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Topic Review
Long Non-Coding RNAs in Neurodegenerative Diseases
Long non-coding RNAs (lncRNAs) are novel genetic biomarkers that can be used as exclusionary tools specific to Neurodegenerative diseases (NDDs). These historical biomarkers have been there for years, so a change in the approach is necessary to better diagnose and treat these NDDs.
  • 123
  • 18 Mar 2024
Topic Review
Role of Dioxygen in Microbial Bio-Oxygenation
Dioxygen (O2, more commonly referred to as molecular oxygen) is the only element in the Earth’s environment that is paramagnetic in its ground-state. Dioxygen-dependent enzymes (principally mono- and dioxygenases) play in relevant aspects of bio-oxygenation. This is reflected by the multiple strategic roles that dioxygen -dependent microbial enzymes play both in generating valuable synthons for chemoenzymatic synthesis and in facilitating reactions that help to drive the global geochemical carbon cycle. 
  • 193
  • 18 Mar 2024
Topic Review
ATF4 Role during HIV-1 Replication
Activating transcription factor 4 (ATF4) is a transcription factor known to regulate genes associated with the sensing of cellular stress such as amino acid deprival, protein misfolding, growth arrest, and cell death. Despite its key role at the crossroads of immune and stress responses, the precise impact of ATF4 during viral infections remains unclear. Thus, ATF4 has a dual role in promoting cell survival or cell death, but also in limiting infection or participating in viral replication.
  • 106
  • 18 Mar 2024
Topic Review
Mechanisms behind the Guar Drought Tolerance
Guar is an unpretentious plant and grows on both sandy and well-drained clay soils. Guar is self-pollinating with a negligible level of cross-pollination. The plants considerably vary in height (from 50 cm to 1.5 m). The stem is sturdy, becoming woody by the plant maturation. The main root is thick and tapering in its distal parts, deeply penetrating into the soil. Due to this, guar can perfectly sustain short-term drought. 
  • 225
  • 15 Mar 2024
Topic Review
MicroRNAs in Depression
Depression is a major contributor to the overall global burden of disease. The discovery of biomarkers for diagnosis or prediction of treatment responses and as therapeutic agents is a current priority. Previous studies have demonstrated the importance of short RNA molecules in the etiology of depression. The most extensively researched of these are microRNAs, a major component of cellular gene regulation and function. MicroRNAs function in a temporal and tissue-specific manner to regulate and modify the post-transcriptional expression of target mRNAs. They can also be shuttled as cargo of extracellular vesicles between the brain and the blood, thus informing about relevant mechanisms in the CNS through the periphery. 
  • 83
  • 15 Mar 2024
Topic Review
Interferon-Stimulated Genes as Influenza Virus Host Restriction Factors
Influenza virus exploits host factors to promote each step of its lifecycle. In turn, the host deploys antiviral or restriction factors that inhibit or restrict the influenza virus lifecycle at each of those steps. Two broad categories of host restriction factors can exist in virus-infected cells: (1) encoded by the interferon-stimulated genes (ISGs) and (2) encoded by the constitutively expressed genes that are not stimulated by interferons (non-ISGs). There are hundreds of ISGs known, and many, e.g., Mx, IFITMs, and TRIMs, have been characterized to restrict influenza virus infection at different stages of its lifecycle, by (1) blocking viral entry or progeny release, (2) sequestering or degrading viral components and interfering with viral synthesis and assembly, or (3) bolstering host innate defenses. 
  • 87
  • 15 Mar 2024
Topic Review
Grandidier's Mongoose
Grandidier's mongoose (Galidictis grandidieri) (Figure 1) is a rare and elusive carnivore native to Madagascar. Named after the French naturalist Alfred Grandidier, this mongoose species is distinguished by its slender body, short legs, and long, bushy tail. Endemic to Madagascar's dry deciduous forests, Grandidier's mongoose is known for its solitary and nocturnal habits, making it a challenging species to study in its natural habitat.
  • 292
  • 15 Mar 2024
Topic Review
Harp Seal
The Harp Seal, also known by its scientific name Phoca groenlandica, is a marine mammal renowned for its striking appearance and unique life history. Recognized by the distinctive black harp-shaped markings on its coat, the Harp Seal inhabits the icy waters of the North Atlantic and Arctic Oceans. This species undergoes remarkable migrations and breeding events, with large aggregations congregating on ice floes each spring to give birth and nurse their pups.
  • 331
  • 15 Mar 2024
Topic Review
Gray Seal
The Gray Seal, scientifically known as Halichoerus grypus, is a marine mammal renowned for its distinctive appearance and widespread distribution across the North Atlantic Ocean. Characterized by its robust build, long whiskers, and mottled gray fur, the Gray Seal is a highly adaptable species found inhabiting coastal waters, rocky shores, and sandy beaches from Canada to Europe. As a top predator in marine ecosystems, the Gray Seal plays a crucial role in regulating prey populations and maintaining ecosystem balance.
  • 224
  • 15 Mar 2024
Topic Review
Kodkod
The Kodkod, scientifically known as Leopardus guigna, is a small wild cat species native to the temperate forests of South America. It is one of the smallest wild cats in the Americas, with adults typically weighing between 2 to 3 kilograms. Despite its diminutive size, the Kodkod is a skilled predator, preying on small mammals, birds, and insects, and plays a crucial role in maintaining ecosystem balance within its habitat.
  • 433
  • 15 Mar 2024
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