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Topic Review
Pyrimidine Biosynthetic Enzyme CAD
CAD (Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and Dihydroorotase) is a multifunctional protein that participates in the initial three speed-limiting steps of pyrimidine nucleotide synthesis. Over the past two decades, extensive investigations have been conducted to unmask CAD as a central player for the synthesis of nucleic acids, active intermediates, and cell membranes. Meanwhile, the important role of CAD in various physiopathological processes has also been emphasized.
  • 904
  • 27 Oct 2021
Topic Review
The Similarity between Personality Traits and Basic Emotions
A great deal of evidence suggests that personality and emotions are linked via coping behaviors and that emotional features can be viewed as an emergent attribute for personality. Personality traits are the building blocks of personality, and psychologists have made many efforts to define and organize personality traits. They are often bundled together based on broad personality factors, such as the dimensions or the Big Five trait taxonomy. These personality traits are closely related to emotional characteristics and reflect emotional types and intensity in certain situations, as well as how individuals learn to cope with these emotions. Personality traits can in turn influence how people feel emotionally when things come up.
  • 668
  • 09 Sep 2022
Topic Review
Domestic Violence and Abuse
Domestic violence is considered to be all acts of physical, sexual, psychological or economic violence that occur within the family or domestic unit or between former or current spouses or partners, whether or not the perpetrator shares or has shared the same residence with the victim.
  • 662
  • 21 Jun 2021
Topic Review
Growth Hormone and IGF1 Actions in Kidney
Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1).
  • 647
  • 17 Dec 2021
Topic Review
Vascular Smooth Muscle Cells Biomechanics
Cardiovascular diseases are one of the leading causes of global death in developing countries. More than 80% of cardiovascular disease-associated mortality is attributable to atherosclerosis, a chronic inflammatory disease of the vessel wall. During the development of atherosclerosis and other cardiovascular diseases, vascular smooth muscle cells (SMCs) continuously shift from a contractile state towards other phenotypes that differ substantially from differentiated SMCs.
  • 607
  • 22 Sep 2021
Topic Review
The Role of the Cerebellum in Spatial Navigation
Although the function of the cerebellum has typically been associated with motor functions, several recent studies point to the cerebellum being involved in various cognitive functions, including spatial navigation. More specifically, clinical and neuroimaging evidence  suggests a functional and anatomical distinction between sensorimotor and cognitive cerebellum. The latter includes lobule VI, Crus I and II and lobule VIIB of the posterior lobe, which have been linked to different aspects of executive functions.
  • 588
  • 18 May 2022
Topic Review
Circulatory microRNAs in Major Depressive Disorder
Major depressive disorder (MDD) is the most prevalent, chronic, and complicated neuropsychiatric disorder of the current era, causing 800,000 people to commit suicides annually (WHO, 2020). In MDD, several miRNAs have been identified in disease progression by targeting various pathogenic proteins or associated pathways, and they are dysregulated by pathogenic protein expression.
  • 450
  • 24 Feb 2022
Topic Review
Target-Based Small Molecule Drug for Colorectal Cancer
Cancer does not develop from a single gene defect in a similar way to how it occurs in other diseases such as cystic fibrosis or muscular dystrophy. Instead, cancer becomes invasive in the event that there are multiple cancer gene mutations where the safeguarding mechanisms could not protect the normal and healthy mammalian cells from their lethal effects. As a result, it is better to think of cancer genes that have been altered as contributing to, rather than causing, cancer. The development of colorectal cancer involves a multiple step process incited by a distinctive genomic instability which encourages the cancerous cells to multiply, as well as increases the chances of cell survival.
  • 449
  • 05 Jul 2022
Topic Review
Caregiver Burden
Caregiver burden is the stress which is perceived by caregivers due to the home care situation. The subjective burden is considered to be one of the most important predictors of negative outcomes from the home care situation.
  • 426
  • 10 Oct 2022
Topic Review
Biomarkers of Post-COVID Depression
Post-COVID depression affects people who have had SARS-CoV-2 infection. A very important issue for the mental health of the general population is to look for the causes of this complication and its biomarkers. This will help in faster diagnosis and effective treatment of the affected patients. 
  • 413
  • 28 Jan 2022
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