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Topic Review
Host Immune Responses to Clostridioides difficile Infection
Clostridioides difficile infection (CDI) is a leading nosocomial infection, posing a substantial public health challenge within the United States and globally. C. difficile releases toxins, which damage large intestinal epithelium, leading to toxic megacolon, sepsis, and even death.
  • 102
  • 07 Feb 2024
Topic Review
CK2 in Musculoskeletal Disorders
Protein kinase CK2 (CK2) influences one-fifth of the cellular phosphoproteome. It regulates almost all cellular pathways and is thus a critical switch between biological processes within a cell. Inhibition of CK2 reverses oncogene addiction of tumor and alters tumor microenvironment.
  • 110
  • 07 Feb 2024
Topic Review
Alexander's Kusimanse
Alexander's Kusimanse (Crossarchus alexandri) is a captivating and lesser-known member of the mongoose family, native to the tropical forests of West Africa. Recognized for its distinctive appearance and intriguing social behaviors, this small carnivore plays a significant role in the ecosystems it inhabits.
  • 469
  • 07 Feb 2024
Topic Review
Exosomes-Mediated Signaling Pathway for Organ Ischemia-Reperfusion Injury Treatment
Ischemia reperfusion (I/R) is a common pathological process which occurs mostly in organs like the heart, brain, kidney, and lung. The injury caused by I/R gradually becomes one of the main causes of fatal diseases, which is an urgent clinical problem to be solved. Although great progress has been made in therapeutic methods, including surgical, drug, gene therapy, and transplant therapy for I/R injury, the development of effective methods to cure the injury remains a worldwide challenge. 
  • 211
  • 07 Feb 2024
Topic Review
Parkinson’s Disease-Associated Gene, Parkin
Parkin, the gene responsible for hereditary Parkinson’s disease (PD) called “Autosomal Recessive Juvenile Parkinsonism (AR-JP)” was discovered a quarter of a century ago.
  • 134
  • 06 Feb 2024
Topic Review
Oxidative Stress in Malaria
Malaria is a significant public health problem in more than 100 countries and causes an estimated 200 million new infections every year.
  • 218
  • 06 Feb 2024
Topic Review
Food Waste and Sustainability Impact
Food losses in the agri-food sector have been estimated as representing between 30 and 80% of overall yield. The agro-food sector has a responsibility to work towards achieving FAO sustainable goals and global initiatives on responding to many issues, including climate pressures from changes we are experiencing globally. 
  • 375
  • 06 Feb 2024
Topic Review
Greenhouse Gas Emission Reduction Strategies in Dairy Farming
In the pursuit of reducing greenhouse gas (GHG) emissions in dairy farming, a combination of innovative practices, technological advancements, and supportive policy initiatives plays a pivotal role. Addressing the emissions from this sector is crucial for mitigating climate change impacts given the significant contribution of dairy farming to global GHG emissions, particularly methane (CH4) and nitrous oxide (N2O).
  • 135
  • 06 Feb 2024
Topic Review
Interplay of BDNF and Glucocorticoids in Alzheimer’s Disease
Both the brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) play multiple roles in various aspects of neurons, including cell survival and synaptic function. BDNF and its receptor TrkB are extensively expressed in neurons of the central nervous system (CNS), and the contribution of the BDNF/TrkB system to neuronal function is evident; thus, its downregulation has been considered to be involved in the pathogenesis of Alzheimer’s disease (AD). GCs, stress-related molecules, and glucocorticoid receptors (GRs) are also considered to be associated with AD in addition to mental disorders such as depression. Importantly, a growing body of evidence suggests a close relationship between BDNF/TrkB-mediated signaling and the GCs/GR system in the CNS.
  • 166
  • 06 Feb 2024
Topic Review
Plant Growth Regulation in Cell and Tissue Culture
Precise knowledge of all aspects controlling plant tissue culture and in vitro plant regeneration is crucial for plant biotechnologists and their correlated industry, as there is increasing demand for such scientific knowledge, which results in more productive and resilient in vitro plant propagation and acclimatization in the field. Surprisingly, but so far, researchers/industry-based protocols on the 60-year-old concepts ignore new plant physiology achievements. Namely, high nitrogen and halogens used in the culture medium and exogenous auxin/cytokinin ratio regulate plant morphogenesis.
  • 437
  • 05 Feb 2024
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