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Topic Review
Hydrolyzable Tannins' (Castanea Sativa) Mechanism of Action
Hydrolyzable tannins (HTs) deriving from chestnuts have demonstrated, through numerous studies, the ability to exert multiple beneficial effects, including antioxidant and antimicrobial effects, on the lipid metabolism and cancer cells. The latter effect is very fascinating, since different polyphenols deriving from chestnuts were able to synergistically induce the inhibition of cancerous cells through multiple pathways. Moreover, the main mechanisms by which tannins induce antioxidant functions include: the reduction in oxidative stress, the ability to scavenge free radicals, and the modulation of specific enzymes, such as superoxide dismutase. 
  • 246
  • 03 Jan 2024
Topic Review
Human Givens
Human Givens is the name of a theory in psychotherapy formulated in the United Kingdom , first outlined by Joe Griffin and Ivan Tyrrell in the late 1990s. and amplified in the 2003 book Human Givens: A new approach to emotional health and clear thinking. The human givens organising ideas proffer a description of the nature of human beings, the 'givens' of human genetic heritage and what humans need in order to be happy and healthy. Human Givens therapy seeks to use a "client's strengths to enable them to get emotional needs met". It is advertised as "drawing from the best of person-centred counselling, motivational interviewing, cognitive behavioural therapy, psychoeducational approaches, interpersonal therapy, imaginal exposure and hypnotherapy". The Human Givens Institute has been accredited in the UK by the Professional Standards Authority for Health and Social Care (PSA).
  • 931
  • 09 Nov 2022
Topic Review
HSPs and Ovarian Cancer
Ovarian cancer is a serious cause of death in gynecological oncology. Delayed diagnosis and poor survival rates associated with late stages of the disease are major obstacles against treatment efforts. Heat shock proteins (HSPs) are stress responsive molecules known to be crucial in many cancer types including ovarian cancer. Clusterin (CLU), a unique chaperone protein with analogous oncogenic criteria to HSPs, has also been proven to confer resistance to anti-cancer drugs. Indeed, these chaperone molecules have been implicated in diagnosis, prognosis, metastasis and aggressiveness of various cancers. However, relative to other cancers, there is limited body of knowledge about the molecular roles of these chaperones in ovarian cancer. Here, we shed light on the diverse roles of HSPs as well as related chaperone proteins like CLU in the pathogenesis of ovarian cancer and elucidate their potential as effective drug targets.
  • 450
  • 31 Aug 2021
Topic Review
HRCT of Drug-Induced ILD
Interstitial Lung Diseases (ILDs) represent a heterogeneous group of pathologies, which may be related to different causes. A low percentage of these lung diseases may be secondary to the administration of drugs or substances. Several different high resolution computed tomography (HRCT) patterns related to pulmonary drug toxicity have been reported in literature, and the most frequent ILDs patterns reported include Nonspecific Interstitial Pneumonia (NSIP), Usual Interstitial Pneumonia (UIP), Hypersensitivity Pneumonitis (HP), Organizing Pneumonia (OP), Acute Respiratory Distress Syndrome (ARDS), and Diffuse Alveolar Damage (DAD). 
  • 934
  • 14 Jul 2021
Topic Review
Honokiol
Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is largely caused by a variety of gene mutations. There are continuous efforts being made to develop effective cancer treatments as resistance to current anticancer drugs has been on the rise. Natural products represent a promising source in the search for anticancer treatments as they possess unique chemical structures and combinations of compounds that may be effective against cancer with a minimal toxicity profile or few side effects compared to standard anticancer therapy. Extensive research on natural products has shown that bioactive natural compounds target multiple cellular processes and pathways involved in cancer progression.
  • 802
  • 18 Aug 2021
Topic Review
Hodgkin Lymphoma
Hodgkin lymphoma (HL) is a rare neoplasm of the lymphatic system representing one of the most common cancers in young adults. The disease is characterized by a low number of malignant cells (Hodgkin- and  Reed-Sternberg cells) deriving from B-lymphocytes and an extensive inflammatory microenvironment This unique histopathological picture and its pathogenesis are still only partially understood. 
  • 669
  • 08 Jul 2021
Topic Review
Histamine
Histamine [2-(4-imidazolyl)-ethylamine] is a biogenic amine that was first synthesized in the early 1900s. Histamine is a biogenic amine with numerous effects on many cell types, mediated by the activation of its four different histamine receptors (H1–H4Rs).
  • 457
  • 08 Nov 2022
Topic Review
High-Risk Pregnancy
A high-risk pregnancy is one where the mother or the fetus has an increased risk of adverse outcomes compared to uncomplicated pregnancies. No concrete guidelines currently exist for distinguishing “high-risk” pregnancies from “low-risk” pregnancies, however there are certain studied conditions that have been shown to put the mother or fetus at a higher risk of poor outcomes. These conditions can be classified into three main categories: health problems in the mother that occur before she becomes pregnant, health problems in the mother that occur during pregnancy, and certain health conditions with the fetus. In 2012, the CDC estimated that there were approximately 65,000 pregnancies deemed "high-risk" in the United States.
  • 271
  • 14 Nov 2022
Topic Review
Hereditary Angioedema (HAE)
Hereditary angioedema (HAE) is a rare disease caused by a genetic alteration of the SERPING1 gene and characterized by recurrent attacks of angioedema that involve the skin, and the mucosae of the gastrointestinal tract and upper airways, which significantly affect the quality of life of patients. 
  • 138
  • 23 Jan 2024
Topic Review
Herbal Biomedicines for Dermatological Disorders
Herbal extracts and isolated plant compounds play an increasing role in the treatment of skin disorders and wounds. Several new herbal drugs, medicinal products and cosmetic products for the treatment of various skin conditions have been developed in recent years. 
  • 688
  • 01 Jul 2021
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