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Topic Review
Polyphenolic-Food and Longevity
Aging and, particularly, the onset of age-related diseases are associated with tissue dysfunction and macromolecular damage, some of which can be attributed to accumulation of oxidative damage. Recently, growing interest has emerged on the beneficial effects of plant-based diets for the prevention of chronic diseases including obesity, diabetes, and cardiovascular disease. Several studies collectively suggests that the intake of polyphenols and their major food sources may exert beneficial effects on improving insulin resistance and related diabetes risk factors, such as inflammation and oxidative stress. They are the most abundant antioxidants in the diet, and their intake has been associated with a reduced aging in humans. Polyphenolic intake has been shown to be effective at ameliorating several age-related phenotypes, including oxidative stress, inflammation, impaired proteostasis, and cellular senescence, both in vitro and in vivo.
  • 2.6K
  • 06 May 2022
Topic Review
Tissues to Implant Abutments
This entry is based on the fact that physical or biomechanical phenomena can cause biologic results. Implant-abutment connection structures determine the stability of soft tissue attachment to abutments. The bone responses to the strain that the stress is converted to, not the stress itself. Some implant-abutment materials and connection designs prevent the marginal bone loss by converting the stress to the strain stimulating bone apposition properly. These biomechanical interpretation of soft tissue seal and bone stimulation should be understood for the clinical long-term success of dental implants.
  • 2.6K
  • 27 Oct 2020
Topic Review
Hypertensive Nephropathy
Hypertension is one of the most common risk factors for developing chronic cardiovascular diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes damage and activation of mesangial cells (MCs), eliciting the production of large amounts of vasoactive and proinflammatory agents. Accordingly, the activation of AT1 receptors by the vasoactive molecule angiotensin II (AngII) contributes to the pathogenesis of renal damage, which is mediated mostly by the dysfunction of intracellular Ca2+ ([Ca2+]i) signaling. Similarly, inflammation entails complex processes, where [Ca2+]i also play crucial roles. Deregulation of this second messenger increases cell damage and promotes fibrosis, reduces renal blood flow, and impairs the glomerular filtration barrier. In vertebrates, [Ca2+]i signaling depends, in part, on the activity of two families of large-pore channels: hemichannels and pannexons. Interestingly, the opening of these channels depends on [Ca2+]i signaling. 
  • 2.6K
  • 23 Dec 2022
Topic Review
Dewi Sri
Dewi Sri or Shridevi (Javanese: ꦢꦺꦮꦶꦱꦿꦶ), Dewi Sri) (Sundanese: Nyai Pohaci Sanghyang Asri) is the Javanese, Sundanese, and Balinese Hindu Goddess of rice and fertility, still widely worshiped on the islands of Java, Bali and Lombok, Indonesia. The cult of the rice goddess has its origin in the prehistoric domestication, development and propagation of rice cultivation in Asia, possibly brought by Austroasiatic or Austronesian population that finally migrated and settled in the archipelago. Similar but slightly different rice spirits mythologies are widespread among Indonesian ethnicities and also neighboring countries. The mythology of Dewi Sri is native to Java and Sunda and Hinduism in the archipelago since early as the first century. She was equated with the Hindu goddess Shri Lakshmi, and often regarded as an incarnation or one of her manifestations. The goddess is also associated with wealth and prosperity.
  • 2.6K
  • 11 Oct 2022
Topic Review
Seed Priming
Seed nano-priming is an efficient process that can change seed metabolism and signaling pathways, affecting not only germination and seedling establishment but also the entire plant lifecycle.
  • 2.5K
  • 13 Jan 2022
Topic Review
Sinhapura
Sinhapura (Sanskrit, "Lion City"; IAST: Siṃhapura) was the capital of the legendary Indian king Sinhabahu. It has been mentioned in the Buddhist legends about Prince Vijaya. The name is also transliterated as Sihapura or Singhapura. The location of Sinhapura is disputed with some scholars claiming the city was located in eastern India and others claiming it was located in present-day Malaysia or Thailand. The city is linked to the origin of the Sinhalese people and Sinhalese Buddhist mythology.
  • 2.5K
  • 27 Oct 2022
Topic Review
Potato Virus Y
Potato virus Y origin, emergence and evolution.
  • 2.5K
  • 21 Dec 2020
Topic Review
Milk Fat Globule Membrane (MFGM)
Milk fat globule membrane (MFGM) is an important component of milk lipids that showed several biological properties (such as anticarcinogenic, antimicrobial, anti-inflammatory, and anticholesterolemic activities). In this review we analyse the latest results obtained from comparative proteomic studies regarding the variations and the similarities of MFGM proteome across species and lactation stages. Infant formula supplementation with MFGM represents an interesting opportunity to implement the bioactive properties exerted by MFGM, in order to narrow the gap between human breast milk and infant formula. 
  • 2.5K
  • 27 Sep 2020
Topic Review
Convergent Evolution
Convergent evolution is the independent evolution of similar features in species of different periods or epochs in time. Convergent evolution creates analogous structures that have similar form or function but were not present in the last common ancestor of those groups. The cladistic term for the same phenomenon is homoplasy. The recurrent evolution of flight is a classic example, as flying insects, birds, pterosaurs, and bats have independently evolved the useful capacity of flight. Functionally similar features that have arisen through convergent evolution are analogous, whereas homologous structures or traits have a common origin but can have dissimilar functions. Bird, bat, and pterosaur wings are analogous structures, but their forelimbs are homologous, sharing an ancestral state despite serving different functions. The opposite of convergence is divergent evolution, where related species evolve different traits. Convergent evolution is similar to parallel evolution, which occurs when two independent species evolve in the same direction and thus independently acquire similar characteristics; for instance, gliding frogs have evolved in parallel from multiple types of tree frog. Many instances of convergent evolution are known in plants, including the repeated development of C4 photosynthesis, seed dispersal by fleshy fruits adapted to be eaten by animals, and carnivory.
  • 2.5K
  • 24 Oct 2022
Topic Review
Domestic Turkey
The domestic turkey (Meleagris gallopavo domesticus) is a large fowl, one of the two species in the genus Meleagris and the same species as the wild turkey. Although turkey domestication was thought to have occurred in central Mesoamerica at least 2,000 years ago, recent research suggests a possible second domestication event in the southwestern United States between 200 BC and AD 500. However, all of the main domestic turkey varieties today descend from the turkey raised in central Mexico that was subsequently imported into Europe by the Spanish in the 16th century. The domestic turkey is a popular form of poultry, and it is raised throughout temperate parts of the world, partially because industrialized farming has made it very cheap for the amount of meat it produces. Female domestic turkeys are referred to as hens, and the chicks may be called poults or turkeylings. In the United States, the males are referred to as toms, while in the United Kingdom and Ireland, males are stags. The great majority of domestic turkeys are bred to have white feathers because their pin feathers are less visible when the carcass is dressed, although brown or bronze-feathered varieties are also raised. The fleshy protuberance atop the beak is the snood, and the one attached to the underside of the beak is known as a wattle. The English-language name for this species results from an early misidentification of the bird with an unrelated species which was imported to Europe through the country of Turkey. The Latin species name gallopāvō means "chicken peacock".
  • 2.5K
  • 18 Nov 2022
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