disease (JD), which is a chronic infectious gastrointestinal disease of ruminants and is often fatal. In humans, MAP has been associated with Crohn’s disease (CD) for over a century, without conclusive evidence of pathogenicity. Numerous researchers have contributed to the subject, but there is still a need for evidence of the causation of CD by MAP.
  • 121
  • 07 Mar 2024
Topic Review
Mycoplasma bovis Infections
Mycoplasma bovis is a cause of bronchopneumonia, mastitis and arthritis but may also affect other main organs in cattle such us the eye, ear or brain. M. bovis infections are responsible for substantial economic health and welfare problems worldwide. M. bovis has spread worldwide, including to countries for a long time considered free of the pathogen.
  • 291
  • 15 Nov 2022
Topic Review
Neisseria gonorrhoeae Antimicrobial Resistance
The growing threat of antibiotic-resistant Neisseria gonorrhoeae, which causes gonorrhea, presents a current public health challenge. Over the years, the pathogen has developed resistance to different antibiotics, leaving few effective treatment options. High-level resistance to key drugs, including ceftriaxone, has become a concerning reality.
  • 107
  • 05 Jan 2024
Topic Review
P. falciparum Invasion and Erythrocyte Aging
Plasmodium parasites need to find red blood cells (RBCs) that, on the one hand, expose receptors for the pathogen ligands and, on the other hand, maintain the right geometry to facilitate merozoite attachment and entry into the red blood cell. Both characteristics change with the maturation of erythrocytes. 
  • 51
  • 28 Feb 2024
Topic Review
Rocahepevirus ratti as Cause of Acute Hepatitis Worldwide
The hepatitis E virus (HEV) is a widespread human infection that causes mainly acute infection and can evolve to a chronic manifestation in immunocompromised individuals. In addition to the common strains of hepatitis E virus (HEV-A), known as Paslahepevirus balayani, pathogenic to humans, a genetically highly divergent rat origin hepevirus (RHEV) can cause hepatitis possessing a potential risk of cross-species infection and zoonotic transmission. Rocahepevirus ratti, formerly known as Orthohepevirus C, is a single-stranded RNA virus, recently reassigned to Rocahepevirus genus in the Hepeviridae family, including genotypes C1 and C2.
  • 141
  • 22 Dec 2023
Topic Review
7-Methyljuglone in Tuberculosis Treatment
7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of Euclea natalensis A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for the highly communicable disease tuberculosis (TB), owing to its effective antimycobacterial activity against Mycobacterium tuberculosis. 
  • 80
  • 01 Mar 2024
Topic Review
A Defective Viral Particle Approach to COVID-19
Defective interfering particles, which arise naturally and interfere with viruses, have long inspired the idea that they might be adapted to treat viral diseases. Here, we explore how such defective interfering particles and other therapeutic nanoparticles might be designed and constructed to interfere with SARS-CoV-2.
  • 448
  • 28 Jan 2022
Topic Review
Acute Infectious Gastroenteritis
Acute infectious gastroenteritis (AGE) is defined as a diarrhoeal disease of rapid onset presenting with the incidence of three or more soft or liquid stools, or three bouts of vomiting per 24 h, with addition of abdominal pain, or fever.
  • 365
  • 10 Feb 2022
Topic Review
Acute Infective Endocarditis
Infective endocarditis (IE) is a potentially fatal disease with a mortality rate of over 20%, largely unmodified over recent decades. Mechanisms of IE pathogenesis are still incompletely understood but involve bacteria, host immune responses and the coagulation system.
  • 392
  • 30 Nov 2021
Topic Review
Adipocytokines Produced by Adipose Tissue
The alterations of adipocyte-derived signal mediators strongly influence the regulation of inflammation, resulting in chronic low-grade inflammation.
  • 899
  • 23 Jun 2021
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